A5087933949- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Natural product bioactivities and synthesis
- Biochemical and Molecular Research
- Phytochemistry and Biological Activities
- Plant biochemistry and biosynthesis
- Essential Oils and Antimicrobial Activity
- Traditional and Medicinal Uses of Annonaceae
- Enzyme Catalysis and Immobilization
- Synthesis and Biological Evaluation
- Natural Antidiabetic Agents Studies
- Coccidia and coccidiosis research
- Phytochemicals and Antioxidant Activities
- Toxin Mechanisms and Immunotoxins
- Carbohydrate Chemistry and Synthesis
- Antimicrobial Peptides and Activities
- Analytical Chemistry and Chromatography
- Molecular spectroscopy and chirality
- NMR spectroscopy and applications
- Lipid Membrane Structure and Behavior
- Crystallization and Solubility Studies
- Bee Products Chemical Analysis
- Cholinesterase and Neurodegenerative Diseases
- Enzyme Production and Characterization
- Phytochemistry Medicinal Plant Applications
Universidade Federal do Rio de Janeiro
2016-2025
Universidade do Estado do Rio de Janeiro
2019-2020
Rede de Química e Tecnologia
2017-2020
Centro de Estudos em Psicologia da Saúde
2016-2019
University of California, Riverside
2017-2019
Weatherford College
2017
Military Institute of Engineering
1995-2009
National Institute of Allergy and Infectious Diseases
2006
Ocimum gratissimum L. is popularly used to treat diabetes mellitus. The hypoglycemic activity of this medicinal species has been confirmed by in vivo studies. present study conducted a chemical investigation leaf decoction (10% p/v) O. monitored assays. Four phenolic substances were identified: l-caftaric acid (1), l-chicoric (2), eugenyl-β-d-glucopyranoside (3) and vicenin-2 (4). acute the fractions Og1-S (300 mg/kg), Og1-A (240 mg/kg) Og1-B (80 was evaluated intraperitoneally normal...
Resveratrol is a polyphenol found in black grapes and red wine has many biological activities. In this study, we evaluated the effect of resveratrol alone association with amphotericin B (AMB) against Leishmania amazonensis. Our results demonstrate that possesses both antipromastigote antiamastigote effects, 50% inhibitory concentrations (IC50s) 27 42 μM, respectively. The AMB showed synergy for L. amazonensis amastigotes, as demonstrated by mean sums fractional index concentration (mean...
Leishmania amazonensis, a cause of cutaneous leishmaniasis in Brazil, is neglected disease with toxic and inconsistently effective treatments. The parasite’s survival depends on managing oxidative stress, making redox-regulating enzymes potential therapeutic targets. Geopropolis, resinous product from native stingless bees, shows promising antiparasitic effects. This study aims to evaluate the anti-L. amazonensis activity geopropolis produced by Melipona bicolor, M. marginara, mondury,...
The infectious agent of transmissible spongiform encephalopathies (TSE) is believed to comprise, at least in part, the prion protein (PrP). Other molecules can modulate conversion normal PrPC into pathological conformer (PrPSc), but identity and mechanisms action key physiological factors remain unclear. PrP bind nucleic acids with relatively high affinity. Here, we report small-angle X-ray scattering (SAXS) nuclear magnetic resonance spectroscopy measurements tight complex an 18 bp DNA...
This work reports the nutritional potential and antiradical activity of cladodes Brazilian Opuntia monacantha Haw. (Cactaceae), as well isolation kaempferol isorhamnetin through activity-guided fractionation from its active MeOH extract. TLC, HPLC-DAD NMR techniques were used to detect identify compounds. The water (91.1%), ash, protein, fibre lipid contents (15.0, 5.4, 18.5 1.4 g/100 g, respectively) shown be quite similar mean values other spp., some widely food forage. antioxidant their...
The fusion peptide EBO(16) (GAAIGLAWIPYFGPAA) comprises the domain of an internal sequence located in envelope glycoprotein (GP2) Ebola virus. This region interacts with cellular membrane host and leads to fusion. To gain insight into mechanism peptide-membrane interaction fusion, insertion was modeled by experiments which tryptophan fluorescence (1)H NMR were monitored presence sodium dodecyl sulfate micelles or detergent-resistant fractions. In SDS micelles, undergoes a random coil-helix...
Trypanosoma cruzi is the causative agent of Chagas' disease. The thiosemicarbazone moiety as a pharmacophore has been described for inhibition essential cysteine protease, cruzipain, this parasite. Our recent study identified an amidinohydrazone containing benzofuroxan hit compound cruzipain with trypanosomicidal activity. Structural modification amidinohydrazone, thio- and semicarbazone motifs, using including benzimidazole 1,3-dioxide system new core scaffolds are described. These changes...
Earthworm metabolism is recognized as a useful tool for monitoring environmental insults and measuring ecotoxicity, yet extensive earthworm metabolic profiling using 1H nuclear magnetic resonance (NMR) spectroscopy has been limited in scope. This study aims to expand the embedded material coelomic fluid, coelomocytes, tissue aid systems toxicology research. Fifty-nine metabolites within Eisenia fetida were identified, with 47 detected 41 54 whole-worm samples extracts. The newly but known...
PW2 (HPLKQYWWRPSI) was selected from phage display libraries through an alternative panning method using living sporozoites of <i>Eimeria acervulina</i> as target. Synthetic shows anticoccidial activity against <i>E. and tenella</i> with very low hemolytic activity. It also displays antifungal but no bacteria. We present the solution structure bound to SDS micelles. In absence interface, is in random coil conformation. micelles, structural calculation that Trp-7 forms hydrophobic core...
Abstract A new steroidal saponin was isolated from the bulbs of Allium ampeloprasum L. var. porrum. On basis chemical evidence, comprehensive spectroscopic analyses, and comparison with known compounds, its structure established as (3 β ,5 α ,6 ,25 R )‐3‐{( O ‐ D ‐glucopyranosyl‐(1→3)‐ ‐glucopyranosyl‐(1→2)‐ ‐[ ‐glucopyranosyl‐(1→3)]‐ ‐glucopyranosyl‐(1→4)‐ ‐galactopyranosyl)oxy}‐6‐hydroxyspirostan‐2‐one ( 1 ). Results present study indicated that exhibited haemolytic activity in vitro...
The genus Ocotea (Lauraceae) is distributed mainly in tropical and subtropical regions. Some species of this as O. puberula quixos have been described the literature, showing antibacterial activity. And macrophylla showed anti-inflammatory activity with inhibition COX-1, COX-2, LOX-5. purpose study was phytochemical investigation plant notata from Restinga Jurubatiba National Park, Macaé, RJ, Brazil, search for antimycobacterial fractions compounds. crude extract evaluated presented<mml:math...
The chemical composition and immunosuppressive potential of the flowers from Kalanchoe pinnata (Crassulaceae) were investigated. We found that aqueous flower extract was more active than leaf in inhibiting murine T cell mitogenesis vitro. Flavonoids isolated identified quantitated based on NMR HPLC-DAD-MS analysis, respectively. Along with quercetin, four quercetin glycosyl conjugates obtained, including 3-O-beta-D-glucuronopyranoside 3-O-beta-D-glucopyranoside, which are described for first...
The aim of this research was to perform a phytochemical study the methanol leaves extract T. guianensis (MET) guided by vasodilatory and antioxidant activities. chemical profile MET ethyl acetate fraction (EA fraction) determined HPLC-UV-MS EA fractionation reverse-phase chromatography. vasorelaxant effects MET, fractions, sub-fractions constituents were assessed on rat aorta pre-contracted with phenylephrine. Antioxidant activity evaluated using DPPH assay. results show that MET-induced...
Nucleoside hydrolases are a strategic target for the development of drugs to treat leishmaniasis, neglected disease that affects 700 thousand one million people annually. The present study aimed identify Leishmania donovani nucleoside hydrolase (LdNH) inhibitors from leaves Ormosia arborea, tree endemic Brazilian ecosystems, through strategy based on 1H NMR analyses and chemometrics. aqueous EtOH extract O. arborea inhibited LdNH activity by 95%. was fractionated in triplicate (13 each step,...