A5101733836- Pharmacovigilance and Adverse Drug Reactions
- Computational Drug Discovery Methods
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- 14-3-3 protein interactions
- Pharmacogenetics and Drug Metabolism
- MicroRNA in disease regulation
- Drug-Induced Adverse Reactions
- GDF15 and Related Biomarkers
- Genomics, phytochemicals, and oxidative stress
- HER2/EGFR in Cancer Research
- Vitamin D Research Studies
- Antimicrobial Resistance in Staphylococcus
- Health Systems, Economic Evaluations, Quality of Life
- Hormonal and reproductive studies
- Neuroendocrine Tumor Research Advances
- Cancer Treatment and Pharmacology
- Pancreatitis Pathology and Treatment
- Natural Antidiabetic Agents Studies
- Endometriosis Research and Treatment
- Acute Lymphoblastic Leukemia research
- Clostridium difficile and Clostridium perfringens research
- Cholinesterase and Neurodegenerative Diseases
- Drug-Induced Hepatotoxicity and Protection
- Rheumatoid Arthritis Research and Therapies
Second Affiliated Hospital of Jilin University
2024
Chongqing Medical University
2020-2024
Chengdu Normal University
2021
Army Medical University
2020
Abstract Background Alzheimer’s disease (AD) is the most common type of neurodegenerative in contemporary era, and it still clinically incurable. Eriodictyol, a natural flavonoid compound that mainly present citrus fruits some Chinese herbal medicines, has been reported to exert anti-inflammatory, antioxidant, anticancer neuroprotective effects. However, few studies have examined anti-AD effect molecular mechanism eriodictyol. Methods APP/PS1 mice were treated with eriodictyol cognitive...
Glioma is the most common type of malignant brain tumor. Due to its highly aggressive and metastatic features, glioma associated with poor prognosis a lack effective treatments. Eriodictyol, natural flavonoid compound, has been reported possess anti-inflammatory antioxidant effects. However, anti-tumor effects eriodictyol underlying mechanisms have rarely reported. In this study, we found that activity in lung, colon, breast, pancreas, liver cancer, significantly cell lines. Eriodictyol...
Background: Sound drug safety information is important to optimize patient management, but the widely recognized comprehensive landscape of culprit-drugs that cause severe cutaneous adverse reactions (SCARs) currently lacking. Objective: The main aim study provide a for SCARs guide clinical practice. Methods: We analyzed reports associated with in FDA Adverse Event Reporting System database between 1 January 2004 and 31 December 2021 compiled list drugs potentially serious skin toxicity....
Introduction: Drug-induced QT prolongation and (or) Torsade de Pointes (TdP) is a well-known serious adverse reaction (ADR) for some drugs, but the widely recognized comprehensive landscape of culprit-drug TdP currently lacking. Aim: To identify top drugs reported in association with provide information clinical practice. Method: We reviewed reports related to FDA Adverse Event Reporting System (FAERS) database from January 1, 2004 December 31, 2022, summarized potential causative drug list...
Timely identification and discontinuation of culprit-drug is the cornerstone clinical management drug-induced acute pancreatitis (AP), but comprehensive landscape AP culprit-drugs still lacking. To provide current overview to guide practice, we reviewed adverse event (AE) reports associated with in US Food Drug Administration (FDA) Adverse Event Reporting System (FAERS) database from 2004 2022, summarized a potential list its corresponding AE report quantity proportion. The...
Antibacterial drug exposure (ADE) is a well-known potential risk factor for Clostridium difficile infection (CDI), but it remains controversial which certain antibacterial drugs are associated with the highest of CDI occurrence. To summarize ADE, we reviewed reports related to ADE in FDA Adverse Event Reporting System database and conducted disproportionality analysis detect adverse reaction (ADR) signals drugs. A total 8063 were identified, involved 73 Metronidazole was greatest number...
Liujunzi Decoction (LJZD) is a potential clinical treatment for Breast Cancer (BC), but the active ingredients and mechanisms underlying its effectiveness remain unclear.
Background: Xiaochaihu (XCH) decoction is a traditional Chinese prescription that has been recorded in the pharmacopeia of People's Republic China. In China, XCH used clinically to treat variety tumors, including breast cancer. However, its potential mechanism action still undefined. Methods: The chemical compounds were identified via Q Exactive Orbitrap LC-MS/MS. Then, we screened active ingredients and targets from Traditional Medicine Systems Pharmacology Database Analysis Platform...
Abstract Because of its unpredictable side effects and efficacy, the anticancer drug docetaxel (DTX) requires improved characterisation pharmacokinetic profiles through population studies. A sensitive rugged LC–MS/MS method for detection DTX in human plasma was developed optimised using paclitaxel as an internal standard (IS). The samples underwent rapid extraction hybrid solid‐phase extraction‐protein precipitation. analyte IS were separated with isocratic system on a Zorbax Eclipse Plus C...
Hepatocellular carcinoma is a kind of cancer with strong invasion, high incidence rate and mortality, poor prognosis. At the time diagnosis, most patients are already in advanced stages tumor have lost chance for radical surgical treatment. Advanced hepatocellular treatment has gradual transition from systemic chemotherapy to targeted therapy, immunotherapy, combination especially immune checkpoint inhibitor-based immunotherapy such as bevacizumab monoclonal antibodies other drugs, or TACE,...
At present, drug development for treating Alzheimer's disease (AD) is still highly challenging. Eriodictyol (ERD) has shown great potential in AD, but its molecular mechanism unknown.
Background The comprehensive quantitative and comparative risk data of drug-induced erectile dysfunction (ED) are still lacking, this study aims to supplement information.
The utility of pharmacist consultation for drug-induced liver injury (DILI) management has not been explored. This retrospective cohort study evaluated the impact a active (PAC) service on and outcome in patients with DILI. Consecutive meeting clinical biochemical criteria DILI were enrolled at tertiary teaching hospital between 1 January 2020 30 April 2022. Roussel Uclaf Causality Assessment Method was used to assess causality drug use each suspected patient. Included grouped according...
Abstract Background Alzheimer's disease (AD) is the most common type of neurodegenerative in contemporary era, and it still clinically incurable. Eriodictyol, a natural flavonoid compound mainly exists citrus fruits some Chinese herbal medicine, has been reported with its effect anti-inflammatory, antioxidant, anti-cancer neuroprotective effects. However, there are few studies on anti-AD molecular mechanism eriodictyol. Methods APP/PS1 mice were treated eriodictyol cognitive function was...