A5100653346- RNA modifications and cancer
- RNA Research and Splicing
- Heat shock proteins research
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Endoplasmic Reticulum Stress and Disease
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Hormonal Regulation and Hypertension
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Geology and Paleoclimatology Research
- Geomagnetism and Paleomagnetism Studies
- Geological formations and processes
- Effects of Environmental Stressors on Livestock
- Parvovirus B19 Infection Studies
- Genomics and Chromatin Dynamics
- Advanced Thermodynamic Systems and Engines
- Autoimmune and Inflammatory Disorders
- interferon and immune responses
- Autophagy in Disease and Therapy
- Dermatological and COVID-19 studies
- Molecular Biology Techniques and Applications
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Qiqihar Medical University
2024
Qingdao University
2021-2023
Yuhuangding Hospital
2023
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2023
Affiliated Hospital of Qingdao University
2021
Yidu Central Hospital of Weifang
2021
Beijing Union University
2015
Shanghai Institutes for Biological Sciences
2015
Mitochondrial dysfunction is one of the hallmarks cardiovascular aging. The leakage mitochondrial DNA (mtDNA) increased in senescent cells, which are resistant to programmed cell death such as apoptosis. Due its similarity prokaryotic DNA, mtDNA could be recognized by cellular sensors and trigger innate immune responses, resulting chronic inflammatory conditions during mechanisms include cGAS-STING signaling, TLR-9 inflammasomes activation. quality controls mitophagy prevent mitochondria...
Abstract Background Splicing factors are vital for the regulation of RNA splicing, but some have also been implicated in regulating transcription. The underlying molecular mechanisms their involvement transcriptional processes remain poorly understood. Results Here, we describe a direct role splicing factor RBM22 coordinating multiple steps Polymerase II (RNAPII) transcription human cells. protein widely occupies RNAPII-transcribed gene locus nucleus. Loss promotes RNAPII pause release,...
Dysregulation of ribosome biogenesis causes human diseases, such as Diamond-Blackfan anemia, del (5q-) syndrome and bone marrow failure. However, the mechanisms blood disorders in these diseases remain elusive. Through genetic mapping, molecular cloning mechanism characterization zebrafish mutant cas002, we reveal a novel connection between ribosomal dysfunction excessive autophagy regulation hematopoietic stem/progenitor cells (HSPCs). cas002 carries recessive lethal mutation kri1l gene...
Objective To explore on the impact of integrated HPV type 18 carcinogenesis esophageal squamous cancer cell line EC9706. Methods A E7 gene silencing sequence was induced into pSUPER.retro.neo+ gfp vector to down regulate viral mRNA in EC9706 lines. Real time PCR and Western Blot were employed detect related genes both protein level respectively these The viability also detected by proliferate property. Results The E6 regulated stable lines obtained. results showed that there a...
目的： 探讨EB病毒阳性皮肤黏膜溃疡（EBVMCU）的临床及病理学特征。 方法： 回顾性分析2017至2021年烟台毓璜顶医院确诊的3例EBVMCU，采用免疫组织化学、原位杂交染色和分子重排技术检测，并复习相关文献。 结果： 3例患者中男性1例，女性2例，年龄分别为65、75和69岁。3例均为年龄相关性EBVMCU。病变局限于口腔黏膜2例、胃1例。1例有局部淋巴结肿大，3例均无肝、脾、骨髓受累，经保守治疗或化学药物治疗，预后均良好。3例EBVMCU患者在形态学上表现混杂的炎性细胞背景中见中至大的异型细胞浸润，部分形态似R-S细胞；异型细胞表达CD20、CD30、MUM1，Ki-67阳性指数高。3例病例原位杂交EB病毒编码的RNA（EBER）均阳性，免疫球蛋白分子重排结果均阴性。 结论： EBVMCU少见，发生在高龄、医源性免疫抑制和自身免疫缺陷人群，口腔黏膜是好发部位。3例病例未出现免疫球蛋白克隆性分子重排。.
Climate change and human activity can both exert a role in the river discharge sediment load deltas when sea level remains relatively stable. The Pearl River Delta constitutes metropolitan region of Guangdong–Hong Kong–Macau Greater Bay Area, its evolution past future impacts sustainable development this region. In manuscript, core situated northern South China Sea, adjacent to Qiao Island Zhuhai city Delta, was selected investigate hydrodynamic variation influenced by tropical processes...
Abstract Background : Recently, an increasing number of studies have revealed that N6-methyladenosine (m6A) functions as a significant post-transcriptional modification which plays critical role in the occurrence and progression enriched tumors by regulating coding non-coding RNA biogenesis. However, roles m6A hepatocellular carcinoma (HCC) remain largely unknown. Results In this study, expression levels, genetic variations, prognostic values gene–gene interaction network m6A-related genes...
Abstract Background: Hepatocellular carcinoma (HCC) is notorious for its poor prognosis. Increasing evidence has demonstrated that N6-methyladenosine (m6A) related genes plays key roles in initiation and progression of several types human cancer. However, the specific role mechanism m6A RNA modification HCC remains not fully determined. Previous studies identified m6A-related genes, especially ZC3H13, could be a high candidate as novel biomarker therapeutic target hepatocellular carcinoma....