A5101742154- PARP inhibition in cancer therapy
- Toxin Mechanisms and Immunotoxins
- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Biochemical and Molecular Research
- Ophthalmology and Visual Impairment Studies
- Chronic Lymphocytic Leukemia Research
- Corneal surgery and disorders
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Intraocular Surgery and Lenses
- Cancer, Lipids, and Metabolism
- HER2/EGFR in Cancer Research
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Signaling Pathways in Disease
- Cancer Treatment and Pharmacology
- DNA Repair Mechanisms
- Advanced Photonic Communication Systems
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
Chongqing Medical University
2016-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022-2025
Sun Yat-sen University Cancer Center
2014-2025
Sun Yat-sen University
2014-2025
National Institute for Viral Disease Control and Prevention
2023-2025
Shandong Agricultural University
2025
Henan Institute of Science and Technology
2024
Affiliated Eye Hospital of Wenzhou Medical College
2022-2024
Wenzhou Medical University
2022-2024
National Clinical Research Center for Digestive Diseases
2022-2024
Boceprevir is a hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor that currently being evaluated in combination with peginterferon alfa-2b and ribavirin phase 3 studies. The clinical resistance profile of boceprevir not characterized detail so far. NS3 domain viral RNA was cloned from HCV genotype 1–infected patients (n = 22). A mean number 47 clones were sequenced before, at the end, after treatment 400 mg twice or three times daily for 14 days genotypic,...
Abstract The synthesis of large lattice mismatch metal‐semiconductor core–shell hetero‐nanostructures remains challenging, and thus the corresponding optical properties are seldom discussed. Here, we report gold‐nanorod‐seeded growth Au–CdS hetero‐nanorods by employing Ag 2 S as an interim layer that favors CdS shell formation through a cation‐exchange process, subsequent growth, which can form complete structures with controllable thickness. Exciton–plasmon interactions observed in nanorods...
Previous studies reported that positive phases of the Indian Ocean Dipole (IOD) tend to accompany El Niño during boreal autumn. Here we show Niño/IOD relationship can be better understood when considering two different flavors. Eastern Pacific events exhibit a strong correlation with IOD dependent on their magnitude. In contrast, between Central (CP) and depends mainly zonal location sea surface temperature anomalies rather than CP lying farther west normal are not accompanied by significant...
Alcoholic liver disease (ALD) results from continuous and heavy alcohol consumption. The current treatment strategy for ALD is based on withdrawal coupled with antioxidant drug intervention, which a long process poor efficacy low patient compliance. Alcohol-induced CYP2E1 upregulation has been demonstrated as key regulator of ALD, but knockdown in humans was impractical, pharmacological inhibition by clinically relevant approach treating not shown. In this study, we developed RNAi...
A cheap polymer with a robust structure was used to produce metal-free carbon materials record high mass activity.
Investigating immune memory to vaccinia virus and pre-existing immunity mpox (MPXV) among the population is crucial for global response this ongoing epidemic. Blood was sampled from vaccinees inoculated with Tiantan (VTT) strain born before 1981 unvaccinated control subjects since 1982. After at least 40 years of inoculation, 60% or 5% VTT possess neutralizing antibodies (NAbs) MPXV, 50% having T cell protein antigens. Notably, 46.7% show responses MPXV. Broad CD8+ reactivities MPXV are...
Objective: Spindle pole body component 25 (SPC25) is an important cyclin involved in chromosome segregation and spindle dynamics regulation during mitosis. However, the role of SPC25 lung adenocarcinoma (LAUD) unclear. Materials Methods: The differential expression tumor samples normal was analyzed using TIMER, TCGA, GEO databases, correlation between its clinicopathological features prognosis LUAD patients. Biological pathways that may be enriched by were GSEA. In vitro cell experiments...
We propose and experimentally demonstrate a spurious level phase noise improved Fourier domain mode-locked optoelectronic oscillator (FDML-OEO) based on self-injection-locking (SIL) technique. The scheme applies dual-loop FDML-OEO structure, in which long optical fiber delay loop is used to injection-lock the OEO with short oscillating loop. SIL achieved so as of tuned at integral multiple oscillation spur suppression ratio wideband linear frequency modulated (LFM) signal generated by can be...
Abstract The genetic etiology and underlying mechanism of autism spectrum disorder (ASD) remain elusive. SHANK family genes ( SHANK1/2/3 ) are well known ASD-related genes. However, little is about how missense mutations contribute to ASD. Here, we aimed clarify the molecular multilevel neuropathological features induced by Shank1 in knock-in (KI) mice. In this study, sequencing SHANK1 gene a cohort 615 ASD patients 503 controls, identified an ASD-specific recurrent mutation, c.2621 G > A...
Introduction: Drug-induced QT prolongation and (or) Torsade de Pointes (TdP) is a well-known serious adverse reaction (ADR) for some drugs, but the widely recognized comprehensive landscape of culprit-drug TdP currently lacking. Aim: To identify top drugs reported in association with provide information clinical practice. Method: We reviewed reports related to FDA Adverse Event Reporting System (FAERS) database from January 1, 2004 December 31, 2022, summarized potential causative drug list...
The aim of this work is to evaluate the accuracy Barrett Universal II (BU II), Emmetropia verifying optical (EVO) 2.0, Haigis, Hoffer Q, QST (Savini/Taroni) (HQST), Holladay 1, Kane, Ladas Super, Sanders–Retzlaff–Kraff/theoretical (SRK/T), and T2 intraocular lens (IOL) power formulas for calculating spherical equivalent (SE) toric IOL. This study enrolled consecutive patients who underwent phacoemulsification IOL implantation at Eye Hospital Wenzhou Medical University in Hangzhou from 2015...
To elucidate the relationship between circulating cytokines and prognosis of microsatellite-stable(MSS) colorectal cancer (CRC) patients, we examined correlation cytokine levels tumor immune infiltration microenvironment in this patient population. By conducting a preliminary analysis GEO database, identified five core genes associated with further analyzed their impact on infiltration. We measured serum validated results through immunohistochemical staining common inflammatory cell markers,...
Timely identification and discontinuation of culprit-drug is the cornerstone clinical management drug-induced acute pancreatitis (AP), but comprehensive landscape AP culprit-drugs still lacking. To provide current overview to guide practice, we reviewed adverse event (AE) reports associated with in US Food Drug Administration (FDA) Adverse Event Reporting System (FAERS) database from 2004 2022, summarized a potential list its corresponding AE report quantity proportion. The...
RAB3B is essential for the transportation and secretion within cells. Its increased expression linked to development progression of various malignancies. However, understanding RAB3B's involvement in carcinogenesis mostly limited specific cancer subtypes. Hence, exploring regulatory roles molecular mechanisms through comprehensive datasets might offer innovative approaches managing clinical cancer. To examine potential cancer, we analyzed data from sources including The Cancer Genome Atlas...
Primary breast diffuse large B‐cell lymphoma ( PB ‐ DLBCL ) is a rare subtype of with limited data on patterns failure. This multicenter study aimed to define the optimum treatment strategy and failure for patients. We retrospectively reviewed 108 patients from 21 Chinese medical centers. Only localized disease (involvement lymph nodes) were included. After median follow‐up 3.2 years, 32% developed progression or relapse. A continuous pattern relapse was observed, characterized by frequent...
Arginine adenosine diphosphate (ADP)-ribosyl-transferase 1 (ART1) is known to play an important role in many physiological and pathological processes. Previous studies have demonstrated that ART1 promotes proliferation, invasion metastasis colon carcinoma. However, it was unclear whether involved angiogenesis cases of colorectal cancer (CRC). In the present study, lentiviral vector‑mediated ART1‑cDNA or ART1-shRNA were transfected into LoVo cells, cells with ART1-cDNA co-cultured human...
Arginine-specific ADP-ribosytransferases 1 (ART1) is able to modify the arginine of specific proteins by mono-ADP-ribosylation. We previously reported that expression ART1 in human colon adenocarcinoma tissues was higher than adjacent tissues. Herein, we primarily revealed could regulate epithelial-mesenchymal transition (EMT) and, therefore, development carcinoma. In CT26 cells, which overexpressed lentiviral transfection, following were promoted: alterations spindle-like non-polarization,...
This paper proposes a sensitive, sample preparation-free, rapid, and low-cost method for the detection of B-rapidly accelerated fibrosarcoma (BRAF) gene mutation involving substitution valine to glutamic acid at codon 600 (V600E) in colorectal cancer (CRC) by near-infrared (NIR) spectroscopy conjunction with counter propagation artificial neural network (CP-ANN). The NIR spectral data from 104 paraffin-embedded CRC tissue samples consisting an equal number BRAF V600E mutant wild-type ones...