A5067605220- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Metabolism, Diabetes, and Cancer
- Fibroblast Growth Factor Research
- Birth, Development, and Health
- Pharmacology and Obesity Treatment
- Weed Control and Herbicide Applications
- Natural Antidiabetic Agents Studies
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Kruppel-like factors research
- Reproductive Health and Technologies
- Olfactory and Sensory Function Studies
- Diabetes and associated disorders
- Dietary Effects on Health
- Regulation of Appetite and Obesity
- Nuclear Receptors and Signaling
- Biochemical Analysis and Sensing Techniques
- Nutrition and Health in Aging
- Adipokines, Inflammation, and Metabolic Diseases
- Alzheimer's disease research and treatments
- Diabetes Treatment and Management
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
Universidade Estadual de Campinas (UNICAMP)
2021-2025
Hospital de Clínicas da Unicamp
2025
Universidade Estadual do Oeste do Paraná
2019
Fibroblast growth factor 19 (FGF19) signaling in the brain is associated with body weight loss, reduced food intake, and improved glycemic control obese mice through unclear mechanisms. Here, we investigated effects of central FGF19 administration on peripheral tissues, focusing adipose tissue, its contributions to loss. Using single-cell RNA sequencing adult murine hypothalamus, found that has potential target multiple cell populations, including astrocytes-tanycytes, microglia, neurons,...
Abstract One of the most consumed pesticides in world is glyphosate, active ingredient herbicide ROUNDUP®. Studies demonstrate that glyphosate can act as an endocrine disruptor and exposure to this substance at critical periods developmental period may program fetus induce reproductive damage adulthood. Our hypothesis maternal during pregnancy lactation mice will affect development male organs, impairing fertility adult life. Female 0.5% glyphosate-ROUNDUP® their drinking water...
Hyperinsulinemia is frequently associated with aging and may cause insulin resistance in elderly. Since secretion clearance decline age, hyperinsulinemia seems to be maintained, primarily, due a decrease the clearance. To investigate these effects, 3- 18-month-old male C57BL/6 mice were subjected intraperitoneal glucose tolerance tests (ipGTT ipITT) and, during ipGTT, plasma c-peptide measure evaluate vivo Glucose-stimulated isolated pancreatic islets was also assessed, liver samples...
Abstract Resistance exercise exerts beneficial effects on glycemic control, which could be mediated by exercise-induced humoral factors released in the bloodstream. Here, we used C57Bl/6 healthy mice, submitted to resistance training for 10 weeks. Trained mice presented higher muscle weight and maximum voluntary carrying capacity, combined with reduced body gain fat deposition. improved glucose tolerance glycemia, no alterations insulin sensitivity. In addition, trained displayed insulinemia...
Abstract Aging is associated with glucose metabolism disturbances, such as insulin resistance and hyperinsulinemia, which contribute to the increased prevalence of type 2 diabetes (T2D) its complications in elderly population. In this sense, some bile acids have emerged new therapeutic targets treat TD2, well metabolic disorders. The taurine conjugated acid, tauroursodeoxycholic acid (TUDCA) improves homeostasis T2D, obesity, Alzheimer's disease mice model. However, effects aged not been...
Vertical sleeve gastrectomy (VSG) decreases insulin secretion, endoplasmic reticulum (ER) stress, and inflammation in pancreatic islets from obese mice. In addition, VSG increased fibroblast growth factor (FGF)15 circulating levels mice, as well the expression of FGF receptor 1 ( Fgfr1) its coreceptor β-klotho Klb), both mice INS-1E β-cells treated with serum these Serum operated protects cells dysfunction apoptosis, which was mediated by FGF15/19.
Sleeve gastrectomy (SG) successfully recovers metabolic homeostasis in obese humans and rodents while also resulting the normalization of insulin sensitivity insulinemia. Reduced levels have been attributed to lower secretion increased clearance individuals submitted SG. Insulin degradation mainly occurs liver a process controlled, at least part, by insulin-degrading enzyme (IDE). However, research has yet explore whether IDE expression or activity is altered after SG surgery. In this study,...
Resistance training increases insulin secretion and beta cell function in healthy mice. Here, we explored the effects of resistance on glucose sensing survival by using vitro vivo diabetic models. A pancreatic line (INS-1E), incubated with serum from trained mice, displayed increased secretion, which could be linked expression transporter 2 (GLUT2) glucokinase (GCK). When cells were exposed to pro-inflammatory cytokines (in type 1 diabetes), preserved both GCK expression, reduced proteins...