A5102873063- Advancements in Photolithography Techniques
- Integrated Circuits and Semiconductor Failure Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Extracellular vesicles in disease
- Industrial Vision Systems and Defect Detection
- MicroRNA in disease regulation
- RNA modifications and cancer
- Pancreatic and Hepatic Oncology Research
- Electron and X-Ray Spectroscopy Techniques
- Ultrasound and Hyperthermia Applications
- VLSI and Analog Circuit Testing
- Nanoplatforms for cancer theranostics
- Fluid Dynamics and Mixing
- Photoacoustic and Ultrasonic Imaging
- Semiconductor materials and devices
- Structural Load-Bearing Analysis
- Brain Tumor Detection and Classification
- Composite Structure Analysis and Optimization
- Circular RNAs in diseases
- Oral microbiology and periodontitis research
- Hepatocellular Carcinoma Treatment and Prognosis
- Graphene and Nanomaterials Applications
- Bacterial Infections and Vaccines
- Antifungal resistance and susceptibility
- Cancer-related molecular mechanisms research
Air Force Medical University
2024-2025
Second Affiliated Hospital of Zhejiang University
2016-2024
Tang Du Hospital
2024
Helmholtz-Zentrum Dresden-Rossendorf
2023-2024
Shandong University of Science and Technology
2024
Zhejiang University
2018-2023
Nanjing University of Information Science and Technology
2022
Shenzhen Institute of Information Technology
2019
Harbin Institute of Technology
2019
Center for Excellence in Molecular Cell Science
2019
Liver metastases develop in more than half of the patients with colorectal cancer (CRC) and are associated a poor prognosis. The factors influencing liver metastasis CRC poorly characterized, but this information is urgently needed. We have now discovered that small extracellular vesicles (sEVs; exosomes) derived from can be specifically targeted to tissue induce macrophage polarization toward an interleukin-6 (IL-6)-secreting proinflammatory phenotype. More importantly, we found...
Prospective epidemiological studies have consistently suggested that pancreatic cancer-associated new-onset diabetes mellitus (PC-DM) represents a potential platform for early diagnose of cancer (PC). Despite the performed, mechanism behind this phenomenon remains ambiguous. In study, we explored effects two types exosomes released by murine and ductal epithelial cells on skeletal muscle cells. The results show PC-derived can readily enter C2C12 myotubes, triggering lipidosis glucose intake...
Liver cancer is one of the world's largest causes death to humans. It a difficult task and time consuming identify tissue manually in present scenario. The segmentation liver lesions CT images can be used assess tumor load, plan treatments predict, monitor clinical response. In this paper, Hybridized Fully Convolutional Neural Network (HFCNN) has been proposed for segmentation, which modeled mathematically resolve current issue cancer. For semantic HFCNN as powerful tool analysis. Whereas...
Hepatocellular carcinoma (HCC) is one of the most lethal cancers in world.Sorafenib first small-molecule multi-kinase inhibitors approved by FDA for treatment advanced HCC.Metformin has been demonstrated to have benefit preventing cancer progression.In human recurrent HCCs, NF-E2-related factor 2 (Nrf2) was overexpressed and associated with poor survival.Nrf2 related signaling pathway plays central role mediate cellular resistance sorafenib through protecting HCC cells from ferroptosis.The...
Abstract Increased expression of immune check point genes, such as PD‐L1, is one the main reasons for immunosuppression, especially colon cancer. Development novel therapeutic strategies great importance to improve prognosis. In this study, outer membrane vesicles (OMV) derived from Gram‐negative bacteria are engineered checkpoint blockade nanosystem efficient elicitation anti‐tumor immunity. Briefly, OMVs with Lyp1‐Traptavidin (S52G, R53D mutant streptavidin) fusion protein displayed on...
Abstract Accurately evaluating tumor neoangiogenesis and conducting precise interventions toward an immune‐favorable microenvironment are of significant clinical importance. In this study, a novel nanodroplet termed as the nanodroplet‐based ultrasound contrast agent therapeutic (NDs UCA/Tx ) is designed for imaging neoangiogenesis. Briefly, NDs shell constructed from engineered CMs containing antigen, vascular endothelial growth factor receptor 1 (VEGFR1) extracellular domain 2–3, CD93...
A 3D tracking of individual bubbles in bubble swarms is essential for revealing and understanding interactions clustering mechanisms bubbly flows. In this work, we address issue present a new method deformable based on deep learning models. We also dataset artificial flow sequences to test the tracker, which could be used train future detection or Although developed tracker had difficulties cases with large number bubbles, it showed an overall good performance complete demonstrates potential...
Abstract Multiphase computational fluid dynamics (CFD) simulation is a useful tool to study the hydrodynamics in bubble column if appropriate closure models are known. Systematic assessment of different an ongoing venture that benefits from improved validation data. The present accumulates database on two‐phase flow experiments column. This achieved by using combination particle image velocimetry and shadowgraphy measure liquid velocity field gas dispersion properties simultaneously....
Objective To compare the short- and long-term outcomes of radiofrequency ablation (RFA) versus liver resection chemotherapy for metastases from gastric cancer. Methods We retrospectively evaluated 50 patients who underwent curative gastrectomy local treatments (RFA, n = 20; resection, chemotherapy, 10) 2008 to 2018. Results The each treatment were evaluated. median overall survival (OS) after RFA was similar that (20 vs. 20 months, respectively) longer than 10 respectively). 3-year OS...
A 3D tracking of individual bubbles in bubble swarms is essential for revealing and understanding interactions clusteringmechanisms bubbly fl ows. In this work, we address issue present a new method deformable 3Dbased on deep learning models. We also dataset artifi cial ow sequences to test the tracker, which couldalso be used train future detection or Although developed tracker had di ffi culties cases with largenumber bubbles, it showed an overall good performance complete demonstrates...
Abstract Background The intricacies of nucleotide metabolism within tumor cells specific to colorectal cancer (CRC) remain insufficiently characterized. A nuanced examination particular clusters and their dynamic interplay with the microenvironment (TME) may yield profound insights into these therapeutically auspicious communicative networks. Methods By integrating ten types single-cell enrichment scoring methods, we carried out analysis on CRC cell types, which was validated through four...
Significance To ensure efficient and accurate gene expression, pre-mRNA processing mRNA export need to be balanced. SF3b is a core component of U2 snRNP that participates in splicing 3′ pre-mRNAs. Here, we uncovered role promoting by directly binding with the mature recruiting key adaptor THO. Intriguingly, this not dependent on snRNP, but rather enhanced upon disruption as result SF3b–THO interaction recruitment mRNA. Together, our work uncovers an important suggests competition between...
Hepatic metastasis frequently occurs in patients who have undergone radical pancreatic resection for cancer. Besides chemotherapy, various local treatment approaches targeting hepatic lesions been explored. However, research on radiofrequency ablation (RFA) as a localized therapy is limited. Therefore, we conducted this retrospective study to provide clinical evidence.
Linings and anchor bolts, as common support structures, play a crucial role in ensuring the stability of tunnel surrounding rock. This study aims to investigate elastic–plastic behavior lining-anchor bolt structures deep circular tunnels under static water pressure. Based on Mohr–Coulomb (M-C) criterion equivalent substitution method, this derives solution process for radius plastic zone stress expressions given lining internal Furthermore, through examples, analyzes evolution curve...
Cancers trigger systemic metabolic disorders usually associated with glucose intolerance, which is an initially apparent phenomenon. One of the features pancreatic cancer (PC) reprogramming crosstalk between PC and peripheral tissues (skeletal muscle adipose tissues), emphasized by insulin resistance (IR). Our previous study reported that mice cancer-derived exosomes could induce skeletal cells (C2C12) IR, exosomal microRNAs (miRNAs) may exert important effect. However, underlying mechanism...
In this paper, the optimization problem of clamped-clamped column under buckling load, which was previously dealt with by Tadjbakhsh & Keller (Trans. ASME, J. Appl. Mech., Vol.29, No.1(1962), p.159) and Olhoff Rasmussen(Int. Solids Struct., Vol.13, No.7 (1977), p.605), is reinvestigated. Both numerical analytical methods based on single bimodal formulations are used in investigating behavior optimum eigenvalues corresponding eigenfunctions respect to minimum constraint cross-sectional area....
RNA interference (RNAi)-mediated gene therapy is a promising approach to cure various diseases. However, developing an effective, safe, specific RNAi delivery system remains major challenge. In this study, novel redox-responsive polyetherimide (PEI)-based nanovector, mPEG-SeSe-PEI, was developed and its efficacy evaluated. We prepared three mPEG-SeSe-PEI vector candidates for small interfering glyceraldehyde-3-phosphate dehydrogenase (siGADPH) determined their physiochemical properties...
With the continuous development and improvement of level medical technology in our country recent years, treatment epilepsy has been constantly updated developed. Nerve electrical stimulation is considered to be a very effective method for treating with anxiety depression. There are many traditional methods epilepsy. For example, vagus nerve (VNS) applied earlier, therapeutic effect confirmed, but it will cause serious complications easier uncomfortable; deep brain still immature stage,...