A5068716686- RNA Research and Splicing
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- Plant Virus Research Studies
- RNA Interference and Gene Delivery
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Plant Disease Resistance and Genetics
- Cardiovascular Syncope and Autonomic Disorders
- Peroxisome Proliferator-Activated Receptors
- MicroRNA in disease regulation
- Chromosomal and Genetic Variations
- Extracellular vesicles in disease
- Nuclear Structure and Function
Wuhan University
2019-2024
Zhongnan Hospital of Wuhan University
2020-2024
People's Hospital of Xinjiang Uygur Autonomous Region
2019
Xinjiang Medical University
2015
UNSW Sydney
2010
Abstract Early embryogenesis relies on maternally inherited mRNAs. Although the mechanism of maternal mRNA degradation during maternal-to-zygotic transition (MZT) has been extensively studied in vertebrates, how embryos maintain stability remains unclear. Here, we identify Igf2bp3 as an important regulator zebrafish. Depletion igf2bp3 destabilizes mRNAs prior to MZT and leads severe developmental defects, including abnormal cytoskeleton organization cell division. However, process oogenesis...
The exosome functions in the degradation of diverse RNA species, yet how it is negatively regulated remains largely unknown. Here, we show that NRDE2 forms a 1:1 complex with MTR4, nuclear cofactor critical for recruitment, via conserved MTR4-interacting domain (MID). Unexpectedly, mainly localizes speckles, where inhibits MTR4 recruitment and degradation, thereby ensures efficient mRNA export. Structural biochemical data revealed interacts MTR4's key residues, locks closed conformation,...
Abstract Background Splicing factors are vital for the regulation of RNA splicing, but some have also been implicated in regulating transcription. The underlying molecular mechanisms their involvement transcriptional processes remain poorly understood. Results Here, we describe a direct role splicing factor RBM22 coordinating multiple steps Polymerase II (RNAPII) transcription human cells. protein widely occupies RNAPII-transcribed gene locus nucleus. Loss promotes RNAPII pause release,...
Significance To ensure efficient and accurate gene expression, pre-mRNA processing mRNA export need to be balanced. SF3b is a core component of U2 snRNP that participates in splicing 3′ pre-mRNAs. Here, we uncovered role promoting by directly binding with the mature recruiting key adaptor THO. Intriguingly, this not dependent on snRNP, but rather enhanced upon disruption as result SF3b–THO interaction recruitment mRNA. Together, our work uncovers an important suggests competition between...
A 77-year-old female patient with type 2 diabetes mellitus mistakenly injected insulin aspart 16 U subcutaneously as glargine before bedtime. One hour later, she developed slow response and paraphasia. Her urgent blood glucose level was 2.8 mmol/L. An IV injection of 50% 40 ml, mask oxygen absorption, continuous ECG monitoring were given immediately. Thirty minutes her increased to 8.4 The adjusted hypoglycemic regimen subcutaneous 8, 10, 8 units 15 3 meals, respectively, 18 Six days fasting...