A5008903462- Lipid metabolism and disorders
- Growth Hormone and Insulin-like Growth Factors
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet, Metabolism, and Disease
- Thyroid Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- Adipokines, Inflammation, and Metabolic Diseases
- Thyroid Cancer Diagnosis and Treatment
- Gout, Hyperuricemia, Uric Acid
- Chronic Kidney Disease and Diabetes
- Regulation of Appetite and Obesity
- Cardiovascular Disease and Adiposity
- Renal Diseases and Glomerulopathies
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Polyomavirus and related diseases
- Head and Neck Anomalies
- Vascular Malformations and Hemangiomas
- Diabetes Management and Research
- Parvovirus B19 Infection Studies
Affiliated Hospital of Jining Medical University
2018-2025
Linyi People's Hospital
2023-2025
Qingdao University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2012-2019
Chongqing Medical University
2012-2019
Abstract Objective To investigate whether the mRNA expression of thyroglobulin ( TG ) and TSH receptor TSHR in lymph node could be used to diagnose metastasis patients with papillary thyroid cancer (PTC). Subjects methods Around 156 paraffin samples nodes from 89 PTC after surgery were collected, expressions detected by nested qPCR. Results Compared results confirmed histopathology, 86 out 87 tissues ectopically expressed mRNA, while 66 69 non‐metastasis did not express mRNA. The specificity...
Attenuated insulin-sensitivity (IS) is a characteristic of type 2 diabetes (T2D) and closely linked to non-alcoholic fatty liver disease (NAFLD). In recent years, many surrogate markers IS have emerged predict NAFLD. A natural log transformation the glucose disposal rate (loge GDR) has been proposed as new model for in patients with T2D. Our aim explore correlation between loge GDR NAFLD normoalbuminuric total 1227 T2D were involved our study. was evaluated by ultrasound. Biochemical...
Aims Non-alcoholic fatty liver disease (NAFLD) is closely related to type 2 diabetes (T2D), with reduced insulin sensitivity being a key factor in their disrupted metabolic processes. The single point estimator (SPISE) novel index. This study aims explore the association between SPISE and NAFLD T2D population. Methods included total of 2,459 patients T2D. was calculated based on high density lipoprotein-cholesterol (HDL-c), triglycerides (TG), body mass index (BMI). Participants were...
ABSTRACT Type 2 diabetes (T2D) and hypertension often coexist, insulin resistance (IR) plays an important role in their pathological progression. An increasing number of studies have focused on the relationship between different IR indices hypertension. A natural log transformation glucose disposal rate (log e GDR) has been proposed as a new model for sensitivity patients with T2D. The study aimed to explore GDR T2D patients. This cross‐sectional included 1544 Chinese Clinical biochemical...
Diabetes is an independent risk factor for thyroid nodules (TNs), however, the influencing factors of TNs have not been fully clarified under condition diabetes. Previous studies shown a connection between pituitary-thyroid hormone (TH) functions and in different populations. However, potential link euthyroid patients with diabetes unclear. We aimed to explore correlates type 2 (T2D) patients. This cross-sectional study included 1965 adults T2D. Clinical biochemical data, including TH...
Aims Studies confirm that microalbuminuria (MAU) can not only predict diabetic kidney disease (DKD) but also indicate of systemic vascular endothelial injury. Thyroid hormones (TH) have been reported to be associated with various cardiovascular diseases and cell damage. Currently, few studies the association between free thyroxine (FT4) triiodothyronine (FT3) ratio MAU. The purpose this study was investigate FT4/FT3 MAU in euthyroid patients type 2 diabetes mellitus (T2DM). Methods This...
Diabetic cardiomyopathy is one of the most important cardiac complications associated with diabetes. However, mechanisms underlying diabetic remain unclear. The PARP1, SIRT1, and mTOR pathways have been implicated in diseases, they are also 1,25(OH)2 D3 was recently recognized as a potential PARP1inhibitor macrophage cell line. aim our study to investigate whether can improve through vitamin D receptor (VDR)-dependent mechanism PARP1/SIRT1/mTOR pathway.1,25(OH)2 -treated rats displayed...
We assessed the correlation between visceral adiposity index (VAI; a useful indicator of adipose distribution and function) homeostatic model assessment insulin resistance (HOMA-IR) in participants with normal waist circumference. A cross-sectional study was conducted, which included 1834 Chinese adults. The blood pressure, anthropometric measurements, fasting postprandial glucose, insulin, lipid profiles were measured. VAI HOMA-IR calculated. Participants divided into 4 groups according to...
Substantial evidence has established a strong association between non-alcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (T2DM) and insulin resistance (IR). Insulin metabolic score (METS-IR) is new more effective comprehensive indicator for measuring IR. Our aim was to investigate the relationship METS-IR NAFLD in T2DM population.
The purpose of the present study was to observe relationship between serum α-klotho (KL) protein level and diabetic retinopathy (DR), further examine effects KL on apoptosis induced by palmitic acid (PA) in human retinal endothelial cells.
The aim of this study was to examine the relationship between insulin-like growth factor-1 (IGF-1) and serum uric acid (UA) in Chinese children adolescents with idiopathic short stature (ISS).A cross-sectional 91 ISS performed. Anthropometric measurements biochemical parameters were tested. standard deviation score IGF-1 (IGF-1 SDS) calculated.A univariate analysis displayed a significant positive correlation SDS UA (P = 0.004). In multivariate piecewise linear regression, levels increased...
Elevated low-density lipoprotein cholesterol (LDL-C) levels in childhood have recently been found to be the strongest predictive risk factor for coronary artery disease adulthood. There is an increased level of LDL-C children and adolescents with short stature. However, underlying factors associated stature are unknown. In addition, insulin-like growth 1 (IGF-1) short-stature population usually below normal reference range. The aim this study was investigate relationship between IGF-1...
Abstract Background The aims of the present study were to detect serum brain‐derived neurotrophic factor (BDNF) protein concentrations in healthy and diabetic subjects with sleep disorders explore correlations among BDNF concentrations, metabolic parameters inflammation. Methods In all, 377 eligible recruited underwent a 75‐g oral glucose tolerance test. Various clinical cytokines measured. Sleep assessed using Pittsburgh Quality Index (PSQI). Subjects grouped into those normal (NGT), NGT...
Abstract Background The growth hormone/insulin-like factor-1 (GH/IGF-1) axis is critical for the regulation of children’s and development. Serum IGF-1 concentrations are usually low in individuals with idiopathic short stature (ISS) despite normal endogenous GH levels, associated underlying factors unknown. This study aimed to explore relationship between hemoglobin (Hb) children ISS. Methods A cross-sectional analysis was performed including 178 adolescents ISS who were enrolled from March...
Abstract Blood pressure (BP), especially systolic BP (SBP), is higher in adult growth hormone deficiency (AGHD) patients than normal controls. Additionally, obesity a known risk factor for hypertension, and (GHD) an important cause of short stature. For children with GHD, attention has been directed solely towards height. Few studies have assessed its potential impact on BP. Here, we investigated the effect body mass index standard deviation score (BMISDS) This study included 736 stature...
Delays in skeletal maturity are related to bone mass and fracture risk children, but the factors that determine it unknown. We aimed identify association between insulin-like growth factor-1 (IGF-1) maturation before after hormone (GH) treatment.In this retrospective cohort study, we observed 783 short children adolescents, 229 of whom received GH therapy. Skeletal was assessed based on difference age (BA) chronological (CA) (noted as BA-CA). Anthropometric data laboratory values were...
The aim of this study was to investigate the effect serum calcium and phosphorus levels on insulin-like growth factor 1 (IGF-1) in Chinese children adolescents with short stature.In cross-sectional analysis, clinical data 747 height below -2 SD who were evaluated at Department Endocrinology, Affiliated Hospital Jining Medical University from March 1, 2013, February 28, 2019, selected. Anthropometric biochemical indicators measured. relationship between IGF-1 analysed.The univariate analysis...