A5102897099- International Business and FDI
- Neurological Disease Mechanisms and Treatments
- RNA modifications and cancer
- Plant Gene Expression Analysis
- Nanoparticle-Based Drug Delivery
- Scientific Computing and Data Management
- Distributed and Parallel Computing Systems
- Computational Drug Discovery Methods
- RNA Research and Splicing
- FinTech, Crowdfunding, Digital Finance
- Web Data Mining and Analysis
- Glycosylation and Glycoproteins Research
- Protease and Inhibitor Mechanisms
- Ferroptosis and cancer prognosis
- Cell Adhesion Molecules Research
- Cancer therapeutics and mechanisms
- Organizational and Employee Performance
- Synthesis and bioactivity of alkaloids
- Law, Economics, and Judicial Systems
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Phytochemicals and Antioxidant Activities
- Potato Plant Research
- Genomics and Chromatin Dynamics
- Immune Cell Function and Interaction
Anhui Normal University
2025
Zhongnan Hospital of Wuhan University
2022-2024
Wuhan University
2022-2024
Binzhou University
2023
Binzhou Medical University
2023
Capital Medical University
2021
Institute of Industrial Economics
2016
Jinan University
2016
Abstract Background Splicing factors are vital for the regulation of RNA splicing, but some have also been implicated in regulating transcription. The underlying molecular mechanisms their involvement transcriptional processes remain poorly understood. Results Here, we describe a direct role splicing factor RBM22 coordinating multiple steps Polymerase II (RNAPII) transcription human cells. protein widely occupies RNAPII-transcribed gene locus nucleus. Loss promotes RNAPII pause release,...
The acidic taste of Mei fruit (Prunus mume) is a major contributor to its quality, but formation mechanism remains unclear. Here, we unraveled the networks organic acid and flavonoid metabolism in two fruit. results showed that differentially expressed genes were mainly concentrated processes carbohydrate derivative binding, carboxylic acid, metabolism. While accumulated metabolites associated with flavone flavonol biosynthesis amino carbon Moreover, identified key metabolites, such as...
Purpose: To assess whether the newly designed small-molecule oral P-selectin inhibitor 3 S -1,2,3,4-tetrahydro-β-carboline-3-methyl aspartyl ester (THCMA) as a nanomedicine enhances antithrombosis, anti-inflammation, and antitumor activity more than clinical trial drug PSI-697. Methods: THCMA was an amphiphile containing pharmacophores of Its nanofeatures were explored with TEM, SEM, Tyndall effect, ζ-potential, FT-ICR-MS, NOESY 2D 1 H NMR. The inhibitory effect demonstrated molecular...
With the great development of China e-commerce industry, more and business transaction is moved from offline to online. Generated by a plenty series transactions online, multi-dimen-sional user data are used promote evolution Internet finance mode. In era “internet+”, all industries going through changes. The process supply chain also accelerates. Based on different characteristics participants, source paths, this paper gives an overall classification under background internet, which...
Abstract Background Cosmc (C1GalT1C1) mutation could cause aberrant O -glycosylation and result in expression of Tn antigen on the surface tumor cells (Tn + cells), which is associated with metastasis prognosis cancer progression. Mesenchymal stem (MSCs) participate immunoregulation, tissue damage repair, inhibition be seen as an ideal candidate for therapy due to their inherent capacity migrate sites. However, therapeutic effectiveness different tumors inconsistent still controversial. Of...
Given the prominent role of China as a manufacturing supply base, how to curtail local supplier opportunism becomes central concern for both domestic and foreign buyers. Drawing on institutional view, this study examines policy uncertainty ownership structures moderate roles explicit contracts trust in restricting China. Based analysis 293 buyer-supplier dyadic relationships China, finds that are effective safeguarding against when is high, whereas reduces low. Further, buyers, use more...
Background: Cytotoxic CD8+ T-cell exhaustion is the major barrier for immunotherapy in tumors. Recent studies have reported that basic leucine zipper activating transcription factor–like factor (BATF) responsible countering cytotoxic exhaustion. Nevertheless, expression and roles of BATF tumors been poorly explored. Methods: In present study, we conducted a multi-omics analysis, including gene expression, methylation status, DNA alterations, pharmacogenomics, survival status based on data...
Aim: SARS-CoV-2 caused more than 3.8 million deaths according to the WHO. In this urgent circumstance, we aimed at screening out potential inhibitors targeting main protease of SARS-CoV-2. Materials & methods: An in-house carboline and quinoline database including carboline, their derivatives was established. A virtual in database, 50 ns molecular dynamics simulations mechanics Poisson−Boltzmann surface area calculations were carried out. Results: The top 12 molecules screened preliminarily....
Drawing on institutional theory, this study examines how regulatory uncertainty and relationship structure moderate the role of contracts trust in restricting local supplier opportunism China. The results reveal that are more effective deterring when is high. In addition, help curtail domestic, compared with international, buyer-supplier relationships, whereas international relationships than domestic ones.
Despite the long recognition of dyadic nature interfirm trust, prior studies have not examined how trust asymmetry affects relationship outcomes. This study examines in buyer-supplier exchanges from a perspective, predicting that when buyer is greater than supplier leads to decrease performance over time. However, suppliers more buyers, prediction results an increase performance. The further incorporates institutional view examine moderating roles legal support and regulatory uncertainty. An...