A5102894982- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Advanced Combustion Engine Technologies
- Rocket and propulsion systems research
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- Combustion and flame dynamics
- Immune cells in cancer
- Heat transfer and supercritical fluids
- Biodiesel Production and Applications
- Circular RNAs in diseases
- Sports injuries and prevention
- Tendon Structure and Treatment
- Reproductive Biology and Fertility
- Quantum Dots Synthesis And Properties
- Catalytic Processes in Materials Science
- Dendrimers and Hyperbranched Polymers
- Mesenchymal stem cell research
- Evaluation and Optimization Models
- Xenotransplantation and immune response
- Energetic Materials and Combustion
- Cardiac and Coronary Surgery Techniques
- Hemostasis and retained surgical items
- NF-κB Signaling Pathways
- Hydraulic and Pneumatic Systems
Jilin University
2005-2025
Shanghai Jiao Tong University
2020-2024
Shanghai Sixth People's Hospital
2020-2024
Harbin Institute of Technology
2024
Nanjing University
2024
Soochow University
2019
Stem cell derived small extracellular vesicles (sEVs) have been proved to promote neurological recovery after stroke. Recent studies demonstrate a phenomenal tissue repair ability in embryonic stem sEVs (ESC-sEVs). However, whether ESC-sEVs could protect against ischemic stroke remains unknown. Immune responses play an essential role the pathogenesis of stroke, and modulating post-stroke immune ameliorates ischemia-induced brain damage. In this study, we aim determine therapeutic function...
Premature ovarian failure (POF) has a great impact on reproductive endocrine function in females, and it is an important cause of infertility. Previous studies have demonstrated that small extracellular vesicles (sEVs) derived from stem cells play role tissue regeneration. This study aimed to investigate the therapeutic effect sEVs embryonic (ESCs-sEVs) damaged ovaries explore underlying molecular mechanisms.Mice POF models were established by injecting mice with cyclophosphamide busulfan....
Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) possess a great therapeutical potential for osteoarthritis (OA) treatment. However, the steric and electrostatic hindrance of cartilage matrix leads to very limited distribution MSC-sEVs in low bioavailability after intra-articular injection. To overcome this, strategy reverse surface charge by modifying with novel cationic amphiphilic macromolecule namely ε-polylysine-polyethylene-distearyl phosphatidylethanolamine (PPD)...
Blood-brain barrier (BBB) breakdown after ischemic stroke exacerbates brain injury and BBB senescence can cause severe neurological deficits in aged population. Recent evidence reveals that inducible pluripotent stem cell-derived small extracellular vesicles (iPSC-sEVs) possess phenomenal antisenescence capability. However, whether iPSC-sEVs rejuvenate to improve outcomes mice remains unknown. Here, we showed long-term treatment with alleviated aging-induced mice. In mice, significantly...
Tissue-resident stem cell senescence leads to exhaustion, which is a major cause of physiological and pathological ageing. Stem cell-derived extracellular vesicles (SC-EVs) have been reported in preclinical studies possess therapeutic potential for diverse diseases. However, whether SC-EVs can rejuvenate senescent tissue cells prevent age-related disorders still remains unknown. Here, we show that chronic application human embryonic small (hESC-sEVs) rescues the function bone marrow...
The polarization of microglia plays an important role in the outcome ischemic stroke (IS). In aged population, senescent show a predominant pro-inflammatory phenotype, which leads to worse outcomes compared young stroke. Recent research demonstrated that inducible pluripotent stem cell-derived small extracellular vesicles (iPSC-sEVs) possess significant anti-ageing ability. We hypothesized iPSC-sEVs could alleviate senescence regulate this study, we showed treatment with significantly...
Abstract Vascular dementia (VD) is one of the most common types dementia, however, intrinsic mechanism unclear and there still lack effective medications. In this study, VD rats exhibit a progressive cognitive impairment, as well time‐related increasing in hippocampal neural stem cells (H‐NSCs) senescence, lost neurogenesis decline. Then, embryonic cell‐derived small extracellular vesicles (ESC‐sEVs) are intravenously injected into rats. ESC‐sEVs treatment significantly alleviates H‐NSCs...
Aim: This study aimed to explore the effect of small extracellular vesicles from induced pluripotent stem cell-derived mesenchymal cells (iMSC-sEVs) on acute pain and investigate underlying mechanisms. Materials & methods: The pathology tendons was accessed by hematoxylin eosin staining, immunohistochemical immunofluorescent staining. degree measured pain-related behaviors. In vitro, we performed β-hexosaminidase release assay, RT-qPCR, toluidine blue ELISA RNA sequencing. Results: iMSC-sEVs...
Tumor derived small extracellular vesicles (TsEVs) display a great potential as efficient nanocarriers for chemotherapy because of their intrinsic targeting ability. However, the inherited risks original cargos (like loaded proteins or RNAs) from parent cancer cells in tumor progression severely hinder practical application. In this study, saponin-mediated cargo elimination strategy was established and practiced glioblastoma (GBM) cell-derived (GBM-sEVs). A high eliminating efficacy...
Lanthanide (Ln
Abstract Pluripotent stem cell‐derived small extracellular vesicles (PSC‐sEVs) have demonstrated great clinical translational potential in multiple aging‐related degenerative diseases. Characterizing the PSC‐sEVs is crucial for their applications. However, specific marker pattern of remains unknown. Here, sEVs derived from two typical types PSCs including induced pluripotent cells (iPSC‐sEVs) and embryonic (ESC‐sEVs) were analysed using proteomic analysis by liquid chromatography with tandem...
Abstract Osteosarcoma (OS) derived small extracellular vesicles (OS-sEVs) have been shown to induce the formation of cancer-associated fibroblasts (CAFs), characterized by elevated pro-inflammatory factor expression and enhanced migratory contractile abilities. These CAFs play a crucial role in priming lung metastasis orchestrating pre-metastatic niche (PMN) lung. Disrupting communication between OS-sEVs (LFs) emerges as potent strategy hinder OS pulmonary metastasis. Our previously...
Nitro-oleic acid (OA-NO2), acting as anti-inflammatory signaling mediators, are involved in multiple pathways. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is well known a cardiovascular risk biomarker. Our results showed that OA-NO2 downregulated the expression of Lp-PLA2 time- and dose-dependent manner, whereas native OA had no such effect. Furthermore, could repress peripheral blood mononuclear cells apo CIII-transgenic (apo CIII TG) pigs, which exhibited higher activity than did...
Abstract Background Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is an intractable nonbacterial inflammatory disease. Mesenchymal stem cells (MSCs) derived from human induced pluripotent (hiPSCs, iMSCs) have been well documented for the management of and autoimmune disorders because their powerful immunoregulatory anti-inflammatory capacities. Recently, studies indicated that extracellular vesicles (EVs) released iMSCs hold biological functions similar to parental cells. This...
Abstract Chemotherapy is an important therapeutic approach for malignant tumors it triggers apoptosis of cancer cells. However, chemotherapy also induces senescence stromal cells in the tumor microenvironment to promote progression. Strategies aimed at killing while simultaneously eliminating senescent represent effective treatment. Here, we developed engineered Src-siRNA delivery system based on small extracellular vesicles (sEVs) eliminate and therapy. The DSPE-PEG-modified urokinase...