A5103073176- RNA modifications and cancer
- RNA Research and Splicing
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Animal Genetics and Reproduction
- Zebrafish Biomedical Research Applications
- Inflammatory mediators and NSAID effects
- Aquaculture disease management and microbiota
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Fish Ecology and Management Studies
- Adipose Tissue and Metabolism
- Chromosomal and Genetic Variations
- Invertebrate Immune Response Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Renal and related cancers
- Antimicrobial Peptides and Activities
- Estrogen and related hormone effects
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Genetic and Kidney Cyst Diseases
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
Huazhong Agricultural University
2015-2023
Tianjin Medical University General Hospital
2022
First Affiliated Hospital of Zhengzhou University
2013
Abstract Early embryogenesis relies on maternally inherited mRNAs. Although the mechanism of maternal mRNA degradation during maternal-to-zygotic transition (MZT) has been extensively studied in vertebrates, how embryos maintain stability remains unclear. Here, we identify Igf2bp3 as an important regulator zebrafish. Depletion igf2bp3 destabilizes mRNAs prior to MZT and leads severe developmental defects, including abnormal cytoskeleton organization cell division. However, process oogenesis...
ABSTRACT Assembly of a complete Y chromosome is significant challenge in animals with an XX/XY sex-determination system. Recently, we created YY-supermale yellow catfish by crossing XY males sex-reversed females, providing valuable model for Y-chromosome assembly and evolution. Here, assembled highly homomorphic X chromosomes sequencing genomes the YY supermale XX female catfish, revealing their nucleotide divergences only less than 1% same gene compositions. The sex-determining region (SDR)...
Egg quality is a major concern in fish reproduction and development. An effective evaluation of egg prior to fertilization helpful improving the rate survival larva. In this study, we aim identify instructors from combination study rate, hatching embryo malformation gene expression profile.Eggs 25 female were fertilized with sperm same fish. The was determined by rates, divided into three categories, low-quality (< 35%), medium-quality (35 75%), high-quality (> 75%). Due distinct difference...
The high mortality in larval-to-juvenile transition is a big problem aquaculture which related to the shifting from endogenous exogenous feeding. However, underlying causes remain poorly understood. Autophagy, an evolutionary regulated cellular mechanism, highly conserved eukaryotic organisms maintain energy homeostasis against stress including starvation. To investigate whether autophagy plays role during transition, we generated atg7 and beclin1 zebrafish mutant lines using CRISPR/Cas9...
Podocytes are essential elements of the glomerular filtration barrier and relevant to many kidney diseases. But molecular mechanism in podocyte development is still unclear. Wilms tumor protein (WT1) an factor for urogenital system development. Zebrafish have two wt1 genes, naming wt1a wt1b. Here, we examined roles both genes zebrafish embryonic employing CRISPR/Cas9 technology. The homozygous mutants displayed developmental malformations including pericardial edema, yolk sac edema failure...
Background: Lung adenocarcinoma (LUAD) is the most common type of lung cancer and a global public health concern. One-carbon (1C) metabolism plays crucial role in occurrence development multiple types. However, there are limited studies investigating 1C LUAD. This study aims to evaluate prognostic value metabolism-related genes LUAD explore potential correlation these with gene methylation, tumor microenvironment, immunotherapy. Methods: We identified 26 performed Kaplan-Meier Cox regression...
Hybrid sterility has been widely observed in fish species; however, the molecular mechanisms of hybrid are not well understood. In this work, we compared reproductive development yellow catfish (Pelteobagrus fulvidraco, PF) and fulvidraco ♀ × Pelteobagrus vachelli ♂) from embryo to adult at cellular levels. Firstly, developed a pair genetic markers efficiently distinguish PF PV vachelli) their interspecific hybrid. was catfish, as indicated by germ cell-less phenotype defective gonadal...
Abstract High mortality is usually observed during the transition from larvae to juvenile in teleost which related endogenous exogenous feeding. Autophagy an evolutionary regulated cellular mechanism highly conserved eukaryotic organisms maintain energy homeostasis against stress including starvation. To investigate whether autophagy plays a role larval-juvenile transition, we generated atg7 and beclin1 zebrafish mutant lines using CRISPR/Cas9 technology. In this study, both null exhibited...
Abstract Background : Lung adenocarcinoma (LUAD) is the most common type of lung cancer and a global public health concern. One-carbon (1C) metabolism plays crucial role in occurrence development multiple types. However, there are limited studies investigating 1C LUAD. This study aims to evaluate prognostic value metabolism-related genes LUAD explore potential correlation these with gene methylation, tumor microenvironment, immunotherapy. Methods We identified 26 performed Kaplan-Meier Cox...