A5091303181- Estrogen and related hormone effects
- Inflammatory mediators and NSAID effects
- Synthesis and biological activity
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- HIV Research and Treatment
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- MicroRNA in disease regulation
- Monoclonal and Polyclonal Antibodies Research
- Natural product bioactivities and synthesis
- Heat shock proteins research
- HIV/AIDS Research and Interventions
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Plant biochemistry and biosynthesis
- Chemical Synthesis and Analysis
- Axon Guidance and Neuronal Signaling
- Inflammatory Biomarkers in Disease Prognosis
- HIV, Drug Use, Sexual Risk
- Chromatography in Natural Products
- Drug Transport and Resistance Mechanisms
- Ovarian cancer diagnosis and treatment
- HER2/EGFR in Cancer Research
Cleveland State University
2015-2024
Beijing YouAn Hospital
2019-2024
Capital Medical University
2019-2024
Nanchong Central Hospital
2020-2024
Heze Municipal Hospital
2024
North Sichuan Medical University
2020-2024
Tongji University
2010-2023
Shanghai Tenth People's Hospital
2014-2023
Chinese People's Armed Police Force
2016-2023
Chinese People's Armed Police General Hospital
2020-2023
Aims The hedgehog signaling pathway plays an important role in EMT of pancreatic cancer cells, but the precise mechanisms remain elusive. Because S100A4 as a key moleculer marker was found to be upregulated upon Gli1 we focused on relationship between Shh-Gli1 signals and S100 genes family. Methods On base cDNA microarray data, investigated regulating mechanism some members S100A family cell lines firstly. Then, regulation gene studied by molecular biology assays pro-metastasis effection...
With the clinical success of several synthetic aromatase inhibitors (AIs) in treatment postmenopausal estrogen receptor-positive breast cancer, researchers have also been investigating potential natural products as AIs. Natural from terrestrial and marine organisms provide a chemically diverse array compounds not always available through current chemistry techniques. that used traditionally for nutritional or medicinal purposes (e.g., botanical dietary supplements) may afford AIs with...
Twelve xanthone constituents of the botanical dietary supplement mangosteen (the pericarp Garcinia mangostana) were screened using a noncellular, enzyme-based microsomal aromatase inhibition assay. Of these compounds, garcinone D (3), E (5), α-mangostin (8), and γ-mangostin (9) exhibited dose-dependent inhibitory activity. In follow-up cell-based assay SK-BR-3 breast cancer cells that express high levels aromatase, most potent four xanthones was (9). Because may be consumed in substantial...
Abstract Stereotactic body radiotherapy (SBRT) has emerged as a standard treatment for non-small-cell lung cancer. However, its therapeutic advantages are limited with the development of SBRT resistance. The SBRT-resistant cell lines (A549/IR and H1975/IR) were established after exposure hypofractionated irradiation. differential lncRNAs screened by microarray assay, then expression was detected in LUAD tumor tissues qPCR. influence on radiation response assessed via vitro vivo assays,...
Radiation resistance is linked to immune escaping and radiation sensitivity. In this study, we found that the PD-L1 expressions of non-killed tumor cells in NSCLC were enhanced after radiotherapy, dihydroartemisinin (DHA) could synergistically enhance antitumor effect radiotherapy NSCLC. A total 48 patients with sufficient tissues for further analyses enrolled. The evaluated by immunohistochemistry. Cell apoptosis was measured flow cytometry, relationship between expression investigated...
Thyroid-stimulating hormone (TSH) is a sensitive indicator of thyroid function. High and low TSH levels reflect hypothyroidism hyperthyroidism, respectively. Even within the normal range, small differences in levels, on order 0.5-1.0 mU/l, are associated with significant blood pressure, BMI, dyslipidemia, risk atrial fibrillation atherosclerosis. Most variance thought to be genetically influenced. We conducted genome-wide association study 1346 Chinese Han individuals. In replication study,...
Ursolic acid has various pharmacological activities, and can reduce blood fat as well having antihepatic, antitumoral, anti-inflammatory antiviral properties. However, the pro-apoptotic mechanism by which ursolic influences human prostate cancer requires additional study. The aim of present study was to assess whether activates apoptosis investigate Rho-associated protein kinase 1 (ROCK1)/phosphatase tensin homolog (PTEN) signaling pathway performs a role in acid-mediated cofilin-1 induce...
Heat shock protein 27 (Hsp27) is a chaperone protein, and its expression increased in response to various stress stimuli including anticancer chemotherapy, which allows the cells survive causes drug resistance. We previously identified lead compounds that bound Hsp27 tubulin via proteomic approaches. Systematic ligand based optimization current study significantly cell growth inhibition apoptosis inducing activities of compounds. Compared compounds, one new derivatives exhibited much better...
Osteosarcoma is an aggressive bone tumor with high resistance to radiotherapy. Pleckstrin homology-like domain family A member 2 (PHLDA2) displays low expression in human osteosarcoma as a proapoptosis factor. miRNAs have been shown be important modulating translation and therapeutic responsiveness solid tumors. Herein, we used luciferase assay show that miR-214 downregulates the PHLDA2 by targeting its 3'-untranslated region (UTR). level of was identified tissues from 30 patients via qPCR...
The cascaded, bio-responsively delivered eNOS gene and ZNF<sub>580</sub> overcome transfection bottlenecks collaboratively exert anti-ischemic function <italic>via</italic> promoting angiogenesis alleviating inflammation.
Aromatase is a particularly attractive target in the treatment of estrogen receptor positive breast cancer. levels cancer cells are enhanced by prostaglandins and reduced COX inhibitors. The synthesis biological evaluation novel series sulfonanilide analogues derived from COX-2 selective inhibitor NS-398 described. compounds suppress aromatase enzyme activity SK-BR-3 dose- time-dependent manner. effect these on inhibition investigated as well. Structure−activity analysis does not find...