A5077740659- Diabetes and associated disorders
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Genetic Associations and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Thyroid Cancer Diagnosis and Treatment
- Diabetes Management and Research
- T-cell and B-cell Immunology
- Diabetes Treatment and Management
- Hormonal Regulation and Hypertension
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- RNA and protein synthesis mechanisms
- NF-κB Signaling Pathways
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Genetics and Neurodevelopmental Disorders
- Chemokine receptors and signaling
- RNA modifications and cancer
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ion channel regulation and function
- Inflammatory Biomarkers in Disease Prognosis
Linyi People's Hospital
2015-2025
Stomatology Hospital
2023
Sun Yat-sen University
2023
Shandong University
2008
Shandong Provincial Hospital
2008
Congenital hypothyroidism (CH), the most common neonatal metabolic disorder, is characterized by impaired neurodevelopment. Although several candidate genes have been associated with CH, comprehensive screening of causative has limited.One hundred ten patients primary CH were recruited in this study. All exons and exon-intron boundaries 21 for analyzed next-generation sequencing. And inheritance pattern was study family pedigrees.Our results showed that 57 (51.82%) carried biallelic...
ABSTRACT Type 2 diabetes (T2D) and hypertension often coexist, insulin resistance (IR) plays an important role in their pathological progression. An increasing number of studies have focused on the relationship between different IR indices hypertension. A natural log transformation glucose disposal rate (log e GDR) has been proposed as a new model for sensitivity patients with T2D. The study aimed to explore GDR T2D patients. This cross‐sectional included 1544 Chinese Clinical biochemical...
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are multipotent stroma which can provide a potential therapy for diabetes mellitus. But the mechanism is still controversial. Also, status of BM-MSCs under hyperglycemia not known. In present study, we investigated in experimental-diabetic rat and demonstrated rescue experimental by diabetic MSCs transplantation.BM-MSCs were cultured multiple-differentiation was identified through induction into osteoblasts. passage 3 used following...
To determine whether genetic heterogeneity exists in patients with Graves' disease (GD), the cytotoxic T-lymphocyte associated 4 (CTLA-4) gene, which is implicated a susceptibility gene for GD by considerable and immunological evidence, was used association analysis Chinese Han cohort recruited from various geographic regions. Our study SNPs CTLA4 2640 2204 control subjects confirmed that population. Moreover, logistic regression combined revealed SNP rs231779 (allele frequencies p =...
Graves' disease (GD) is one of the most common human autoimmune diseases, and recent data estimated a prevalence clinical hyperthyroidism 0.25–1.09% in population. Several reports have linked GD to region 5q12–q33; locus between markers D5s436 D5s434 was specifically susceptibility Chinese In present study, association analysis performed using large number single-nucleotide polymorphisms (SNPs) at this 2811 patients with recruited from different geographic regions China. The strongest...
Glomerular hypertrophy and extracellular matrix accumulation are early features of diabetic nephropathy (DN). High glucose-induced oxidative stress is implicated in the etiology DN. This study aims to investigate effect eleutheroside E (EE) on high glucose mediated rat mesangial cells (MCs) proliferation monocyte chemoattractant protein-1 (MCP-1) expression underlying mechanism. MCs was assessed by MTT assay. Reactive oxygen species (ROS) level MCP-1 were evaluated ELISA kit. The protein...
Thyroid-stimulating hormone (TSH) is a sensitive indicator of thyroid function. High and low TSH levels reflect hypothyroidism hyperthyroidism, respectively. Even within the normal range, small differences in levels, on order 0.5-1.0 mU/l, are associated with significant blood pressure, BMI, dyslipidemia, risk atrial fibrillation atherosclerosis. Most variance thought to be genetically influenced. We conducted genome-wide association study 1346 Chinese Han individuals. In replication study,...
Lung cancer is one of the most common malignancy worldwide and causes estimated 1.6 million deaths each year. Cancer immunosurveillance has been found to play an important role in lung may be related with its prognosis. KLRK1, encoding NKG2D, a homodimeric lectin-like receptor. However, there not research KLRK1 as biomarker cancer. Data including patients` clinical characteristics RNAseq information from TCGA were downloaded. A total 1019 patients included this study, among which 407 female...
To pinpoint the exact location of etiological variant/s present at 1q21.1 harboring FCRL1-5 and CD5L genes, we carried out a refined association study in entire FCRL region 1,536 patients with Graves' disease (GD) 1,516 sex-matched controls by imputation analysis, logistic regression, cis-eQTL analysis. Among 516 SNPs P<0.05 initial GWAS scan, strongest signals associated GD correlated to FCRL3 expression were located cluster including rs7528684 rs3761959. And allele-specific effects for...
Abstract Context Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are the 2 main autoimmune thyroid diseases that have both similarities differences. Determining genetic basis distinguishes HT from GD is key for a better understanding of differences between these closely related diseases. Objects To identify susceptibility genes in Chinese cohort compare HT. Design In current study, 18 SNPs established risk loci were selected then genotyped 2682 patients with HT, 4980 GD, 3892 controls....
Diabet. Med. 27, 1312–1317 (2010) Abstract Aims Lipotoxicity has recently been shown to be an important risk factor underlying the pathogenesis of pre‐diabetes. However, clinical evidence supporting treatment pre‐diabetes by improving lipotoxicity is lacking. Here, we conducted open‐label, randomized, controlled trial investigate whether fenofibrate, widely used hypolipidaemic agent, might benefit pre‐diabetes, with metfomin and diet control, recommended intervention methods, as positive...
In our previous studies, we presumed subtypes of Graves’ disease (GD) may be caused by different major susceptibility genes or variants a single gene. However, more evidence is needed to support this hypothesis. Single-nucleotide polymorphism (SNP) rs2476601 in PTPN22 the loci GD European population. has not been found Asian populations. Here, investigate whether gene for Chinese population and further determine variant GD. We conducted an imputation analysis based on results genome-wide...
The aim of the present study was to determine whether expression levels interleukin (IL)‑2 and IL‑10 may be used as biological markers in Graves' disease (GD) patients. A total 256 individuals, including 118 GD patients 138 healthy were enrolled into study. Blood samples collected from each patient individual, which then subjected enzyme‑linked immunosorbent assay (ELISA). Total RNA proteins determined using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) western blot...
<h3>Importance</h3> Thyrotoxic periodic paralysis (TPP) is a potentially lethal complication of hyperthyroidism. However, only 1 specific susceptibility locus for TPP has been identified. Additional genetic determinants should be detected so that prediction model can constructed. <h3>Objective</h3> To investigate the architecture and distinguish from Graves disease cohorts. <h3>Design, Setting, Participants</h3> This population-based case-control study used 2-stage genome-wide association to...
Convincing evidence has demonstrated the association of TSH receptor (TSHR) with Graves' disease (GD) in Chinese Han population.The aim this study was to identify causal variants for GD region encompassing TSHR by a refining study.GD patients (1536) and 1516 sex-matched controls were recruited first stage, an additional 3832 3426 replication stage. Genotyping performed using Illumina Human660-Quad BeadChips or TaqMan single nucleotide polymorphism (SNP) Assays Fluidigm EP1 platform.When...
As a parameter integrating platelet (P), neutrophil (N), and lymphocyte (L) levels, the systemic immune-inflammation index (SII) has been used as prognostic marker for patient survival in various types of solid malignant tumors. However, there is no in-depth study non-small-cell lung cancer (NSCLC) patients with brain metastases after stereotactic radiotherapy. Therefore, we performed retrospective analysis to determine clinical value SII NSCLC who underwent radiotherapy.We enrolled 124...
The purpose of this study was to evaluate and compare multiple daily injection (MDI) therapy bolus insulin aspart basal glargine with continuous subcutaneous infusion (CSII) in patients type 2 diabetes mellitus (T2DM). It assessed whether MDI capable controlling glycemic index a higher efficacy than CSII by preferential adjustment lower total dosage T2DM. Two hundred T2DM were enrolled the randomly assigned (n=100) (n=100; immediately prior each meal at bedtime) groups for 12 weeks therapy....
Objective To investigate prospectively the insulin dose requirements of Chinese patients with type 2 diabetes mellitus treated either multiple daily injections (MDI) or continuous subcutaneous infusion (CSII) therapy during a 2-week therapeutic intervention. Methods Patients were randomly assigned to MDI CSII therapy. The effects two treatment methods determined based on blood glucose parameters, total and rates hypoglycaemia. Results A 609 enrolled in study. Glycaemic goals achieved after...
Graves' disease (GD) is one of the most common autoimmune thyroid diseases (AITDs) in humans, and thyrotropin receptor antibody (TRAb) a characterized autoantibody GD. The use radioactive iodine therapy (RAI) for GD treatment increasing.We studied biological properties TRAb evaluated effect RAI on patients.In total, 225 patients (22 onset without 131I therapy, 203 treated with therapy) 20 healthy individuals as normal controls were included this study. Clinical assessments performed, we...
To observe the short-term dynamic change in serum CXC chemokine ligand-10 (CXCL10) levels patients with Graves' disease (GD) before and after iodine therapy to analyze relationship between CXCL10 clinical indices.ELISA was used determine of 43 GD shortly radioiodine on days six, 14, 60, post-therapy.Patients newly diagnosed showed significantly higher compared control group (P < 0.01). The level increased slightly day six treatment radioactive There no significant statistical difference...