A5037891818- Navier-Stokes equation solutions
- Computational Fluid Dynamics and Aerodynamics
- Advanced Mathematical Physics Problems
- Cancer-related molecular mechanisms research
- Stability and Controllability of Differential Equations
- Wastewater Treatment and Nitrogen Removal
- Gas Dynamics and Kinetic Theory
- Glioma Diagnosis and Treatment
- Fluid Dynamics and Turbulent Flows
- Membrane Separation Technologies
- Viral Infections and Immunology Research
- RNA Research and Splicing
- Gut microbiota and health
- Advanced Mathematical Modeling in Engineering
- Traffic control and management
- Viral gastroenteritis research and epidemiology
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Aquaculture Nutrition and Growth
- RNA modifications and cancer
- Stochastic processes and financial applications
- Transportation Planning and Optimization
- Heterotopic Ossification and Related Conditions
- Cancer Mechanisms and Therapy
- interferon and immune responses
Songjiang District Central Hospital
2025
Georgetown University
2009-2024
Inner Mongolia University
2021-2024
Second Affiliated Hospital of Jilin University
2012-2024
Ningbo University
2024
Anhui Medical University
2020-2024
Shandong Provincial Hospital
2013-2023
Renmin University of China
2011-2023
Beijing Polytechnic
2015-2023
Shandong First Medical University
2021-2023
Objective Effects of the diet-induced gut microbiota dysbiosis reach far beyond gut. We aim to uncover direct evidence involving gut–testis axis in aetiology impaired spermatogenesis. Design An excessive-energy metabolic syndrome (MetS) sheep model was established. The testicular samples, host metabolomes and microbiome were analysed. Faecal transplantation (FMT) confirmed linkage between Results demonstrated that number arrested spermatogonia markedly elevated by using 10× single-cell...
Growing studies have focused on the role of microRNA-21 (miR-21) in glioma, thus our objective was to discuss effect M2 bone marrow-derived macrophage (BMDM)-derived exosomes (BMDM-Exos) shuffle miR-21 biological functions glioma cells by regulating paternally expressed gene 3 (PEG3).Seventy-one cases human tissues and 30 non-tumor normal brain were collected stored liquid nitrogen. PEG3 expression tested. The fasting venous blood patients healthy control centrifuged, then supernatant at -...
It has been proven that maternally expressed 3 (MEG3), a long non-coding RNA (LncRNA), is down-regulated and inversely correlated with prognosis in various types of cancer, including bladder cancer (BC). Nevertheless, the role MEG3 BC not fully identified. Herein, we found expression was reduced 21 tumor tissue samples compared to corresponding adjacent tissues. We then established T24 5637 cells stably integrated by G418 resistance screening, data revealed over-expressing displayed weaker...
Coxsackievirus A16 (CA16) is a member of the Picornaviridae family and causes mild self-limiting hand, foot, mouth disease (HFMD) in infants young children. CA16 infection can also progress to central nervous system (CNS) complications; however, underlying mechanism by which penetrates blood-brain barrier (BBB) then CNS damage remains unclear. This study aimed explore neurotropic tropism establishing an vitro BBB model with vivo rhesus monkey infant model. The results showed that induced...
Activated sludge processes with an ultra-short retention time (ultra-short-SRT) are considered to have potential for energy and resource recovery from wastewater. The present study focused on the characteristics, system performance microbial kinetics in ultra-short-SRT activated (USSAS) using typical domestic wastewater (SRT = 0.5, 1, 2, 3 4 d). results showed that compared conventional (CAS) processes, structure USSAS was looser (fractal dimension, D2P, 1.19–1.33), boundary rougher (pore...
The gas filter system exploits the properties of noble gases, which are characterised by minimal absorption below their ionisation thresholds and enhanced above these thresholds. This allows high harmonics incident beam in synchrotron radiation beamline to be absorbed. article is a differential pumping that achieves pressure difference across several orders magnitude with tubes vacuum pumps. Co-existence multiple flow regimes makes it difficult calculate internal distribution through...
Recently, we showed that intratumoral delivery of low-dose, immunostimulatory CpG oligodeoxynucleotides conjugated with carbon nanotubes (CNT-CpG) was more effective than free and not only eradicated intracranial (i.c.) gliomas but also induced antitumor immunity protected mice from subsequent i.c. or systemic tumor rechallenge. Here, examined whether the same "intracerebral immunotherapy" strategy could be applied to treatment metastatic brain tumors.Mice both s.c. melanomas were injected...
Glioma is one of the leading causes death worldwide with high incidence, recurrence, and mortality. Interleukin-10 (IL-10) a cytokine dual function in many types tumors. Although IL-10 overexpressed promotes tumor progression human primary brain tumor, mechanisms are largely unknown.Glioma cells were treated different dosages IL-10. The cell growth was detected by CCK-8, invasion measured Transwell. relative expression messenger RNAs quantitative real-time polymerase chain reaction.We found...
As the global population ages, searching for drugs and functional foods which can slow down aging process has attracted a number of researchers. In this paper, Lycium barbarum polysaccharides (LBP) extracted from was characterized effects LBP on health C. elegans were studied. Results showed that prolong lifespan, improve abilities to withstand environmental stress, enhance reproductive potentials, maintain muscle integrity elegans. By using genetically mutated strains, RNAi gene silencing,...
IoT devices usually operate in random-sparse-event scenarios (Fig. 20.2.1). To avoid missing events, traditionally a periodic-wake-up frequency [1] must be orders of magnitude higher than the average event rate, wasting huge power. An emerging event-driven approach seeks to trigger power-hungry high-performance system (HPS) using an ultra-low-power wake-up circuit. State-of-the-art chips with DSP-based and neural-network-based feature extraction consume 12nW [2], 1μW [3], 142nW [4]. However,...
Power is a major bottleneck in AIoT devices, which usually operate random-sparse-event (RSE) scenarios [1] (Fig. 12.1.1, bottom). To process RSEs energy-efficiently, one can integrate an always-on wake-up chip [1-5] that only turns on the power-hungry high-performance system (HPS) once valid events are detected. Previous dedicated voice-activity-detection (VAD) chips using analog front-ends (AFE) followed by neural-network (NN) circuits consume 1μW [2] and 142nW [3]. Keyword spotting (KWS)...
Abstract The molecule mechanisms of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in human diseases have been broadly studied recently, therefore, our research aimed to assess the effect lncRNA taurine upregulated gene 1 (TUG1)/miR-187-3p/tescalcin (TESC) axis pituitary adenoma (PA) by regulating nuclear factor-kappa B (NF-κB) signaling pathway. We observed that TUG1 was PA tissues associated with invasion, knosp grade tumor size. particularly bound miR-187-3p. knockdown inhibited...
This article presents a 148-nW always-on wake-up system that drastically reduces the power consumption of Internet Things (IoT) sensor nodes while oftentimes operating in random-sparse-event (RSE) scenarios. To significantly reduce long-term average (LTA) and realize multiapplication intelligent event detection, three techniques are proposed: 1) In three-stage pipelined event-driven architecture, frame generator convolutional neural network inference engine (CNN IIE) stage III by preliminary...
Men with prediabetes often exhibit concomitant low-quality sperm production or even infertility, problems which urgently require improved therapeutic options. In this study, we have established a sheep model of diet-induced that is associated spermatogenic defects and explored the possible underlying metabolic causes.We compared male fed normal diet those in was induced by rich third group supplemented melatonin. Only had symptoms prediabetes, these sheep, found impaired spermatogenesis...
Controlled mRNA storage and stability is essential for oocyte meiosis early embryonic development. However, how to regulate in mammalian oogenesis remains elusive. Here we showed that LSM14B, a component of membraneless compartments including P-body-like granules mitochondria-associated ribonucleoprotein domain (MARDO) germ cell, indispensable female fertility. To reveal loss LSM14B disrupted primordial follicle assembly caused reduction non-growing oocytes, which was concomitant with the...
Data from EV-D68-infected patients demonstrate that pathological changes in the lower respiratory tract are principally characterized by severe illness children and acute flaccid myelitis. However, lack of a suitable animal model for EV-D68 infection has limited study on pathogenesis this critical pathogen, development vaccine. Ferrets have been widely used to evaluate virus infections. In current study, we ferrets as potential identify impersonal indices, involving clinical features...
Platelet-derived growth factor-bb (PDGF-BB) is a potent chemokine and mitogen for fibroblasts, keratinocytes, vascular endothelium in the injured area, believed to be effective wound healing. However, short half-life of PDGF-BB its rapid release from surface limited efficacy vivo vitro. To evaluate healing effects dorsal skin SD rats with polydopamine-assisted immobilized on PLGA nanofibrous substrate. First, pDA-coating immobilization morphology, compositions, hydrophilicity substrates were...