A5040280814- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Diabetes Treatment and Management
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Sirtuins and Resveratrol in Medicine
- Circadian rhythm and melatonin
- Peptidase Inhibition and Analysis
- Neuropeptides and Animal Physiology
- Venomous Animal Envenomation and Studies
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Healthcare and Venom Research
- Biochemical effects in animals
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Nicotinic Acetylcholine Receptors Study
Instituto Butantan
2015-2023
Centro Universitário Herminio Ometto de Araras
2010
Here, we investigate the effects of obesity induced by monosodium glutamate (MSG) on cognitive impairment and whether this model induces any alteration in affinity, density, subtypes muscarinic acetylcholine receptors (mAChRs) rat hippocampus. Healthy rats were used as controls, MSG-obese selected via Lee index > 0.300. The MSG-induced hippocampal spatial learning memory processes evaluated using working versions Morris’ water maze task evaluation mAChRs binding assay their...
The lack of a complete assembly the sensitivity subcellular aminopeptidase (AP) activities to insulin in different pathophysiological conditions has hampered view adipocyte metabolic pathways and its implications these conditions. Here we investigated influence on basic AP (APB), neutral puromycin-sensitive (PSA), puromycin-insensitive (APM) high low density microsomal plasma membrane fractions from adipocytes healthy obese rats. Catalytic enzymes were fluorometrically monitoring with or...
The pineal gland synthesizes melatonin exclusively at night, which gives the characteristic of a temporal synchronizer physiological systems. Melatonin is regulator insulin activities centrally and also peripherally its synthesis reduced in diabetes. Since monosodium glutamate (MSG) often used to induce type 2 diabetic metabolic syndrome animal models, purpose this work evaluate potential effects MSG given neonates on different aged male female rats. Wistar rats were subcutaneously injected...
Background: Exenatide (EXE), a prototypical GLP-1R agonist, has been reported as beneficial to the balance of bone turnover in hyperlipidic and hyperglucidic diet-induced obesity rats (DIO). Objective: To identify mediation by insulin (INS), leptin (LEP), osteocalcin (OCN), calcitonin (CT), carboxy-terminal telopeptide type 1 collagen (CTX-1), procollagen amino-terminal propeptide (P1NP) mineral density femur (BMDF) DIO. Methods: 72-75-day-old male had access only (i) food (5.2 kcal/g) 30%...
Background: Exenatide (EXE), a prototypical GLP-1R agonist, is known as glucoregulator, antiobesogenic and antidyslipidemic in hyperlipidic hyperglucidic diet-induced obesity rats (DIO). Objective: To evaluate bone effects of DIO treatment with EXE (DIO-E). Methods: 72-75-day-old male had access only to (i) food (5.2 kcal/g) 30% sucrose solution for drinking (1.2 kcal/mL), or (ii) received normocaloric diet (3 were allowed feed drink water ad libitum. 122-125-day-old 20% overweight selected...