A5083514189- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Birth, Development, and Health
- Regulation of Appetite and Obesity
- Diet, Metabolism, and Disease
- Genetics and Physical Performance
- Diabetes Management and Research
- Sports Performance and Training
- Exercise and Physiological Responses
- Aldose Reductase and Taurine
- Metabolism, Diabetes, and Cancer
- Obesity, Physical Activity, Diet
- Dietary Effects on Health
- Burn Injury Management and Outcomes
- Laser Applications in Dentistry and Medicine
- Physical Activity and Health
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Cardiovascular and exercise physiology
- Bee Products Chemical Analysis
- Wound Healing and Treatments
- Marine and Offshore Engineering Studies
- Physical Education and Gymnastics
Universidade Federal de São Paulo
2015-2024
Instituto de Saúde
2018-2024
Petrobras (Brazil)
2024
Fundação de Apoio à Universidade Federal de São Paulo
2021
Universidade Estadual de Campinas (UNICAMP)
2008-2019
Universidade Federal do Rio de Janeiro
2014-2018
Universidade Estadual Paulista (Unesp)
2002-2009
Fundação de Amparo à Pesquisa do Estado de São Paulo
2005
Taurine (TAU) supplementation increases insulin secretion in response to high glucose concentrations rodent islets. This effect is probably due an increase Ca 2+ handling by the islet cells. Here, we investigated possible involvement of cholinergic/phospholipase C (PLC) and protein kinase (PK) A pathways this process. Adult mice were fed with 2 % TAU drinking water for 30 d. The killed pancreatic islets isolated collagenase method. Islets from TAU-supplemented showed higher presence 8·3 m...
Epigenetic regulation is considered the main molecular mechanism underlying developmental origin of health and disease's (DOHAD) hypothesis. Previous studies that have investigated role paternal exercise on metabolic offspring did not control for amount intensity training or possible effects adaptation to produced conflicting results regarding benefits parental next generation. We employed a precisely regulated regimen study transgenerational inheritance improved health.We subjected male...
To evaluate the effect of acute exercise and training at anaerobic threshold (AT) intensity on aerobic conditioning insulin secretion by pancreatic islets, adult male Wistar rats were submitted to lactate minimum test (LMT) for AT determination. Half animals swimming (trained), 1 h/day, 5 days/week during 8 weeks, with an overload equivalent AT. The other half was kept sedentary (sedentary). At end experimental period, oral glucose tolerance another LMT. Then, sacrificed rest or immediately...
The present study investigated the role of swimming training on cerebral metabolism and hippocampus concentrations insulin IGF-1 in diabetic rats. Wistar rats were divided sedentary control (SC), trained (TC), (SD), (TD). Diabetes was induced by Alloxan (35 mg kg(-1) b.w.). Training program consisted 5 days/week, 1 h/day, 8 weeks, supporting a load corresponding to 90% maximal lactate steady state (MLSS). For MLSS determination, submitted three sessions 25-min loads 4, 5, or 6% body wt, with...
The Federal University of São Paulo, Baixada Santista Campus was founded in 2006 with five degree-granting programs physical education, physiotherapy, nutrition, psychology, and occupational therapy. guiding principle behind the programs' educational mission centered on development health care professionals capable working interdisciplinary teams an emphasis holistic patient care. This pedagogical structure required peer-mentoring order to integrate different areas knowledge improve learning...
Objectives: We investigated the influence of leucine supplementation on insulin secretion and some proteins related to in malnourished mice. Methods: Swiss mice (aged 21 days) received isocaloric normo-17% (NP) or 6% low-protein (LP) diet for 120 days. Half NP LP 1.5% drinking water during last 30 days (NPL LPL, respectively). Results: The were hypoinsulinemic compared with group, whereas LPL exhibited increased insulinemia fed state versus mouse islets less responsive 22.2 mM glucose, 100...
Insulin resistance during pregnancy is counteracted by enhanced insulin secretion. This condition aggravated obesity, which increases the risk of gestational diabetes. Therefore, pancreatic islet functionality was investigated in control nonpregnant (C) and pregnant (CP), cafeteria diet-fed (Caf), (CafP) obese rats. Isolated islets were used for measurements secretion (RIA), NAD(P)H production (MTS), glucose oxidation ( 14 CO 2 production), intracellular Ca 2+ levels (fura-2 AM), gene...
Reactive oxygen species (ROS) are involved in many physiological and pathological processes. In the present study, we analysed whether synthetic glucocorticoid dexamethasone induces oxidative stress cultured pancreatic islets effects of on insulin secretion, gene expression, viability can be counteracted by concomitant incubation with N-acetylcysteine (NAC).
Estudos têm demonstrado que o exercício físico regular melhora as condições do diabetes, facilitando a captação periférica da glicose e metabolismo de glicogênio, proteínas, etc. Por outro lado, pouco se conhece sobre os efeitos intenso em diabéticos, principalmente com relação ao sistema imune desses organismos. O presente estudo teve como objetivo verificar um treinamento alta intensidade contagem total diferencial leucócitos ratos diabéticos. Ratos machos jovens Wistar foram distribuídos...
The present study was designed to analyse the effects of aerobic exercise on metabolic alloxan. Male Wistar newborn rats (2 days old) received alloxan (200 mg (kg body weight) −1 ) intraperitoneally (A rats). Vehicle‐injected were used as controls (C At 28 old, some A subjected swimming for 1 h day , 5 week (AT 28, 60 and 90 old animals glucose (GTTo) insulin (ITTsc) tolerance tests. All then killed by decapitation blood tissue evaluations. On 60th day, there a reduction in level during GTTo...
Abstract Background Ninety percent of cases diabetes are the slowly evolving non-insulin-dependent type, or Type 2 diabetes. Lack exercise is regarded as one main causes this disorder. In study we analyzed effects physical on glucose homeostasis in adult rats with type induced by a neonatal injection alloxan. Methods Female Wistar aged 6 days were injected either 250 mg/kg body weight alloxan citrate buffer 0.01 M (controls). After weaning, half animals each group subjected to training...
Longer diagnostic delay in SpA was associated with the presence of any extra-articular manifestation on amdission (a) and younger age at onset (b).
Introduction Endurance training improves peripheral insulin sensitivity in the liver and skeletal muscle, but mechanism for this effect is poorly understood. Recently, it was proposed that clearance plays a major role both glucose homeostasis sensitivity. Therefore, our goal to determine by which endurance how regulates mice. Methods Mice were treadmill-trained 4 weeks at 70–80% of maximal oxygen consumption (VO2 max) 60 min, 5 days week. The tolerance resistance determined using an IPGTT...