A5006139318- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Immune Cell Function and Interaction
- Cell death mechanisms and regulation
- Psoriasis: Treatment and Pathogenesis
- Oral microbiology and periodontitis research
- Autophagy in Disease and Therapy
- T-cell and B-cell Immunology
- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Signaling Pathways in Disease
- Photodynamic Therapy Research Studies
- Antioxidant Activity and Oxidative Stress
- Dental Research and COVID-19
- Laser Applications in Dentistry and Medicine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Atherosclerosis and Cardiovascular Diseases
- Peroxisome Proliferator-Activated Receptors
- IL-33, ST2, and ILC Pathways
- CAR-T cell therapy research
- Oral Health Pathology and Treatment
- Dietary Effects on Health
- Genomics, phytochemicals, and oxidative stress
Universidade Estadual de Campinas (UNICAMP)
2004-2025
Pontifícia Universidade Católica de Campinas
2018-2025
Pontifícia Universidade Católica de São Paulo
2018-2025
Institute of Molecular Biology and Biophysics
2016
Ulrich Medical (Germany)
2009
Elisa (Finland)
2009
In animal models of diet-induced obesity, the activation an inflammatory response in hypothalamus produces molecular and functional resistance to anorexigenic hormones insulin leptin. The primary events triggered by dietary fats that ultimately lead hypothalamic cytokine expression signaling are unknown. Here, we test hypothesis act through toll-like receptors 2/4 endoplasmic reticulum stress induce rodents. According our results, long-chain saturated fatty acids activate predominantly...
In diet-induced obesity, hypothalamic and systemic inflammatory factors trigger intracellular mechanisms that lead to resistance the main adipostatic hormones, leptin insulin. Tumor necrosis factor-α (TNF-α) is one of produced during this process its mechanistic role as an inducer insulin has been widely investigated. Most TNF-α signals are delivered by TNF receptor 1 (R1); however, played in context obesity-associated inflammation not completely known. Here, we show TNFR1 knock-out (TNFR1...
Tissue homeostasis and regeneration depend on differentiated stem cells into specialized cell types. Dietary interventions, such as caloric restriction, are critical regulators of functions by altering their metabolism. This review discusses recent studies illustrating how diet interventions impact function. We summarize molecular targets physiological effects different types restriction ketogenic mimicking diets in from bone marrow, muscle, intestine. Furthermore, we highlight the...
This mini-review aimed to present an outlook on childhood obesity and leukemia in different regions of Brazil explore a possible association between biological aspects related adipose tissue cancer. We emphasized environmental factors that may influence cancer development studies showing prevalences these diseases Brazilian regions. However, future are required determine how contribute adolescence. Furthermore, we also be associated with leukemia, considering the disease development.
<i>Objective:</i> The aim of this investigation was to study the effect vitamin E treatment in oxidative stress red and white cells β-thalassaemia intermedia patients. <i>Methods:</i> Nine patients undergoing occasional transfusions (5 females/4 males), median age 39 years (range 15–74), were recruited for oral daily administration 400 IU 3 months. Twenty-seven milliliters peripheral blood obtained before after months treatment, completion. In case transfused (n = 4),...
Uncoupling protein 2 (UCP2) is highly expressed in the hypothalamus; however, little known about functions it exerts this part of brain. Here, we hypothesized that UCP2 protects hypothalamic cells from oxidative and pro‐apoptotic damage generated by inflammatory stimuli. Intracerebroventricular injection tumor necrosis factor alpha (TNF‐α)‐induced an increase expression hypothalamus, which was accompanied increased markers stress proteins. The inhibition antisense oligonucleotide enhanced...
Background Several effects of leptin in the immune system rely on its capacity to modulate cytokine expression and apoptosis thymus. Surprisingly, some these are dependent signal transduction through IRS1/PI3-kinase, but not activation JAK2. Since all well known different cell types tissues seem be JAK2 activation, we hypothesized that, at least for control thymic function, another, unknown kinase could mediate from ObR towards IRS1/PI3-kinase signaling cascade. Methodology/Principal...
Periodontal disease is of inflammatory origin and affects the dental support tissues. The initial phase characterized by accumulation biofilm, which a predisposing factor for several oral pathologies. combination extrinsic factors such as lack hygiene, smoking diet, intrinsic genetics, major changes in immune response associated with escape mechanisms biofilm constituents are crucial to development progression disease, when untreated entails local irreversible consequences that can lead...
The present study provides evidence that activated spleen lymphocytes from Walker 256 tumor bearing rats are more susceptible than controls to tert-butyl hydroperoxide (t-BOOH)-induced necrotic cell death in vitro. iron chelator and antioxidant deferoxamine, the intracellular Ca2+ BAPTA, L-type channel antagonist nifedipine or mitochondrial permeability transition inhibitor cyclosporin A, but not calcineurin FK-506, render control equally resistant toxic effects of t-BOOH. Incubation...
Purpose Evaluate tryptophan and thymine (TT) impact on carcinogenesis intravesical BCG bladder cancer treatment.Methods After identification of TT in vitro inhibitory effect multiple cell cultures, animal model was induced by MNU instillations randomized into four groups: Control (n = 9), 7), + 8). groups received 106 CFU 0.2 ml saline for 6 consecutive weeks 1 g/kg (1:1) via daily gavage. 15 wk protocol, animals were euthanized the urinary bladders submitted to histopathology,...