A5102886030- Pancreatic function and diabetes
- Aldose Reductase and Taurine
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Biochemical effects in animals
- Birth, Development, and Health
- Metabolism, Diabetes, and Cancer
- Bariatric Surgery and Outcomes
- Biochemical Analysis and Sensing Techniques
- Dietary Effects on Health
- Liver Disease Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Pesticide and Herbicide Environmental Studies
- Stress Responses and Cortisol
- Diabetes Management and Research
- Drug Transport and Resistance Mechanisms
- Linguistics and Language Studies
- Diabetes Treatment and Management
- Cannabis and Cannabinoid Research
- Ovarian function and disorders
- Biochemical Acid Research Studies
Universidade Estadual de Ponta Grossa
2020-2025
Universidade Federal do Rio de Janeiro
2011-2020
Universidade Federal do Rio Grande do Sul
2012-2013
Universidade Estadual de Campinas (UNICAMP)
2009-2013
Universidade Estadual de Maringá
2007
The Kallikrein-Kinin System (KKS) has been implicated in several aspects of metabolism, including the regulation glucose homeostasis and adiposity. Kinins des-Arg-kinins are major effectors this system promote their effects by binding to two different receptors, kinin B2 B1 respectively. To understand influence KKS on pathophysiology obesity type 2 diabetes (T2DM), we generated an animal model deficient for both receptor genes leptin (obB1B2KO). Six-month-old obB1B2KO mice showed increased...
Scope Poor nutrition during the perinatal period is associated with an increased risk for metabolic syndrome in adulthood. Taurine (TAU) regulates β‐cell function and glucose homeo‐stasis. Here, we assessed effects of TAU supplementation upon adiposity control malnourished mice fed a high‐fat diet (HFD). Methods results Weaned male C57BL/6J were (14% protein ‐ C) or protein‐restricted (6% R) 6 weeks. Afterwards, received not HFD 8 weeks (CH RH). Half HFDmice supplemented 5% after weaning...
Abstract Background Taurine (TAU), a naturally occurring sulfur‐containing amino acid, is found at high concentrations in plasma and mammalian tissues regulates osmolarity, ion channel activity, glucose homeostasis. Several reports have shown that physiological TAU levels seem to be important for adequate beta (β)‐cell function insulin action, since low of the been reported pre‐diabetic diabetic states. Methods Glucose tolerance sensitivity were investigated mice supplemented with 2% (w/v)...
Insufficient or imbalanced protein can disrupt gut microbiota, potentially compromising barrier function and increasing health risks. Herein, we investigated the effects of restriction on cecal microbiota colon morphofunction in male mice. From 30 to 120 days age, C57Bl/6 mice were fed a control diet [14% protein, (C) group] low-protein [6% protein-restricted (R) group]. At end experimental period, R exhibited typical features undernutrition, such as reduced body weight, hypoalbuminemia,...
Estudos demonstraram que os herbicidas à base de glifosato (HBG)s podem estar relacionados a vários prejuízos morfofuncionais aumentam o risco às doenças crônicas. Neste estudo, buscou-se verificar efeitos da exposição um HBG, sobre parâmetros bioquímicos plasmáticos e morfológicos renais, em camundongos fêmeas submetidas ou não ovariectomia. Para se potenciais ao HBG estão associados concentração hormônios ovarianos, grupo C57Bl/6 adultas foram ovariectomizadas (OVX), as demais...
Abstract One of the most consumed pesticides in world is glyphosate, active ingredient herbicide ROUNDUP®. Studies demonstrate that glyphosate can act as an endocrine disruptor and exposure to this substance at critical periods developmental period may program fetus induce reproductive damage adulthood. Our hypothesis maternal during pregnancy lactation mice will affect development male organs, impairing fertility adult life. Female 0.5% glyphosate-ROUNDUP® their drinking water...
Taurine (TAU) supplementation increases insulin secretion in response to high glucose concentrations rodent islets. This effect is probably due an increase Ca 2+ handling by the islet cells. Here, we investigated possible involvement of cholinergic/phospholipase C (PLC) and protein kinase (PK) A pathways this process. Adult mice were fed with 2 % TAU drinking water for 30 d. The killed pancreatic islets isolated collagenase method. Islets from TAU-supplemented showed higher presence 8·3 m...