A5000579453- Pancreatic function and diabetes
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Aldose Reductase and Taurine
- Diabetes and associated disorders
- RNA Research and Splicing
- Cardiovascular Disease and Adiposity
- Nuclear Receptors and Signaling
- Effects and risks of endocrine disrupting chemicals
- Endoplasmic Reticulum Stress and Disease
- Estrogen and related hormone effects
- Metabolism, Diabetes, and Cancer
- High-Velocity Impact and Material Behavior
- Stress Responses and Cortisol
- Indigenous Health and Education
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Sulfur Compounds in Biology
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Ovarian function and disorders
Universidade Estadual de Campinas (UNICAMP)
2019-2024
Universidade Federal do Rio de Janeiro
2015-2019
Universidade Federal de Sergipe
2009
Increased adiposity in perivascular adipose tissue (PVAT) has been related to vascular dysfunction. High-fat (HF) diet-induced obesity models are often used analyze the translational impact of obesity, but differences sex and Western diet type complicate comparisons between studies. The role PVAT was investigated small mesenteric arteries (SMAs) male female mice fed a HF or plus high-sucrose (HF + HS) for 3 5 months compared them age/sex-matched chow diet. Vascular responses SMAs without...
D-pinitol is one of the major inositol found in plants and studies suggest its potential hypoglycemic hypolipidemic actions diabetic rodents. Here, we investigated on adiposity, lipid glycemic homeostasis monosodium glutamate (MSG)-obese mice. Swiss mice received daily subcutaneous injections MSG [(4g/kg body weight (BW)] or saline [1.25g/kg BW; control (CTL)] during their first five days life. From 90-120 day-old, half CTL groups 50 mg D-pinitol/kg BW/day (MPIN CPIN groups) vehicle (saline;...
Bisphenol-A (BPA) is an endocrine disruptor associated with higher risk of insulin resistance, type 2 diabetes, and cardiovascular diseases especially in susceptible populations. Because malnutrition a nutritional disorder high risk, we sought to compare the effects short-term BPA exposure on parameters healthy protein-malnourished mice. Postweaned male mice were fed normo- (control) or low-protein (LP) diet for 8 weeks then exposed not (50 μg kg −1 day ) last 9 days. Systolic blood pressure...
Abstract The COVID-19 pandemic was initiated by the rapid spread of a SARS-CoV-2 strain. Though mainly classified as respiratory disease, infects multiple tissues throughout human body, leading to wide range symptoms in patients. To better understand how affects proteome from cells with different ontologies, this work generated an infectome atlas 9 cell models, including brain, blood, digestive system, and adipocyte tissue. Our data shows that infection trigger dysregulations on proteins...
Abstract Background The maintenance of skeletal muscle plasticity upon changes in the environment, nutrient supply, and exercise depends on regulatory mechanisms that couple structural metabolic adaptations. interconnect both processes at transcriptional level remain underexplored. Nr2f6, a nuclear receptor, regulates metabolism cell differentiation peripheral tissues. However, its role is still elusive. Here, we aimed to investigate effects Nr2f6 modulation biology vivo vitro . Methods...
Obesity predisposes to glucose intolerance and type 2 diabetes (T2D). This disease is often characterized by insulin resistance, changes in clearance, β-cell dysfunction. However, studies indicate that, for T2D development, disruptions glucagon physiology also occur. Herein, we investigated the involvement of impaired glycemia control monosodium glutamate (MSG)-obese mice. Male Swiss mice were subcutaneously injected daily, during first 5 days after birth, with MSG (4 mg/g body weight [BW])...
Since prenatal glucocorticoids (GC) excess increases the risk of metabolic dysfunctions in offspring and its effect on β-cell recovery capacity remains unknown we investigated these aspects from mice treated with dexamethasone (DEX) late pregnancy. Half pups were streptozotocin (STZ) sixth postnatal day (PN). Functional molecular analyses performed male PN25 PN225. Prenatal DEX treatment resulted low birth weight. At PN25, both STZ-treated developed hyperglycemia had lower mass, parallel...
Abstract Objective The maintenance of skeletal muscle plasticity upon changes in the environment, nutrient supply, and exercise depends on regulatory mechanisms that couple structural metabolic adaptations. However, interconnect both processes at transcriptional level remain underexplored. Nr2f6, a nuclear receptor, regulates metabolism cell differentiation peripheral tissues. its role is still elusive. Here, we aimed to investigate, for first time, effects Nr2f6 modulation biology vivo...