A5100641834- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Metabolism, Diabetes, and Cancer
- Diabetes Treatment and Management
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- Extracellular vesicles in disease
- interferon and immune responses
- Cardiac tumors and thrombi
- Cancer-related Molecular Pathways
- Diabetes and associated disorders
- Radiopharmaceutical Chemistry and Applications
- CNS Lymphoma Diagnosis and Treatment
- Advanced Electron Microscopy Techniques and Applications
- Inflammation biomarkers and pathways
- Image Processing Techniques and Applications
- Medicinal Plant Pharmacodynamics Research
- Signaling Pathways in Disease
- Diet, Metabolism, and Disease
- Vascular Malformations Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Phagocytosis and Immune Regulation
- Cell death mechanisms and regulation
Shandong Provincial Hospital
2009-2023
Shandong First Medical University
2020-2023
Second Affiliated Hospital of Nanchang University
2022
Nanchang University
2022
Shandong University
2008-2020
Molecular Innovations (United States)
2018
Cornell University
2018
Weill Cornell Medicine
2018
Zhengzhou University
2010
Sichuan University
2004
Growing studies have focused on the role of microRNA-21 (miR-21) in glioma, thus our objective was to discuss effect M2 bone marrow-derived macrophage (BMDM)-derived exosomes (BMDM-Exos) shuffle miR-21 biological functions glioma cells by regulating paternally expressed gene 3 (PEG3).Seventy-one cases human tissues and 30 non-tumor normal brain were collected stored liquid nitrogen. PEG3 expression tested. The fasting venous blood patients healthy control centrifuged, then supernatant at -...
Tumor derived small extracellular vesicles (TsEVs) display a great potential as efficient nanocarriers for chemotherapy because of their intrinsic targeting ability. However, the inherited risks original cargos (like loaded proteins or RNAs) from parent cancer cells in tumor progression severely hinder practical application. In this study, saponin-mediated cargo elimination strategy was established and practiced glioblastoma (GBM) cell-derived (GBM-sEVs). A high eliminating efficacy...
Both peroxisome proliferator-activated receptor-α (PPARα) and pancreatic/duodenal homeobox-1 (PDX-1) have been reported to be associated with glucose-stimulated insulin secretion (GSIS), but the relationship between PPARα PDX-1 is not yet fully understood. In present study, we tested hypothesis that regulates expression of in β-cells. Isolated pancreatic islets from Wistar rats rat insulinoma (INS-1) β-cells were cultured media supplemented without 0.2 or 0.4 mm palmitate, treated a agonist...
Histone deacetylase (HDAC) inhibition is becoming an increasingly popular approach to treat cancer, as HDAC overexpression common in many malignancies. The blood–brain barrier (BBB) prevents systemically delivered drugs from reaching brain at effective concentration, making small-molecule-HDAC tumors particularly challenging. To circumvent the BBB, novel routes for administering therapeutics are being considered clinic, and a need exists whose deliveries can be directly imaged, so that...
Abstract The effect of leucine on glucose‐stimulated insulin secretion (GSIS) in pancreatic β‐cells is quite controversial, and mechanism involved the has not been elucidated yet. Consequently, we aimed to investigate GSIS its focusing contribution AMP‐activated protein kinase (AMPK) pancreatic/duodenal homeobox‐1 (PDX‐1). Rat insulinoma (INS‐1, RIN m5F, DN‐PDX‐1#28 PDX‐1#6) were cultured with or without leucine, AICAR (AMPK agonist) compound C antagonist) for 48 hrs. In contrast control,...
Several in vitro studies have revealed the neurotoxicity of 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo). However, underlying mechanism has not been completely elucidated, particularly vivo. This study was designed to TaClo vivo by stereotactically injecting into striatum Wistar rats. After injections, rats were subjected an open field test, and their distance travelled tracks showed decreasing trends over time. The results liquid chromatography-mass spectrometry analysis that...
Abstract Ventriculoperitoneal shunt (VPS) placement is the standard procedure in management of hydrocephalus. The introduction laparoscopy allows better visualization during operation and a more reliable peritoneal terminal catheter, which significantly decreases postoperative obstruction malposition rates. However, fixation methods catheter have not been previously discussed. indications, techniques, complications were compared between conventional VPS laparoscopy-guided VPS. Furthermore,...
Our website uses cookies to enhance your experience. By continuing use our site, or clicking "Continue," you are agreeing Cookie Policy | Continue