A5042901188- Liver Disease Diagnosis and Treatment
- Studies on Chitinases and Chitosanases
- Birth, Development, and Health
- Insect Utilization and Effects
- Silk-based biomaterials and applications
- Fungal Infections and Studies
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Infectious Diseases and Mycology
- Neurobiology and Insect Physiology Research
- Toxoplasma gondii Research Studies
- Bee Products Chemical Analysis
- Mosquito-borne diseases and control
- Healthcare Regulation
- Effects and risks of endocrine disrupting chemicals
- Pesticide and Herbicide Environmental Studies
- Diet, Metabolism, and Disease
- Pesticide Exposure and Toxicity
- Healthcare during COVID-19 Pandemic
- Plant-Microbe Interactions and Immunity
- Public Health in Brazil
- Antifungal resistance and susceptibility
Centro Universitário Fundação Assis Gurgacz
2022
Universidade Estadual do Oeste do Paraná
2017-2021
Universidade de São Paulo
2014-2015
Background Paracoccin (PCN) is an N-acetylglucosamine-binding lectin from the human pathogenic fungus Paracoccidioides brasiliensis. Recombinant PCN (rPCN) induces a T helper (Th) 1 immune response when prophylactically administered to BALB/c mice, protecting them against subsequent challenge with P. In this study, we investigated therapeutic effect of rPCN in experimental paracoccidioidomycosis (PCM) and mechanism accounting for its beneficial action. Methodology/Principal Findings Four...
To investigate the effects of sericin extracted from silkworm Bombyx mori cocoon on morphophysiological parameters in mice with obesity induced by high-fat diet.Male C57Bl6 aged 9 weeks were allocated to one two groups - Control and Obese, fed a standard or diet for 10 weeks, respectively. Mice then further subdivided into four seven each, as follows: Control, Control-Sericin, Obese-Sericin. The high fat was given 4 more weeks; (1,000mg/kg body weight) orally Control-Sericin Obese-Sericin...
Toxoplasma gondii is an obligate intracellular protozoan parasite found worldwide that able to chronically infect almost all vertebrate species, especially birds and mammalians. Chitinases are essential various biological processes, some pathogens rely on chitinases for successful parasitization. Here, we purified characterized a chitinase from T. gondii. The enzyme, provisionally named Tg_chitinase, has molecular mass of 13.7 kDa exhibits Km 0.34 mM Vmax 2.64. optimal environmental...
Paracoccidioidomycosis is the most prevalent systemic mycosis in Latin America. It caused by temperature-dependent dimorphic fungus Paracoccidioides brasiliensis. The P. brasiliensis cell wall a dynamic outer structure, composed of network glycoproteins and polysaccharides, such as chitin, glucan N-glycosylated proteins. These can interact with host to affect infection rates, are known perform other functions. We inhibited N-linked glycosylation using tunicamycin (TM), then evaluated...
Objective: To investigate the effect of pre and postnatal exposure to a glyphosate-based herbicide on glucose metabolism liver histology in adult F1 mice offspring. Methods: Female (C57Bl/6) received 0.5% glyphosate (Roundup Original DI®) drinking water or purified (Glyphosate Group Control respectively) during pregnancy lactation. Offspring (F1) were submitted insulin tolerance tests euthanized day 150. Body plasma parameters, analyzed. Results: Exposure [...]
Abstract Maternal obesity increases the risk of nonalcoholic fatty liver disease (NAFLD) in offspring. The Roux-en-Y gastric bypass (RYBG) is effective for achieving weight loss and ameliorates NAFLD. To determine whether these benefits are maintained after pregnancy and/or lactation, they modulate hepatic morphofunction next generation, we evaluated lipid metabolism Western diet (WD)-obese female rats that underwent RYGB their F1 offspring at adulthood. Female Wistar consumed a WD from 21...
RESUMO: O diabetes mellitus é uma doença crônica em que ocorre hiperglicemia e acarreta várias alterações ao longo da vida dos pacientes. Diante das mudanças todos os âmbitos devido a Covid-19, o estudo epidemiológico realizado mostrou queda na incidência casos de Diabetes Mellitus diagnosticado no período 01 janeiro 2015 até 31 julho 2021, podendo ser relacionado direcionamento ambulatórios para atendimento exclusivo pacientes contraíram covid-19.