Shuangshuang Wu
A5070889542- Acute Myeloid Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Histone Deacetylase Inhibitors Research
- Chronic Myeloid Leukemia Treatments
- Plant Gene Expression Analysis
- Neurological Disease Mechanisms and Treatments
- RNA Interference and Gene Delivery
- Protein Degradation and Inhibitors
- Biochemical and Molecular Research
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Photodynamic Therapy Research Studies
- DNA and Nucleic Acid Chemistry
- Drug Transport and Resistance Mechanisms
- Nuclear Structure and Function
- Phytochemicals and Antioxidant Activities
- Potato Plant Research
- Metal complexes synthesis and properties
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
Anhui Normal University
2025
Jiangsu Province Hospital
2025
First Hospital of Jilin University
2022-2025
Jilin University
2022-2025
Nanjing Medical University
2024-2025
Immune functions decline with aging, leading to increased susceptibility various diseases including tumors. Exploring aging-related molecular targets in elderly patients cancer is thus highly sought after. Here we find that an ER transmembrane enzyme, sterol O-acyltransferase 2 (SOAT2), overexpressed regulatory T (Treg) cells from lung squamous cell carcinoma (LSCC), while radiomics analysis of LSCC associates SOAT2 expression reduced immune infiltration and poor prognosis. Mechanically, ex...
Abstract Eradication of acute myeloid leukemia (AML) is therapeutically challenging; many patients succumb to AML despite initially responding conventional treatments. Here, we showed that the imipridone ONC213 elicits potent antileukemia activity in a subset cell lines and primary patient samples, particularly stem cells, while producing negligible toxicity normal hematopoietic cells. suppressed mitochondrial respiration elevated α-ketoglutarate by suppressing dehydrogenase (αKGDH)...
A chemicobiology toolbox for type I and II photodynamic therapy.
The acidic taste of Mei fruit (Prunus mume) is a major contributor to its quality, but formation mechanism remains unclear. Here, we unraveled the networks organic acid and flavonoid metabolism in two fruit. results showed that differentially expressed genes were mainly concentrated processes carbohydrate derivative binding, carboxylic acid, metabolism. While accumulated metabolites associated with flavone flavonol biosynthesis amino carbon Moreover, identified key metabolites, such as...
Background Hypoxia and leptin receptors (also called obesity receptors, OB-R) are evident markers of tumor progression have been demonstrated to be essential oncogenes in a variety cancers. However, the specific role OB-R lung cancer, especially non-small cell cancer (NSCLC) its correlation with HIF1α remains unclear. Present study aims explore potential functions mechanisms NSCLC. Methods The RNA levels NSCLC cells were detected by quantitative real-time PCR (qRT-PCR) western blotting....
Abstract Acute myeloid leukaemia (AML) is a highly heterogeneous haematologic malignancy with poor prognosis. We previously showed synergistic antileukaemic interaction between exportin 1 (XPO1) inhibitor KPT‐330 (Selinexor) and Bcl‐2 venetoclax (ABT‐199) in preclinical models of AML, which was partially meditated by Mcl‐1, although the full mechanism action remains unknown. In this study, using real‐time RT‐PCR Western blot analysis, we show that inhibition XPO1 via or KPT‐8602 (Eltanexor)...
The 5-year overall survival rate of acute myeloid leukemia (AML) is less than 30%. Improving clinical outcomes still a challenge for AML treatment. Simultaneous use chemotherapeutic drugs and targeting apoptosis pathways has become first-line treatment AML. Myeloid cell 1 (MCL-1) candidate target In this study, we demonstrated that inhibition the anti-apoptotic protein MCL-1 by AZD5991 synergistically increased agent cytarabine (Ara-C)-induced in lines primary patient samples. Apoptosis...
FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (FLT3-ITD) mutations occur in about 25% of all acute myeloid leukemia (AML) patients and confer a poor prognosis. FLT3 inhibitors have been developed to treat with FLT3-mutated AML shown promise, though the acquisition resistance occurs, highlighting need for combination therapies prolong response inhibitors. In this study, we investigated selective Mcl-1 inhibitor AZD5991 gilteritinib MRX-2843. The combinations synergistically...
<p>THP-1 metabolomics data</p>
<p>Supplementary Figure S5</p>
<p>Supplementary Figure S7</p>
<p>THP-1 metabolomics data</p>
<p>Patient characteristics for AML cell lines</p>
<p>Patient characteristics of primary AML patient samples</p>
<p>Supplementary Figure S7</p>
<p>Supplementary Figure S1</p>
<div>Abstract<p>Eradication of acute myeloid leukemia (AML) is therapeutically challenging; many patients succumb to AML despite initially responding conventional treatments. Here, we showed that the imipridone ONC213 elicits potent antileukemia activity in a subset cell lines and primary patient samples, particularly stem cells, while producing negligible toxicity normal hematopoietic cells. suppressed mitochondrial respiration elevated α-ketoglutarate by suppressing...
<p>Supplementary Figure S9</p>
<p>Supplementary Figure S4</p>
<p>Supplementary Methods</p>
<p>Supplementary Methods</p>