A5086321839- Pain Mechanisms and Treatments
- Traditional and Medicinal Uses of Annonaceae
- Veterinary Pharmacology and Anesthesia
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Antioxidant Activity and Oxidative Stress
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pharmacological Effects of Natural Compounds
- Biochemical effects in animals
- Nitric Oxide and Endothelin Effects
- Aldose Reductase and Taurine
- Piperaceae Chemical and Biological Studies
- Blood Pressure and Hypertension Studies
- Cancer Treatment and Pharmacology
- Pharmacological Effects and Assays
- Eicosanoids and Hypertension Pharmacology
- Hormonal Regulation and Hypertension
- Free Radicals and Antioxidants
- Receptor Mechanisms and Signaling
- Phytochemistry Medicinal Plant Applications
- Business and Management Studies
- Synthesis and Reactivity of Heterocycles
- Hearing Impairment and Communication
- Innovative Teaching Methods
- Adipose Tissue and Metabolism
Universidade Federal do Rio de Janeiro
2010-2024
BACKGROUND: Antidepressant drugs act as potent inhibitors of norepinephrine and/or serotonin reuptake and are widely used with opioids for the treatment chronic pain. The mechanism this increased analgesic action is unclear. We compared antinociceptive effects intrathecal administration morphine that a nonselective (amitriptyline) or selective (maprotiline citalopram) antidepressant drug using thermal withdrawal test in rats. also investigated possible mechanisms involved interactions these...
Several new bioactive compounds of the N-acylhydrazone class were developed from safrole, a Brazilian natural product obtained sassafras oil (Ocotea pretiosa). This work investigated effects on cardiovascular system LASSBio-897, analogue lead compound 3,4-methylenedioxybenzoyl-2-thienylhydrazone named LASSBio-294.Thoracic aorta Wistar-Kyoto (WKY) rats was prepared for isometric tension recording and cGMP content determination. Blood pressure (BP) measured in WKY spontaneously hypertensive...
The aim of this research was to perform a phytochemical study the methanol leaves extract T. guianensis (MET) guided by vasodilatory and antioxidant activities. chemical profile MET ethyl acetate fraction (EA fraction) determined HPLC-UV-MS EA fractionation reverse-phase chromatography. vasorelaxant effects MET, fractions, sub-fractions constituents were assessed on rat aorta pre-contracted with phenylephrine. Antioxidant activity evaluated using DPPH assay. results show that MET-induced...
New substances designed for the treatment of anxiety have previously been synthesized, which resulted in identification four new pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives structurally by using zolpidem as lead compound. Among them, LASSBio-873 was most potent to produce analgesic, sedative and hypnotic effects. Thus, we investigated possible mechanisms involved LASSBio-873-induced sedation, well its effects on different models inflammatory pain. (4 mg/kg) reduced locomotor activity...
1 Brazilian forests show high diversity of medicinal plants and several are used in folk medicine for the treatment hypertension asthma. The aim present study was to investigate effects a methanol extract (ME) Cecropia lyratiloba its flavonoid fraction (FF) on contractility cardiac, vascular tracheal smooth muscles. 2 Twitches rat papillary muscles were obtained with electrical stimulation recorded before after exposure increasing concentrations ME FF. 3 Cardiac depression induced by At 500...
The aim of this study was to perform the isolation and characterization vasodilatory flavonoids from Tapirira guianensis Aubl. (Annacardiaceae) leaves. In context, ethyl acetate fraction (EA fraction) obtained subjected fractionation batches by HSCCC affording: myricetin 3-O-α-L-rhamnopyranoside (myricitrin, 1); quercetin 3-O-(6"-O-galloyl)-β-D-galactopyranoside (2); 3-O-α-L-arabinofuranoside (avicularin, 3); (quercitrin, 4). Myricitrin (1) induced a relaxation 56.07 ± 13.04% at 300 μM (P <...
FUNDAMENTO: O tramadol é um analgésico de ação central cujo mecanismo envolve a ativação receptor opioide. Anteriormente, mostramos que o e seus enantiômeros apresentavam efeito inotrópico negativo sobre músculo papilar no qual (+)-enantiômero era mais potente (-)- (±)-tramadol. OBJETIVO: No presente trabalho, investigamos os efeitos do na corrente cálcio tipo L (I Ca-L). MÉTODOS: Os experimentos foram realizados em miócitos ventriculares isolados ratos Wistar utilizando técnica patch-clamp...
The aim of the present study was to determine effects tramadol on vascular reactivity in aortic rings from Wistar-Kyoto (WKY) rats and spontaneously hypertensive (SHR). Aortic rings, with or without endothelium, were obtained male WKY SHR (15-20 weeks old) prepared for isometric tension recording. precontracted phenylephrine (10 micromol/L) 40 mmol/L KCl then exposed cumulative concentrations (0.1-1 mmol/L). Tramadol produced a concentration-dependent relaxation SHR, which not dependent...
Abstract LASSBio‐985 is a sulfonamide compound designed as simplified structure of nonselective phosphodiesterase type 4 (PDE‐4) inhibitor that promotes vasodilatory activity in vitro. PDE are enzymes responsible for the hydrolysis cyclic adenosine 3′,5′‐ monophosphate and guanosine 3′,5′‐monophosphate. Five different isozymes found vascular smooth muscle (PDE1–PDE5). Aortic rings, with or without endothelium, from male normotensive spontaneously hypertensive rats (SHR) were prepared...
Natural products extracted from plants represent a valuable source of new bioactive substances. Many studies describe the potential plant for treatment cardiovascular diseases. Species <i>Mandevilla</i> genus have been studied their biological activities, mainly as antioxidant, anti-inflammatory, and vasorelaxant. However, phytochemical pharmacological profiles <i>Mandevilla moricandiana</i> not investigated yet. The aim this study was to evaluate vasodilator effect hydroalcoholic extract...
The contamination of coastal areas by petroleum and its derivatives is a relevant issue based on large-scale production consumption. This study presents field laboratory surveys the detoxification enzymes estuarine/coastal catfish Genidens genidens to understand enzymatic responses oil environmental conditions. Field catalase (CAT) glutathione S-tranferase (GST) measurements suggest oxidative stress acting repair mechanisms in fishes, but were not induced diesel as indicated studies. On...
Endothelial dysfunction in obesity plays a key role the development of cardiovascular diseases, and it is characterized by increased vascular tonus oxidative stress. Thus, this study aimed to investigate vasodilatory antioxidant activities Mandevilla moricandiana ethyl acetate fraction subfractions. Vascular effects were investigated on aorta isolated from control monosodium glutamate (MSG) induced-obese Wistar rats, activity was assessed 2,2-diphenyl-1-picrylhydrazyl (DPPH) oxygen radical...
Screener, a board game supplemented with online resources, was introduced and distributed by the Brazilian Society of Pharmacology Experimental Therapeutics to postgraduate programs as an instructional tool for process drug discovery development (DDD). In this study, we provided comprehensive analysis five critical aspects evaluating quality educational games, namely: 1) description intervention; 2) underlying pedagogical theory; 3) identification local gaps; 4) impact on diverse...
Abstract Objectives This work investigated the acute antinociceptive effect of a synthetic chalcone, 4-dimethylamino chalcone (DMAC), as well its effects on vincristine-induced peripheral neuropathy (VIPN) in mice. Methods The inhibitory activity myeloperoxidase was assessed by measuring HOCl formation. Formalin and hot plate tests were used to study DMAC. VIPN induced through administration vincristine sulphate (0.1 mg/kg, i.p., 14 days). Then, DMSO, DMAC (10 or 30 mg/kg; i.p.), pregabalin...
Abstract Several plants from the Brazilian Tropical Forest are used in folk medicine for treatment of hypertension and asthma. In this study, we investigated effects hexanic extracts leaves (HLE) stems (HSE) Piper truncatum on contractility cardiac, vascular tracheal smooth muscles. Twitches cardiac muscles obtained with electrical stimulation were recorded before after exposure to increasing concentrations extracts. HLE HSE respectively reduced significantly amplitude twitches 57.05 ± 11.63...
This study evaluated the analgesic and anti-inflammatory activities of Vitex polygama. Ethyl acetate butanol fractions (10-30 mg/kg), obtained from hydroalcoholic leaf extract, showed an antinociceptive effect in acetic acid-induced abdominal writhing test, formalin test modified hot plate mice, indicating a peripheral action. were effective inhibiting nitric oxide TNF-α production, respectively, RAW 264.7 macrophages. Both mg/kg) acute mice with vincristine-induced neuropathic pain exposed...