A5013902395- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Glycation End Products research
- Glioma Diagnosis and Treatment
- Piperaceae Chemical and Biological Studies
- S100 Proteins and Annexins
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Immunotherapy and Immune Responses
- Cancer therapeutics and mechanisms
- Ear Surgery and Otitis Media
- Neurogenesis and neuroplasticity mechanisms
- Heat shock proteins research
- Computational Drug Discovery Methods
- Endoplasmic Reticulum Stress and Disease
- Meningioma and schwannoma management
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Cancer Cells and Metastasis
- Essential Oils and Antimicrobial Activity
- Ginger and Zingiberaceae research
- Alzheimer's disease research and treatments
- Plant Toxicity and Pharmacological Properties
- Cellular Mechanics and Interactions
- Natural product bioactivities and synthesis
Instituto de Saúde
2020-2024
Universidade Federal Fluminense
2020-2024
Instituto Estadual do Cérebro Paulo Niemeyer
2023-2024
Universidade Federal do Rio de Janeiro
2009-2020
Universidade de São Paulo
2015-2016
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2014
Recent studies indicate that the cell membrane, interacting with its attached cytoskeleton, is an important regulator of function, exerting and responding to forces. We investigate this relationship by looking for connections between membrane elastic properties, especially surface tension bending modulus, function. Those properties are measured pulling tethers from optical tweezers. Their values determined all major types central nervous system, as well macrophage. Astrocytes glioblastoma...
Interaction of RAGE (the receptor for advanced glycation endproducts) with its ligands can promote tumor progression, invasion, and angiogenesis. Although blocking signaling has been proposed as a potential anticancer strategy, functional contributions expression in the microenvironment (TME) have not investigated detail. Here, we evaluated effect genetic depletion TME on growth gliomas. In both invasive noninvasive glioma models, animal survival was prolonged knockout (Ager(-/-)) mice....
Oculoleptomeningeal amyloidosis (OA) is a fatal and untreatable hereditary disease characterized by the accumulation of transthyretin (TTR) amyloid within central nervous system. The mechanisms underlying pathogenesis OA, in particular how triggers neuronal damage, are still unknown. Here, we show that fibrils formed mutant form TTR, A25T, activate microglia, leading to secretion tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) nitric oxide. Further, found A25T induce activation Akt,...
Liquid biopsy is a non-invasive method used to detect cancer and monitor treatment responses by analyzing blood or other bodily fluids for biomarkers. Meningiomas are the most common primary central nervous system tumors, biomarkers play crucial role in their diagnosis, prognosis, monitoring. The World Health Organization (WHO) classifies meningiomas based on tumor grades molecular alterations genes such as NF2, AKT1, TRAF7, SMO, PIK3CA, KLF4, SMARCE1, BAP1, H3K27me3, TERT promoter,...
Background: Oral squamous cell carcinoma (OSCC) represents the primary form of oral cancer, posing a significant global health threat. The existing chemotherapy options are accompanied by notable side effects impacting patient treatment adherence. Consequently, exploration and development novel substances with enhanced anticancer fewer have become pivotal in realms biological chemical science. Objective: This work presents pioneering examples naphthoquinone-coumarin hybrids as new category...
Homocysteine (Hcy) is an excitatory amino acid which markedly enhances the vulnerability of neuronal cells to excitotoxicity and oxidative injury. Patients with severe hyperhomocysteinemia exhibit a wide range clinical manifestations including neurological abnormalities such as mental retardation, cerebral atrophy, seizures. In this study we treated cortical astrocytes neurons in culture 10 100 μM Hcy after 24 h exposure cytoskeletal remodeling was analyzed by immunocytochemistry. We...
The tumor microenvironment has a dynamic and usually cancer-promoting function during all tumorigenic steps. Glioblastoma (GBM) is fatal of the central nervous system, in which substantial number non-tumoral infiltrated cells can be found. Astrocytes neighboring these have particular reactive phenotype enhance GBM malignancy by inducing aberrant cell proliferation invasion. suppressor p53 potential non-cell autonomous modulating expression secreted proteins that influence neighbor cells. In...
Glioblastoma (GBM) is the most common primary brain tumor and aggressive glial tumor. This highly heterogeneous, angiogenic, insensitive to radio- chemotherapy. Here we have investigated progression of GBM produced by injection human cells into parenchyma immunocompetent mice. Xenotransplanted animals were submitted magnetic resonance imaging (MRI) histopathological analyses. Our data show that two weeks after injection, presents characteristics recommended World Health Organization for...
Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignancy. Research on essential oils (EOs) has shown important cytotoxic anti-tumor properties, among others. Piperaceae species are rich in EOs here we highlight Piper rivinoides Kunth. We investigated crude from P. rivinoides, their pure major constituents an enriched fraction with main EO compounds (EF) as selective OSCC agents. presented (-)-α-pinene, (-)-β-pinene limonene. showed IC50 lower than all isolated...
Oral squamous cell carcinoma (OSCC) is a worldwide public health problem, accounting for approximately 90% of all oral cancers, and the eighth most common cancer in men. Cisplatin carboplatin are main chemotherapy drugs used clinic. However, addition to their serious side effects, such as damage nervous system kidneys, there also drug resistance. Thus, development new becomes great importance. Naphthoquinones have been described with antitumor activity. Some them found nature, but semi...
Oral squamous cell carcinoma (OSCC) is a global public health problem with high incidence and mortality. The chemotherapeutic agents used in the clinic, alone or combination, usually lead to important side effects. Thus, discovery development of new antineoplastic drugs are essential improve disease prognosis reduce toxicity. In present study, acridine-core naphthoquinone compounds were synthesized evaluated for their antitumor activity OSCC cells. mechanism action, pharmacokinetics,...