A5059658420- Pancreatic function and diabetes
- Aldose Reductase and Taurine
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Biochemical Analysis and Sensing Techniques
- Drug Transport and Resistance Mechanisms
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Endoplasmic Reticulum Stress and Disease
- Circadian rhythm and melatonin
- Dietary Effects on Health
- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Dialysis and Renal Disease Management
- Liver Disease Diagnosis and Treatment
- Prenatal Substance Exposure Effects
- Nuclear Receptors and Signaling
- Biomedical Research and Pathophysiology
- Diabetes Management and Research
- Public Health in Brazil
- Diabetes Treatment and Management
Universidade Federal da Integração Latino-Americana
2023-2024
Universidade Estadual de Campinas (UNICAMP)
2012-2022
Universidade Estadual do Oeste do Paraná
2021-2022
Fundação de Amparo à Pesquisa do Estado de São Paulo
2019
Hospital de Clínicas da Unicamp
2019
Universitat de Miguel Hernández d'Elx
2015
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2015
Disruption of insulin secretion and clearance both contribute to obesity-induced hyperinsulinemia, though reduced seems be the main factor. The liver is major site for degradation, a process mainly coordinated by insulin-degrading enzyme (IDE). beneficial effects taurine conjugated bile acid (TUDCA) on as well sensitivity have been recently described. However, possible role TUDCA in had not yet explored. Here, we demonstrated that 15 days treatment with reestablished plasma physiological...
Introduction: The consumption of ultra-processed foods rich in fat has contributed to the global rise obesity and other metabolic disorders, including excess adipose tissue accumulation Non-Alcoholic Fatty Liver Disease (NAFLD). Although physical exercise dietary education are first-line treatments for weight loss, restrictive diets often used accelerate reduction. However, these generally unsustainable long term frequently lead regain. Aims: To evaluate effects replacing a high-fat diet...
Type 1 diabetes (T1D) is characterized by impairment in beta-cell mass and insulin levels, resulting hyperglycemia diabetic complications. Since diagnosis, appropriate control of glycaemia T1D requires administration, which can result side effects, such as hypoglycemia. In this sense, some bile acids have emerged new therapeutic targets to treat T2D, well metabolic diseases. The taurine conjugated acid, tauroursodeoxycholic (TUDCA) reduces the incidence development improves glucose...
The effects of exercise on insulin clearance and IDE expression are not yet fully elucidated. Here, we have explored the effect acute in lean mice. Male Swiss mice were subjected to a single bout speed/angle controlled treadmill for 3-h at approximately 60-70% maximum oxygen consumption. As expected, reduced glycemia insulinemia, increased tolerance. activity AMPK-ACC, but IR-Akt, pathway was liver skeletal muscle trained In an apparent contrast glucose-stimulated secretion isolated islets...
Summary The aim of the present study was to evaluate effects aerobic exercise training on perivascular adipose tissue ( PVAT ) function in thoracic aorta from rats fed a high‐fat diet. Aortic vascular reactivity performed sedentary SD ), trained TR diet ‐ HF and male Wistar absence −) or presence +) . We also measured circulatory concentrations leptin tumour necrosis factor alpha TNF ‐α), as well protein expressions ‐α receptor 1 TNFR 1) inducible nitric oxide synthase iNOS In group, body...
The parasympathetic nervous system is important for β-cell secretion and mass regulation. Here, we characterized involvement of the vagus nerve in pancreatic morphofunctional regulation body nutrient homeostasis 90-day-old monosodium glutamate (MSG)-obese rats. Male newborn Wistar rats received MSG (4 g/kg weight) or saline [control (CTL) group] during first 5 days life. At 30 age, both groups were submitted to sham-surgery (CTL groups) subdiaphragmatic vagotomy (Cvag Mvag groups). presented...
Glucocorticoid (GC) therapies may adversely cause insulin resistance (IR) that lead to a compensatory hyperinsulinemia due hypersecretion. The increased β -cell function is associated with signaling has the protein kinase B (AKT) substrate 160 kDa (AS160) as an important downstream AKT effector. In muscle, both and AMP-activated (AMPK) phosphorylate inactivate AS160, which favors glucose transporter (GLUT)-4 translocation plasma membrane. Whether AS160 phosphorylation modulated in islets...
Human life expectancy is increasing faster lately and, consequently, the number of patients with age-related diseases such as type 2 diabetes (T2D) rising every year. Cases hyperinsulinemia have been extensively reported in elderly subjects and this alteration blood insulin concentration postulated to be a cause resistance, which some cases triggers T2D onset. Thus, it important know underlying mechanisms age-dependent find new strategies prevent subjects. Two processes control...
Abstract Resistance exercise exerts beneficial effects on glycemic control, which could be mediated by exercise-induced humoral factors released in the bloodstream. Here, we used C57Bl/6 healthy mice, submitted to resistance training for 10 weeks. Trained mice presented higher muscle weight and maximum voluntary carrying capacity, combined with reduced body gain fat deposition. improved glucose tolerance glycemia, no alterations insulin sensitivity. In addition, trained displayed insulinemia...
The maternal environment during pregnancy and lactation plays a determining role in programming energy metabolism offspring. Among myriad of factors, disruptions the light/dark cycle can program glucose intolerance Out-of-phase feeding has recently been reported to influence adult humans rodents; however, it is not known whether this environmental factor impacts offspring when applied lactation. This study aims determine day-restricted (DF) influences offspring.Pregnant lactating Wistar rats...
Pancreatic beta cell (β) dysfunction is an outcome of malnutrition. We assessed the role amplifying pathway (AMP PATH) in β cells malnourished obese mice. C57Bl-6 mice were fed a control (C) or low-protein diet (R). The groups then high-fat (CH and RH). AMP PATH contribution to insulin secretion was upon incubating islets with diazoxide KCl. CH RH displayed increased glucose intolerance, resistance glucose-stimulated secretion. Only showed higher PATH. mitochondrial membrane potential...