A5103050971- Pharmacovigilance and Adverse Drug Reactions
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Phagocytosis and Immune Regulation
- Drug-Induced Adverse Reactions
- Computational Drug Discovery Methods
- Chemotherapy-related skin toxicity
- Indoor and Outdoor Localization Technologies
- Neutropenia and Cancer Infections
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Caveolin-1 and cellular processes
- Listeria monocytogenes in Food Safety
- Lung Cancer Research Studies
- RNA modifications and cancer
- Pharmacogenetics and Drug Metabolism
- Clostridium difficile and Clostridium perfringens research
- Methemoglobinemia and Tumor Lysis Syndrome
- Antibiotic Use and Resistance
- Influenza Virus Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pneumonia and Respiratory Infections
- Immune Response and Inflammation
- Pharmaceutical Practices and Patient Outcomes
- Inertial Sensor and Navigation
Chongqing Medical University
2022-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Chengdu Medical College
2024
North Sichuan Medical University
2024
Shandong University
2019
Taishan Medical University
2017
Kunming General Hospital of Chengdu Military Command
2009-2014
Chengdu Military General Hospital
2009-2014
Background: Sound drug safety information is important to optimize patient management, but the widely recognized comprehensive landscape of culprit-drugs that cause severe cutaneous adverse reactions (SCARs) currently lacking. Objective: The main aim study provide a for SCARs guide clinical practice. Methods: We analyzed reports associated with in FDA Adverse Event Reporting System database between 1 January 2004 and 31 December 2021 compiled list drugs potentially serious skin toxicity....
Hepatocellular carcinoma is the most common form of primary liver cancer and poses a significant challenge to medical community because its high mortality rate. In recent years, ferroptosis, unique cell death, has garnered widespread attention. Ferroptosis, which characterized by iron-dependent lipid peroxidation mitochondrial alterations, closely associated with pathological processes various diseases, including hepatocellular carcinoma. Long non-coding RNAs (lncRNAs), are type functional...
Introduction: Drug-induced QT prolongation and (or) Torsade de Pointes (TdP) is a well-known serious adverse reaction (ADR) for some drugs, but the widely recognized comprehensive landscape of culprit-drug TdP currently lacking. Aim: To identify top drugs reported in association with provide information clinical practice. Method: We reviewed reports related to FDA Adverse Event Reporting System (FAERS) database from January 1, 2004 December 31, 2022, summarized potential causative drug list...
Timely identification and discontinuation of culprit-drug is the cornerstone clinical management drug-induced acute pancreatitis (AP), but comprehensive landscape AP culprit-drugs still lacking. To provide current overview to guide practice, we reviewed adverse event (AE) reports associated with in US Food Drug Administration (FDA) Adverse Event Reporting System (FAERS) database from 2004 2022, summarized a potential list its corresponding AE report quantity proportion. The...
Antibacterial drug exposure (ADE) is a well-known potential risk factor for Clostridium difficile infection (CDI), but it remains controversial which certain antibacterial drugs are associated with the highest of CDI occurrence. To summarize ADE, we reviewed reports related to ADE in FDA Adverse Event Reporting System database and conducted disproportionality analysis detect adverse reaction (ADR) signals drugs. A total 8063 were identified, involved 73 Metronidazole was greatest number...
The use of antineoplastic agents is one the important triggers tumor lysis syndrome (TLS), but there still a lack comprehensive understanding that may trigger TLS and risk differences between different agents.
This study was designed to explore the protective effect of D4F, an apolipoprotein A-I mimetic peptide, on nuclear factor-κB (NF-κB)-dependent Fas/Fas ligand (FasL) pathway-mediated apoptosis in macrophages induced by oxidized low-density lipoprotein (ox-LDL). Our results showed that ox-LDL apoptosis, NF-κB P65 translocation and upregulation Fas/FasL pathway-related proteins, including Fas, FasL, Fas-associated death domain proteins (FADD), caspase-8 caspase-3 RAW264.7 macrophages, whereas...
TLR2 signaling plays a critical protective role against acute Listeria monocytogenes (Lm) infection by up-regulating inflammatory cytokines and promoting macrophage antimicrobial capabilities. However, the underlying mechanism which regulates hepatic macrophage-mediated anti-Lm immune responses remains poorly understood. In this study, we found that both absolute number proportion of monocyte/macrophage (Mo/MΦ) in liver spleen Tlr2-/- mice were significantly lower compared to wild type mice....
In this paper, we introduce a novel factor-graph based multi-sensor fusion algorithm that optimally estimates camera-odometer extrinsic calibration (6 DOF rigid body transformation between the two sensors) and localization aided by MEMS gyroscope measurements. particular, rigorously derive node factors from camera odometer Moreover, due to significantly higher frequency of gyro than those odometer, develop analytical preintegration using unit quaternions provide relative-rotation factor...
Background and aim: Infectious disease (ID) consultation can improve multidrug-resistant organism (MDRO) treatment outcomes. However, the impact of clinical pharmacists’ ID on MDRO therapy, especially early initiation, has not been reported. In this study, we try to explore pharmacist active (PEAC) patient management. Methods: We conducted a prospective historical controlled study based PEAC in patients. The retrospective control group was patients hospitalized 18 months before after...
Homotypic cell-in-cell structures (hoCICs) are associated with tumor proliferation, invasion, and metastasis is considered a promising prognostic marker in various cancers. However, the role of hoCICs non-small cell lung cancer (NSCLC) remains unclear. Tumor tissue sections were obtained from 411 NSCLC patients. We analyzed relationship between clinicopathological variables number hoCICs. LASSO multivariate Cox regression analysis employed to identify factors for NSCLC. The impact on overall...
Background The comprehensive quantitative and comparative risk data of drug-induced erectile dysfunction (ED) are still lacking, this study aims to supplement information.
The utility of pharmacist consultation for drug-induced liver injury (DILI) management has not been explored. This retrospective cohort study evaluated the impact a active (PAC) service on and outcome in patients with DILI. Consecutive meeting clinical biochemical criteria DILI were enrolled at tertiary teaching hospital between 1 January 2020 30 April 2022. Roussel Uclaf Causality Assessment Method was used to assess causality drug use each suspected patient. Included grouped according...
Objective To investigate the efficacy of balloon dilatation in treatment traumatic biliary stricture(TBS).Methods Eighty-one patients with TBS who had been admitted into General Hospital Chengdu Command from February 1997 to 2007 were divided 2 groups.In control group,40 underwent choledoco-jeiunostomy T tube stenting anastomotic stoma for 6 months.In group,41 received implantation catheters along two arms stoma.The different surgical procedures analyzed by chi-square test.Results Seven...
Objective To investigate the role of sphingosine kinase 1 (SphK1) peripheral blood leucocytes in inflammatory response patients with acute pancreatitis (AP).Methods Thirty AP were enrolled and divided into severe (SAP) group (n =13) mild (MAP) =17).Ten healthy volunteers selected as control group.The serum levels tumor necrosis factor (TNF)-α,interleukin (IL)-6,and expression SphK1 mRNA enzymatic activity detected at 48 h,72 h,5 day,and 7 day after attack AP.Results At h 5 day,the lowest...