A5077469902- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Occupational and environmental lung diseases
- HIV/AIDS Research and Interventions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Osteoarthritis Treatment and Mechanisms
- Genetic Associations and Epidemiology
- HIV, Drug Use, Sexual Risk
- Occupational exposure and asthma
- Genetic factors in colorectal cancer
- Obesity, Physical Activity, Diet
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Air Quality and Health Impacts
- Circular RNAs in diseases
- RNA Research and Splicing
- Adolescent Sexual and Reproductive Health
- Ubiquitin and proteasome pathways
- Inflammatory mediators and NSAID effects
- HIV Research and Treatment
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Hepatitis C virus research
Nantong University
2016-2025
University of California, Los Angeles
2018-2019
X-Fab (Germany)
2018
Shanghai Skin Disease Hospital
2017
Melbourne Sexual Health Centre
2017
Alfred Health
2017
Monash University
2017
Nanjing Medical University
2011-2016
Jiangsu Cancer Hospital
2012
Jiangsu Province Hospital
2012
Immune functions decline with aging, leading to increased susceptibility various diseases including tumors. Exploring aging-related molecular targets in elderly patients cancer is thus highly sought after. Here we find that an ER transmembrane enzyme, sterol O-acyltransferase 2 (SOAT2), overexpressed regulatory T (Treg) cells from lung squamous cell carcinoma (LSCC), while radiomics analysis of LSCC associates SOAT2 expression reduced immune infiltration and poor prognosis. Mechanically, ex...
Genome-wide association studies (GWAS) have recently identified KIF1B as susceptibility locus for hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC). To further identify novel loci associated with HBV–related HCC and replicate the previously reported association, we performed a large three-stage GWAS in Han Chinese population. 523,663 autosomal SNPs 1,538 HBV–positive patients 1,465 chronic HBV carriers were genotyped discovery stage. Top candidate initial validation samples of...
Recent genome-wide association studies showed that four single-nucleotide polymorphisms (SNPs) in human leukocyte antigen (HLA)-DP (rs3077 and rs9277535) HLA-DQ (rs2856718 rs7453920) were associated with chronic hepatitis B virus (HBV) infection Japanese populations. More than 75% of hepatocellular carcinoma (HCC) patients are attributable to persistent (HBV), especially China. We genotyped these SNPs 1,300 HBV-positive HCC patients, 1,344 HBV carriers, persons natural clearance from...
Food safety and hygiene are currently a global health apprehension especially in unindustrialized countries as result of increasing food-borne diseases (FBDs) accompanying deaths. This study aimed at assessing knowledge, attitude, practices (KAP) food among street-cooked handlers (SCFHs) North Dayi District, Ghana.This was descriptive cross-sectional conducted on 407 SCFHs Ghana. The World Health Organization's Five Keys to Safer for pretested structured questionnaire were adapted data...
Syphilis control programs have been scaled up due to the substantial burden in China. We analyzed syphilis incidence according demographic, spatiotemporal, and economic factors. The increasing latent diagnoses declining congenital suggest effectiveness of scale-up screening. However, primary secondary cases persist, especially inland provinces.
Existing studies reported that some circular RNAs (circRNAs) play vital roles in the development of pulmonary fibrosis. However, few explored biomarker potential circRNAs for fibrosis based on population data. Therefore, we aimed to identify peripheral blood as biomarkers diagnosing silicosis and idiopathic (IPF). In brief, an RNA-seq screening 4 cases controls was initially performed. Differentially expressed were combined with human serum circRNA dataset overlapping serum-detectable...
Genetic variation may influence chemotherapy response and overall survival in cancer patients.We conducted a genome-wide scan 535 advanced-stage non-small cell lung (NSCLC) patients from two independent cohorts (307 Nanjing 228 Beijing). A replication was carried out on an cohort of 340 Southeastern China followed by second validation 409 the Massachusetts General Hospital (Boston, MA).Consistent associations with NSCLC were identified for five single-nucleotide polymorphisms (SNP) Chinese...
The goal of this study was to assess risk factors associated with HIV/AIDS progression. Between May 2007 and December 2014, 114 subjects were enrolled in Wuxi City examined every 6 months. pol gene sequence amplified ascertain the HIV-1 subtype. A Cox proportional hazards regression model used estimate median follow-up time for all 26.70 months (IQR: 18.50-41.47), while progression 38 progressed 24.80 14.13-34.38). Overall, CRF01_AE subtype correlated a significant accelerated compared...
Diabetic foot ulcers (DFUs) are a common but serious complication of diabetes mellitus (DM). The factors distressing the worth diabetic care (DFC) knowledge and practice. Foot main cause amputation death in people suffering from DM. This study assessed practice DFC prevalence DFUs its associated among patients selected hospitals Volta Region, Ghana. A multihospital-based cross-sectional was conducted 473 with DM who were recruited using systematic sampling method. Data collected validated,...
Identifying the common functional single-nucleotide polymorphisms (SNPs) that can both affect susceptibility to idiopathic pulmonary fibrosis (IPF) and silicosis. We first integrated genome-wide association studies (GWASs) of IPF silicosis obtain shared SNPs. Following this, expression quantitative trait locus (eQTL)-SNPs were identified by GTEx database. This was followed validation correlation between these eQTL-SNPs through an additional case-control study including 194 cases 235 healthy...