A5108055601- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- RNA Research and Splicing
- Circular RNAs in diseases
- Biosensors and Analytical Detection
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Retinoids in leukemia and cellular processes
- Dermatology and Skin Diseases
- Advanced Biosensing Techniques and Applications
- Psoriasis: Treatment and Pathogenesis
- Gold and Silver Nanoparticles Synthesis and Applications
- Liver Disease Diagnosis and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Phytochemicals and Antioxidant Activities
- Molecular Sensors and Ion Detection
- Synthesis and biological activity
- Electrical and Thermal Properties of Materials
- Advanced MEMS and NEMS Technologies
- 3D IC and TSV technologies
- Ginseng Biological Effects and Applications
Ningxia Medical University
2019-2024
Ningxia Medical University General Hospital
2019-2024
ZheJiang Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
China West Normal University
2023
Macau University of Science and Technology
2022
State Key Laboratory of Bioreactor Engineering
2018-2021
East China University of Science and Technology
2018-2021
Abstract The hostile hypoxic microenvironment takes primary responsibility for the rapid expansion of breast cancer tumors. However, underlying mechanism is not fully understood. Here, using RNA sequencing (RNA-seq) analysis, we identified a hypoxia-induced long noncoding (lncRNA) KB-1980E6.3, which aberrantly upregulated in clinical tissues and closely correlated with poor prognosis patients. enhanced lncRNA KB-1980E6.3 facilitates stem cells (BCSCs) self-renewal tumorigenesis under both...
Exosomes, a class of small extracellular vesicles, play important roles in various physiological and pathological processes by serving as vehicles for transferring delivering membrane cytosolic molecules between cells. Since exosomes widely exist body fluids carry molecular information on their originating cells, they are being regarded potential noninvasive biomarkers. Nevertheless, the development convenient quantitative exosome analysis methods is still technically challenging. Here, we...
Exosomes, as important signal transmitters, play a key role in intercellular communication, especially cancer metastasis.
Background: Non-alcoholic fatty liver disease (NAFLD) is a common metabolic worldwide with chronic low-grade inflammation and alteration of gut microbiota. Inulin (INU) has been confirmed to exhibit benefit for diseases. The aim this study was clarify the effects mechanism INU on NAFLD via gut-liver axis. Methods: C57BL/6 mice were randomly divided into four groups: normal diet group (ND); high-fat (HFD); ND (ND-INU); HFD (HFD-INU). After 14 weeks feeding, sacrificed associated indications...
tRNA derivatives have been identified as a new kind of potential biomarker for cancer. Previous studies that there were 30 differentially expressed tRNAs in breast cancer tissue with the high-throughput sequencing technique. This study aimed to investigate possible biological function and mechanism cells. One such tRF, 5’-tRF fragment tRF-17-79MP9PP (tRF-17) was screened this study, which is processed from mature tRNA-Val-AAC tRNA-Val-CAC. tRF-17 significantly low expression tissues serum....
The increase of the Fusobacterium nucleatum level has been previously identified in various cancers including gastric cancer (GC), but how F. exerts its carcinogenic role GC remains unclear. Several studies revealed that contributes to progression via secretion extracellular vehicles (EVs). Hence, it's designed reveal influence nucleatum-derived EVs (Fn-EVs) progression. tumor and adjacent tissues were collected from 30 patients, abundance was found be highly expressed samples....
Abstract Background Splicing factors are vital for the regulation of RNA splicing, but some have also been implicated in regulating transcription. The underlying molecular mechanisms their involvement transcriptional processes remain poorly understood. Results Here, we describe a direct role splicing factor RBM22 coordinating multiple steps Polymerase II (RNAPII) transcription human cells. protein widely occupies RNAPII-transcribed gene locus nucleus. Loss promotes RNAPII pause release,...
Background/Aims: A recent study demonstrates that pro-inflammatory cytokines (PICs, i.e., IL-1β, IL-6 and TNF-α) in specific brain regions of rats play a role regulating kainic acid (KA)-induced status epilepticus (SE) via GABAergic mechanism. The purposes this report were to examine contributions hypoxia inducible factor subtype 1α (HIF-1α) expression PICs these epileptic rats. Particularly, we investigated the parietal cortex, hippocampus amygdala. In addition, further examined Caspase-3...
Abstract Gastric cancer continues to be a common in the world with high incidence and mortality. Accumulating evidence has implicated long noncoding RNAs (lncRNAs) gastric progression. Here, this study identified potential role of novel lncRNA, LINC00629 elucidate underlying mechanism. Initially, microarray‐based gene expression profiling was employed identify differentially expressed genes. Next, LINC00629, microRNA‐196b‐5p (miR‐196b‐5p) aquaporin 4 (AQP4) clinical tissues determined cell...
MicroRNAs (miRNAs) play a vital role in various biological processes and act as important biomarkers for clinical cancer diagnosis, prognosis, therapy.
Abstract The Warburg effect, one of the metabolic hallmarks cancer, is responsible for rapid energy production through a high rate aerobic glycolysis. Ginsenoside 20(S)‐Rg3 antagonizes effect in ovarian cancer cells by upregulating some microRNAs, including miR‐519a‐5p, that target key enzymes involved How 20(S)‐Rg3‐upregulated miR‐519a‐5p influences remains poorly defined, however. Here we report while overexpression inhibited inhibition negated suppressive action against as evidenced...
Schematic description of the proposed DNA-engineered exosome (DNA-Exo) for dual cancer biomarker imaging.
Objective Aging acts as a dominating risk factor for human cancers. Herein, we systematically dissected the features of transcriptional aging-relevant genes in gastric cancer from multiple perspectives. Methods Based on transcriptome profiling prognostic genes, patients with The Cancer Genome Atlas (TCGA) stomach adenocarcinoma (TCGA-STAD) cohort were clustered consensus clustering algorithm. Mutational landscape and chemotherapeutic responses analyzed immunological (immunomodulators, immune...
Hypoxia is a major hallmark of solid tumors and associated with malignant phenotypes. Exosomal miRNAs derived from hypoxia tumor cells are implicated in the modulation cancer progression, whereas, mechanisms underlying association between exosomal miR-25-3p during breast progression remain to be further clarified. The present study aimed investigate role regulating progression. Herein, we found that expression was increased tumor-derived exosomes HIF-1α-dependent manner. markedly stimulated...
Abstract Cellular proliferation, differentiation, and morphogenesis are shaped by multiple signaling cascades; their concurrent dysregulation plays an integral role in cancer progression is a common feature of many malignancies. Three such cascades that contribute to the oncogenic potential Wnt/Frizzled(FZD), growth factor-receptor tyrosine kinases (RTKs), G-proteins/GPCRs. Here we identify Daple, modulator trimeric G-proteins Dishevelled (Dvl)-binding protein as unexpected point convergence...
A new fluorometric and colorimetric dual-modalitye probe L for Cu2+ L-His was constructed based on peptide skeleton via SPPS technology. exhibited highly selective recognition toward through formation of L-Cu2+ ensemble with a 2:1 binding stoichiometry, performed good linear range 0-1.0 μM low detection limit 7.1 nM. Correspondingly, investigated by fluorescence technique which clearly established the high selectivity towards “off-on” response, limits calculated to be approximately 15.3 The...