A5051133718- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Infectious Diseases and Tuberculosis
- Bone and Joint Diseases
- Surgical site infection prevention
- Bone fractures and treatments
- Hip and Femur Fractures
- Antibiotics Pharmacokinetics and Efficacy
- Streptococcal Infections and Treatments
- Antibiotic Use and Resistance
- Diabetic Foot Ulcer Assessment and Management
- Hematological disorders and diagnostics
- Antifungal resistance and susceptibility
- Antibiotic Resistance in Bacteria
- HIV/AIDS oral health manifestations
- Fungal Infections and Studies
- Bone health and treatments
- Antimicrobial agents and applications
- Hip disorders and treatments
- Animal health and immunology
- HIV-related health complications and treatments
- Antimicrobial Resistance in Staphylococcus
- Gastrointestinal disorders and treatments
- Syphilis Diagnosis and Treatment
Universidade de São Paulo
2012-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2015-2024
Associação de Assistência à Criança Deficiente
2021
Instituto Nacional de Traumatologia e Ortopedia
2020
Weatherford College
2020
Hospital Universitário Pedro Ernesto
2018
Universidade Federal do Rio Grande do Sul
2018
Universidade Federal do Rio Grande
2018
Faculdade de Ciências Médicas de Minas Gerais
2018
Elabora Consultoria (Brazil)
2017
Our purpose was to compare 2 methods of treatment chronic infection in hip arthroplasties--with or without an antibiotic-loaded cement spacer.In a prospective study, we treated 68 infected arthroplasties with discharging sinuses and bone loss, comparing 30 patients stages the use spacer (control group) 38 vancomycin-loaded (study group). The average follow-up 4 years (2-8.5 years). One patient died unrelated causes months after first-stage surgery excluded from study.The 2-stage controlled...
To evaluate the incidence and microbiological profile of surgical site infections (SSIs) associated with internal fixation fractures to compare differences in SSIs observed among patients closed open fractures.Retrospective study. Analyzed data included information from all who underwent surgery for or January 2005 December 2012 remained outpatients at least one year following surgery. Incidence infection (SSI) was compared between infection, as well polymicrobial related Gram-negative...
In view of the action newer macrolide antibiotics on intracellular protozoa, we have investigated efficacy roxithromycin in treatment cryptosporidiosis 26 patients with AIDS. Cryptosporidiosis was confirmed either by faecal examination for parasites (modified Kinyoun method) or detection parasite biopsy material obtained colonoscopy. Patients received oral (300 mg bd) 4 weeks. Twenty-two completed study. At end study, 15 (68%) were considered to be cured and six (27%) improved, failed one...
Septic arthritis is an infrequent disease although very important due to the possibility of disastrous outcomes if treatment not adequately established. Adequate information concerning epidemiology septic still lacking uncommon nature as well struggle establish a correct case-definition.To epidemiologically characterize population seen at Hospital das Clínicas, University São Paulo with diagnosis between 2006 and 2011.Sixty-one patients diagnosed knee 2011 were retrospectively evaluated. The...
OBJECTIVES: Negative-pressure wound therapy has been widely adopted to reduce the complexity of treating a broad range acute and chronic wounds.However, its cost is high.The objective this study was evaluate following two different methods negative-pressure in terms healing time: low-cost method (a pressure stabilizer device connected hospital wall-vacuum system with gauze-sealed dressing, USP) standard care (vacuum-assisted closure, VAC).METHODS: This randomized, controlled,...
The Brazilian Policy for Comprehensive Care People with Rare Diseases was implemented in 2014; however, national epidemiological data on rare diseases (RDs) are scarce and mainly focused specific disorders. To address this gap, University Hospitals, Reference Services Neonatal Screening, Diseases, all of which public health institutions, established the Network (RARAS) 2020. objective study to perform a comprehensive nationwide investigation individuals RDs Brazil. This retrospective survey...
Excessive group 2 carbapenem use may result in decreased bacterial susceptibility. We evaluated the impact of a stewardship program, restricting imipenem and meropenem use. Ertapenem was mandated for ESBL-producing Enterobacteriaceae infections absence non-fermenting Gram-negative bacilli (GNB) from April 2006 to March 2008. Group carbapenems were restricted against GNB susceptible only suspected unstable patients. Cumulative susceptibility tests done nosocomial pathogens before after...
The immunoglobulin G (IgG) uptake and enterocyte nucleus position in the villous were studied newborn goat kids fed or lyophilized bovine colostrum. Two groups of 15 kids, each received 5% body weight colostrum (GC) (LBC) containing 55 mg/mL at 0, 7 14 h life. Three animals sampled just after birth, receiving no intake, to be used as control. Samples duodenum, medium jejunum ileum collected 18, 36 96 IgG vacuoles not observed duodenum throughout experiment regardless all experimental time...
Avaliar a incidência e o perfil microbiológico das ISC relacionadas procedimentos de fixação fraturas num hospital acadêmico ortopédico terciário em São Paulo, Brasil, comparar as diferenças observadas entre os pacientes com fechadas expostas. Estudo retrospectivo. Foram incluídos na análise dados relativos todos que passaram por procedimento cirúrgico para ou expostas janeiro 2005 dezembro 2012 mantiveram seguimento pelo menos um ano. Foi verificada presença associação tipo fratura,...
OBJECTIVES:To clinically and epidemiologically characterize a population diagnosed with treated for septic arthritis of the knee, to evaluate treatment results analyze differences between patients positive negative culture results, Gram-positive Gram-negative bacterial isolates S. aureusand non-S.aureus-related infections.METHODS: One hundred five knee were included in this study.The clinical epidemiological data evaluated.Statistical analysis was performed compare without an isolated...
Abstract Background Evaluate the effect of bacteria drug resistance profile on success rates debridement, antibiotics and implant retention. Methods All early acute periprosthetic infections in hip knee arthroplasties treated with DAIR at our institution over period from 2011 to 2015 were retrospectively analyzed. The rate was evaluated according type organism identified culture: multidrug-sensitive (MSB), methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant Gram-negative...
We sought to evaluate the indirect impact of ertapenem use for treatment extended-spectrum beta-lactamase-producing Enterobacteriaceae infections in our hospital on susceptibility Pseudomonas aeruginosa imipenem. The was mandated absence nonfermenting gram-negative bacilli 1 year. imipenem restricted. Imipenem consumption decreased 64.5%. Ertapenem 42.57 defined daily doses per 1,000 patient-days. None 18 P. isolates recovered after introduction were imipenem-resistant, compared with 4 20 previous
The number of goblet cells containing neutral and acidic mucins, including sulphomucins sialomucins, was investigated in the small intestine goat kids fed with lyophilized bovine colostrum period passive immunity acquisition. At 0, 7 14 h life, 15 male newborns received 5% body weight (LBC) (GC), both 55 mg/mL IgG. Three additional animals were sampled at birth, without intake. Duodenum, jejunum ileum samples collected 18, 36 96 life. Histological stains, periodic acid-Schiff, 1% alcian blue...
Treatment of orthopedic infections usually requires prolonged antimicrobial therapy, ranging from 14 days up to 6 months. Nowadays, rising levels resistance demands parenteral therapy for many patients. Outpatient (OPAT) is a modality that allows treatment out hospital in these situations. In Brazil, where public universal healthcare system full coverage all citizens, implantation and dissemination OPAT programs would be beneficial patients the system, because it allow better allocation...
Abstract: Increasing bone mineralization abnormalities observed among people living with HIV (PLWHIV) result from various factors relating to the host, virus, and antiretrovirals used. Today, infection is considered be a risk factor for disorders. The test most recommended diagnosing osteoporosis measurement of mineral density by means dual energy X-ray absorptiometry at two sites. Osteoporosis treatment has aims mass improvement fracture control. A combination calcium vitamin D...
Longer diagnostic delay in SpA was associated with the presence of any extra-articular manifestation on amdission (a) and younger age at onset (b).
Enteric histology of newborn goat kids fed lyophilized bovine colostrum (LBC) was studied. At 0, 7, and 14 h life 15 male newborns received 5% body weight (GC), both with 55 mg/ml IgG. Samples duodenum, jejunum, ileum were collected at 18, 36, 96 for analyses villus height, crypt depth, muscle layer thickness, partial volume the absorptive mucosa (Vv), density (Sv), quantification goblet cells. Three animals sampled without intake (0 h). The histomorphometry not different between GC LBC in...
Summary The objective of this study was to investigate the development enteric, hepatic and muscle tissues in goat kids fed with lyophilized bovine colostrum transition period passive immunity early active immunity. At 0, 7 14 h life, 15 male newborns received 5% their body weight colostrum, both 55 mg/ml IgG. Samples duodenum, jejunum, ileum, liver were collected at 18, 36 96 life quantify total protein, DNA RNA contents. In jejunum highest levels protein higher protein/ ratio observed 18...
To describe the clinical and epidemiological characteristics of patients with septic arthritis shoulder or elbow to evaluate prognostic factors for complications during treatment.A retrospective case series was studied treated between 2004 2014. The patients' were collected. orthopedic identified possible evaluated.Twenty-seven analyzed, 17 ten elbow. Median age 46 years (IQR, 24.5; 61). Previous joint disease observed in nine (33%). At least one comorbidity 23 (85%). Staphylococcus aureus...