A5038508779- RNA modifications and cancer
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
- Enzyme Structure and Function
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Enzyme Production and Characterization
- RNA regulation and disease
- Genomics and Rare Diseases
- CRISPR and Genetic Engineering
- Silk-based biomaterials and applications
- Metabolomics and Mass Spectrometry Studies
- Cancer Research and Treatments
- Genetic diversity and population structure
- Chromosomal and Genetic Variations
- Biochemical and Molecular Research
- RNA Interference and Gene Delivery
- ATP Synthase and ATPases Research
- Machine Learning in Bioinformatics
- T-cell and Retrovirus Studies
- Hormonal Regulation and Hypertension
- Glycosylation and Glycoproteins Research
Chongqing Medical University
2023-2025
Wuhan University
2012-2024
Zhongnan Hospital of Wuhan University
2020-2024
Creative Commons
2023
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023
University of California, San Diego
2013-2022
Jiangsu University
2020-2022
Tianjin Medical University
2020
Baylor College of Medicine
2006-2019
Zhejiang Ocean University
2018
Abstract Many proteins regulate the expression of genes by binding to specific regions encoded in genome 1 . Here we introduce a new data set RNA elements human that are recognized RNA-binding (RBPs), generated as part Encyclopedia DNA Elements (ENCODE) project phase III. This class regulatory functions only when transcribed into RNA, they serve sites for RBPs control post-transcriptional processes such splicing, cleavage and polyadenylation, editing, localization, stability translation...
Abstract Genomes encompass all the information necessary to specify development and function of an organism. In addition genes, genomes also contain a myriad functional elements that control various steps in gene expression. A major class these only when transcribed into RNA as they serve binding sites for proteins (RBPs), which act post-transcriptional processes including splicing, cleavage polyadenylation, editing, localization, stability, translation. Despite importance encoded genome,...
Abstract Background Newborn screening (NBS) is an important and successful public health program that helps improve the long-term clinical outcomes of newborns by providing early diagnosis treatment certain inborn diseases. The development next-generation sequencing (NGS) technology provides new opportunities to expand current newborn methodologies. Methods We designed a genetic (NBGS) panel targeting 135 genes associated with 75 disorders multiplex PCR combined NGS. With this panel,...
Abstract Early embryogenesis relies on maternally inherited mRNAs. Although the mechanism of maternal mRNA degradation during maternal-to-zygotic transition (MZT) has been extensively studied in vertebrates, how embryos maintain stability remains unclear. Here, we identify Igf2bp3 as an important regulator zebrafish. Depletion igf2bp3 destabilizes mRNAs prior to MZT and leads severe developmental defects, including abnormal cytoskeleton organization cell division. However, process oogenesis...
To elucidate the relationship between circulating cytokines and prognosis of microsatellite-stable(MSS) colorectal cancer (CRC) patients, we examined correlation cytokine levels tumor immune infiltration microenvironment in this patient population. By conducting a preliminary analysis GEO database, identified five core genes associated with further analyzed their impact on infiltration. We measured serum validated results through immunohistochemical staining common inflammatory cell markers,...
Abstract Background Splicing factors are vital for the regulation of RNA splicing, but some have also been implicated in regulating transcription. The underlying molecular mechanisms their involvement transcriptional processes remain poorly understood. Results Here, we describe a direct role splicing factor RBM22 coordinating multiple steps Polymerase II (RNAPII) transcription human cells. protein widely occupies RNAPII-transcribed gene locus nucleus. Loss promotes RNAPII pause release,...
Abstract We wished to evaluate whether epigenetic modifiers have a beneficial effect on treating experimental periodontitis and mechanisms for regulating the cell fate of mesenchymal stem cells (MSCs) in inflammatory microenvironments. isolated MSCs from healthy inflamed gingival tissues investigate trichostatin A (TSA) could improve osteogenic differentiation resolve inflammation vitro. The tissue regenerative potentials were evaluated when treated with temperature‐dependent,...
A Correction to this paper has been published: https://doi.org/10.1038/s41586-020-03067-w
The growth hormone (GH) gene family represents an erratic and complex evolutionary pattern, involving many events, such as multiple duplications, positive selection, the birth-and-death process conversions. In present study, we cloned sequenced GH-like genes from three species of New World monkeys (NWM). Phylogenetic analysis strongly suggest monophyly for NWM with respect to those Old (OWM) hominoids, indicating that independent duplications have occurred in genes. There are main clusters...
Homozygous Purkinje cell degeneration (pcd) mutant males exhibit abnormal sperm development. Microscopic examination of the testes from pcd(3J)-/- mice at postnatal days 12, 15, 18 and 60 revealed histological differences, in comparison to wild-type mice, which were evident by day 18. Greatly reduced numbers spermatocytes spermatids found adult testes, apoptotic cells identified among differentiating germ after 15. Our immunohistological analysis using an antihuman AGTPBP1 antibody showed...
The aim of this study was to identify the endogenous retrovirus (ERV) sequences in a bovine genome. We subjected genomic DNA PCR with degenerate or ovine ERV (OERV) family-specific primers that aimed amplify retroviral pro/pol region. Sequence analysis 113 clones obtained by revealed 69 were origin. On basis OERV classification system, these from could be divided into beta3, gamma4, and gamma9 families. an additional classified (BERV) gamma7 family. In conclusion, here we report results...