A5086013515- Pancreatic function and diabetes
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Aldose Reductase and Taurine
- Bariatric Surgery and Outcomes
- Biochemical Analysis and Sensing Techniques
- Pain Mechanisms and Treatments
- Biochemical effects in animals
- Pesticide and Herbicide Environmental Studies
- Liver Disease Diagnosis and Treatment
- Laser Applications in Dentistry and Medicine
- Diabetes and associated disorders
- Oral microbiology and periodontitis research
- Receptor Mechanisms and Signaling
- Nerve injury and regeneration
- Effects and risks of endocrine disrupting chemicals
- Biotin and Related Studies
- Pesticide Exposure and Toxicity
- Adipokines, Inflammation, and Metabolic Diseases
- Maternal and Neonatal Healthcare
- Ovarian function and disorders
- Bone health and osteoporosis research
Universidade Estadual do Oeste do Paraná
2015-2024
Universidade Estadual do Paraná
2021
Institute of Molecular Biology and Biophysics
2016
Universidade Estadual de Campinas (UNICAMP)
2007-2014
Cambridge University Press
2010
New York University Press
2010
Ulrich Medical (Germany)
2009
Elisa (Finland)
2009
Western University
2007
Universidade Estadual de Maringá
2000-2006
In diet-induced obesity, hypothalamic and systemic inflammatory factors trigger intracellular mechanisms that lead to resistance the main adipostatic hormones, leptin insulin. Tumor necrosis factor-α (TNF-α) is one of produced during this process its mechanistic role as an inducer insulin has been widely investigated. Most TNF-α signals are delivered by TNF receptor 1 (R1); however, played in context obesity-associated inflammation not completely known. Here, we show TNFR1 knock-out (TNFR1...
Abstract Background Taurine (TAU), a naturally occurring sulfur‐containing amino acid, is found at high concentrations in plasma and mammalian tissues regulates osmolarity, ion channel activity, glucose homeostasis. Several reports have shown that physiological TAU levels seem to be important for adequate beta (β)‐cell function insulin action, since low of the been reported pre‐diabetic diabetic states. Methods Glucose tolerance sensitivity were investigated mice supplemented with 2% (w/v)...
Estudos demonstraram que os herbicidas à base de glifosato (HBG)s podem estar relacionados a vários prejuízos morfofuncionais aumentam o risco às doenças crônicas. Neste estudo, buscou-se verificar efeitos da exposição um HBG, sobre parâmetros bioquímicos plasmáticos e morfológicos renais, em camundongos fêmeas submetidas ou não ovariectomia. Para se potenciais ao HBG estão associados concentração hormônios ovarianos, grupo C57Bl/6 adultas foram ovariectomizadas (OVX), as demais...
Pancreatic islets isolated from mice treated neonatally with monosodium L-glutamate (MSG) were used to study insulin secretion.Total acetylcholinesterase (AchE) activity of tissue extract was measured as a cholinergic marker. Obesity recorded in 90-day-old MSG (OM) by Lee index reached 366.40 +/- 1.70, compared control (CM) 324.40 1.10 (p < 0.0001). Glucose 5.6 mM induced secretion 36 5 pg/15 min CM and 86 13 OM 0.001). When glucose raised 16.7 mM, secreted 1,271 215 1,017 112 pg/30 CM. AchE...
The incidence of obesity is increasing rapidly all over the world and results in numerous health detriments, including disruptions reproduction. However, mechanisms by which excess body fat interferes with reproductive functions are still not fully understood. After weaning, female rats were treated a cafeteria diet or chow (control group). Biometric metabolic parameters evaluated adulthood. Reproductive parameters, estradiol, progesterone, LH prolactin during proestrus afternoon, sexual...
Abstract One of the most consumed pesticides in world is glyphosate, active ingredient herbicide ROUNDUP®. Studies demonstrate that glyphosate can act as an endocrine disruptor and exposure to this substance at critical periods developmental period may program fetus induce reproductive damage adulthood. Our hypothesis maternal during pregnancy lactation mice will affect development male organs, impairing fertility adult life. Female 0.5% glyphosate-ROUNDUP® their drinking water...
Taurine (TAU) supplementation increases insulin secretion in response to high glucose concentrations rodent islets. This effect is probably due an increase Ca 2+ handling by the islet cells. Here, we investigated possible involvement of cholinergic/phospholipase C (PLC) and protein kinase (PK) A pathways this process. Adult mice were fed with 2 % TAU drinking water for 30 d. The killed pancreatic islets isolated collagenase method. Islets from TAU-supplemented showed higher presence 8·3 m...
Abstract: There is evidence that the lack of metabolic control obese patients may accelerate periodontitis. The aim this study was to evaluate radiographically effect cafeteria-diet-induced obesity on alveolar bone loss in rats subjected periodontal disease. Twenty male Wistar were randomly divided into four groups: 1) group, 2) and ligature group; 3) cafeteria 4) group. animals evaluated for euthanized, mandible each rat removed perform a radiographic evaluation its diet-induced obesity....
The parasympathetic nervous system is important for β-cell secretion and mass regulation. Here, we characterized involvement of the vagus nerve in pancreatic morphofunctional regulation body nutrient homeostasis 90-day-old monosodium glutamate (MSG)-obese rats. Male newborn Wistar rats received MSG (4 g/kg weight) or saline [control (CTL) group] during first 5 days life. At 30 age, both groups were submitted to sham-surgery (CTL groups) subdiaphragmatic vagotomy (Cvag Mvag groups). presented...
The World Health Organization recommends exclusive breastfeeding until 6 months of age as an important strategy to reduce child morbidity and mortality. Studies have associated early weaning with the development obesity type 2 diabetes in adulthood. In our model, we demonstrated that leads increased insulin secretion adolescent males reduced adult offspring. Early weaned exhibit resistance skeletal muscle. did not change signalling muscle female Taking into account is one primary factors for...
To investigate the effects of sericin extracted from silkworm Bombyx mori cocoon on morphophysiological parameters in mice with obesity induced by high-fat diet.Male C57Bl6 aged 9 weeks were allocated to one two groups - Control and Obese, fed a standard or diet for 10 weeks, respectively. Mice then further subdivided into four seven each, as follows: Control, Control-Sericin, Obese-Sericin. The high fat was given 4 more weeks; (1,000mg/kg body weight) orally Control-Sericin Obese-Sericin...
Insulin resistance during pregnancy is counteracted by enhanced insulin secretion. This condition aggravated obesity, which increases the risk of gestational diabetes. Therefore, pancreatic islet functionality was investigated in control nonpregnant (C) and pregnant (CP), cafeteria diet-fed (Caf), (CafP) obese rats. Isolated islets were used for measurements secretion (RIA), NAD(P)H production (MTS), glucose oxidation ( 14 CO 2 production), intracellular Ca 2+ levels (fura-2 AM), gene...