A5107930001- RNA modifications and cancer
- Circular RNAs in diseases
- Diet, Metabolism, and Disease
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Discourse Analysis in Language Studies
- Immune Cell Function and Interaction
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Second Language Acquisition and Learning
- Bone Metabolism and Diseases
- Metabolism, Diabetes, and Cancer
- Plant Stress Responses and Tolerance
- Parathyroid Disorders and Treatments
- Computational Drug Discovery Methods
- EFL/ESL Teaching and Learning
- Natural Compounds in Disease Treatment
- Natural Language Processing Techniques
- MicroRNA in disease regulation
- Nitrogen and Sulfur Effects on Brassica
- Text and Document Classification Technologies
- Research studies in Vietnam
- Macrophage Migration Inhibitory Factor
- Gallbladder and Bile Duct Disorders
Linyi People's Hospital
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2025
China Academy of Chinese Medical Sciences
2025
Chongqing Medical University
2023-2024
Hubei University of Medicine
2023-2024
Taihe Hospital
2024
University of South China
2024
University of Science and Technology Beijing
2022-2024
Nantong University
2024
Guilin Medical University
2024
Cervical cancer (CC) is one of the most common gynecological malignancies with poor prognosis for advanced CC patients. LRRC8A a volume-regulated anion channel protein involved in cellular homeostasis, but its role remains largely unknown. In this study, we found that elevated and associated prognosis. maintains cell survivals under hypotonic condition, promotes tumorigenesis through apoptosis suppression vitro vivo. Notably, upregulated by NSUN2-mediated m5C modification. modified-LRRC8A...
Manganese (Mn) is an essential trace element for maintaining bodily functions. Excessive exposure to Mn can pose serious health risks humans and animals, particularly the nervous system. While has been implicated as a neurotoxin, exact mechanism of its toxicity remains unclear. Ferroptosis form programmed cell death that results from iron-dependent lipid peroxidation. It plays role in various physiological pathological cellular processes may be closely related Mn-induced neurotoxicity....
High oxidative stress and inflammatory cell infiltration are major causes of the persistent bone erosion difficult tissue regeneration in rheumatoid arthritis (RA). Triptolide (TPL) has become a highly anticipated anti-rheumatic drug due to its excellent immunomodulatory anti-inflammatory effects. However, sudden accumulation caused by binding "stimulus-response" "drug release" general smart delivery system is meet shortcoming extreme toxicity demand for long-term administration TPL. Herein,...
Rheumatoid arthritis (RA) is a common autoimmune joint disease characterized by persistent synovial inflammation and cartilage damage. The current clinical treatments primarily utilize drugs such as triptolide (TP) to address inflammation, yet they are unable directly repair damaged cartilage. Furthermore, the often undermines effectiveness of traditional strategies, preventing them from achieving optimal outcomes. To tackle this challenge, study successfully developed drug-loaded...
Attenuated insulin-sensitivity (IS) is a characteristic of type 2 diabetes (T2D) and closely linked to non-alcoholic fatty liver disease (NAFLD). In recent years, many surrogate markers IS have emerged predict NAFLD. A natural log transformation the glucose disposal rate (loge GDR) has been proposed as new model for in patients with T2D. Our aim explore correlation between loge GDR NAFLD normoalbuminuric total 1227 T2D were involved our study. was evaluated by ultrasound. Biochemical...
Aims Non-alcoholic fatty liver disease (NAFLD) is closely related to type 2 diabetes (T2D), with reduced insulin sensitivity being a key factor in their disrupted metabolic processes. The single point estimator (SPISE) novel index. This study aims explore the association between SPISE and NAFLD T2D population. Methods included total of 2,459 patients T2D. was calculated based on high density lipoprotein-cholesterol (HDL-c), triglycerides (TG), body mass index (BMI). Participants were...
Diabetes is an independent risk factor for thyroid nodules (TNs), however, the influencing factors of TNs have not been fully clarified under condition diabetes. Previous studies shown a connection between pituitary-thyroid hormone (TH) functions and in different populations. However, potential link euthyroid patients with diabetes unclear. We aimed to explore correlates type 2 (T2D) patients. This cross-sectional study included 1965 adults T2D. Clinical biochemical data, including TH...
Aims Studies confirm that microalbuminuria (MAU) can not only predict diabetic kidney disease (DKD) but also indicate of systemic vascular endothelial injury. Thyroid hormones (TH) have been reported to be associated with various cardiovascular diseases and cell damage. Currently, few studies the association between free thyroxine (FT4) triiodothyronine (FT3) ratio MAU. The purpose this study was investigate FT4/FT3 MAU in euthyroid patients type 2 diabetes mellitus (T2DM). Methods This...
Several lipid metabolism-related profiles have been explored for their association with obesity, but no consensus has reached. Therefore, this study aimed to comprehensively analyze the correlation between conventional and unconventional visceral fat area (VFA) in overweight/obese patients type 2 diabetes mellitus (T2DM). Emphasizing overall relationship metabolism accumulation. This cross-sectional included 1288 T2DM patients, VFA measured using bioelectrical impedance analysis obesity...
BdGF14a, a 14-3-3 gene from Brachypodium distachyon, induced by salt, H2O2, and abscisic acid (ABA), improved tolerance to drought salt in tobacco, with higher survival rate longer roots under these stresses. Additionally, physiological index analyses showed that the heterologous expression of BdGF14a levels antioxidant enzymes their activities, leading lighter DAB NBT staining, denoting decreased H2O2 content. lower MDA content ion leakage indicated enhanced cell membrane stability....
Previous studies have revealed that miRNAs participate in the pathogenesis of ovarian cancer; however, whether miR-600 is also involved remains unclear. In this study, we aimed to investigated role cancer progression. Here, expression was significantly upregulated tissues and stem cells. Functional showed promoted cell stemness, proliferation metastasis. Mechanistic Kruppel like factor 9 (KLF9) indicated as target miR-600. The luciferase reporter assay suggested directly bound...
Abstract Platinum-based chemotherapy is the standard postoperative adjuvant treatment for ovarian cancer (OC). Despite initial response to chemotherapy, 85% of advanced OC patients will have recurrent disease. Relapsed disease and platinum resistance are major causes death in patients. In this study, we compared global regulation alternative polyadenylation (APA) platinum-resistant platinum-sensitive tissues by analyzing a set single-cell RNA sequencing (scRNA-seq) data from public databases...
Substantial evidence has established a strong association between non-alcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (T2DM) and insulin resistance (IR). Insulin metabolic score (METS-IR) is new more effective comprehensive indicator for measuring IR. Our aim was to investigate the relationship METS-IR NAFLD in T2DM population.
Abstract Background The incidence of ovarian cancer ranks third among gynecologic malignancies, but the mortality rate first. Methods expression GAS5 is low in and associated with survival patients according to public databases. overexpression inhibited malignancy by affecting proliferation migratory abilities OVCAR3 A2780 cells. increased cell apoptosis, cells were blocked G1 phase as assessed flow cytometry. Results We found that hnRNPK was a potential target gene, which regulated...
Abstract Acetyl‐CoAacyltransferase2 (ACAA2) is a key enzyme in the fatty acid oxidation pathway that catalyzes final step of mitochondrial β oxidation, which plays an important role metabolism. The expression ACAA2 closely related to occurrence and malignant progression tumors. However, function ovarian cancer unclear. level prognostic value were analyzed by databases. Gain loss carried out explore cancer. RNA‐seq bioinformatics methods applied illustrate regulatory mechanism ACAA2....
Recent evidence has shown that T cell exhaustion is implicated in Allergen-specific Immunotherapy (AIT). However, how plays a role AIT far from clear. Our study aimed to investigate associated with allergen exposure during mice. Ovalbumin (OVA) - sensitized C57BL/6J asthma mouse and models were constructed. Quantitative real-time PCR (qRTPCR) flow cytometry used monitor the occurrence of local systemic CD4
Abscisic acid (ABA), a phytohormone, enacts cardinal function in coping with abiotic stress. 14-3-3 proteins can interact ABA-responsive-element-binding transcription factors (ABFs), chief constituent of ABA signaling, and play critical roles the dehydration response involving signaling. Meanwhile, whether how regulate signaling to respond aridity stress is yet be fully investigated. Herein, BdGF14g, gene induced by ABA, H2O2, PEG treatments, was identified Brachypodium distachyon (B....
Leadership behavior of classroom teachers has a significant impact on students’ academic success. However, little empirical research this subject been undertaken in China. By developing truth tables and doing necessary computations, study examines the influence differential combinations parameters connected to class teachers’ qualities leadership student performance. It discovered that democratic displayed by is most popular among students helpful achievement; numerous linked characteristics...
The aim of this study was to explore the associations moderate-to-vigorous-intensity physical activity (MVPA) time and sedentary (SED) with a history cardiovascular disease (CVD) multifactorial (i.e., blood pressure (BP), body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), glycated hemoglobin A1c (HbA1c)) control status among type 2 diabetes mellitus (T2DM) patients in China. A cross-sectional analysis 9152 people from Multifactorial Intervention on Type Diabetes (MIDiab)...