A5026169679- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Sleep and Wakefulness Research
- Memory and Neural Mechanisms
- Cannabis and Cannabinoid Research
- Regulation of Appetite and Obesity
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Prenatal Substance Exposure Effects
- Biochemical Analysis and Sensing Techniques
- Healthcare during COVID-19 Pandemic
- Family Support in Illness
- Educational Games and Gamification
- Online Learning and Analytics
- Sexual function and dysfunction studies
- Olfactory and Sensory Function Studies
- Urban Green Space and Health
- Food Safety and Hygiene
- Intergenerational Family Dynamics and Caregiving
- Neural dynamics and brain function
- Birth, Development, and Health
- Nerve injury and regeneration
- Psychedelics and Drug Studies
Universidade Federal do Espírito Santo
2021-2024
Universidade Federal de São Paulo
2011-2023
Hallucinogenic drugs were used to treat alcoholic patients in the past, and recent developments study of hallucinogens led a renewal interest regarding application these treatment addiction. In this scenario, accumulating evidence suggests that hallucinogenic brew ayahuasca (Aya) may have therapeutic effects on substance abuse problems. We investigated Aya spontaneous locomotor activity ethanol(Eth)-induced hyperlocomotion subsequent sensitization by two-injection protocol. Additionally, we...
The endocannabinoid system has been implicated in the neurobiological mechanism underlying drug addiction, especially primary rewarding dopamine-dependent processes. Therefore, receptor antagonists, such as CB1 cannabinoid antagonist rimonabant, have proposed candidates for preventive addiction therapies.Investigate possible involvement of receptors development behavioral sensitization to ethanol, morphine and cocaine mice.We compared effects different doses rimonabant (0.3, 1, 3 10mg/kg) on...
ABSTRACT Repeated or even a single exposure to drugs of abuse can lead persistent locomotor sensitization, which is the result an abundance neuroplastic changes occurring within circuitry involved in motivational behavior and thought play key role certain aspects drug addiction. There substantial controversy about addictive potential modafinil, wake‐promoting used treat narcolepsy that increasingly being as cognitive enhancer has been proposed pharmacotherapy for cocaine dependence. Male...
Drug-induced behavioral sensitization in rodents has enhanced our understanding of why drugs acquire increasing motivational and incentive value. Compared to adults, human adolescents have accelerated dependence courses with shorter times from first exposure dependence. We compared adolescent adult mice their ability develop amphetamine following a single injection. Adult (90-day-old) (45-day-old) male Swiss received an acute intraperitoneal injection saline or (1.0, 2.0 4.0 mg/kg). Seven...
An increased function in the mesolimbic dopaminergic system has been extensively associated with rewarding effects of both natural stimuli and drugs abuse. Thus, dopamine receptor blockers, such as neuroleptic drugs, can be proposed candidates for potential therapeutic approaches to treat drug dependence. Notwithstanding, this neuroleptics critically depends on a selective action specific mechanisms related development addiction. We compared different doses haloperidol, ziprasidone...
Summary It has been suggested that the high prevalence of drug abuse in schizophrenics is related to chronic treatment with typical neuroleptics and dopaminergic supersensitivity develops as a consequence. Within this context, atypical do not seem induce phenomenon. In present study, we investigated effects acute administration or withdrawal from long‐term haloperidol and/or ziprasidone on morphine‐induced open‐field behaviour mice. first experiment, mice were given single injection (1...
There is substantial controversy about the addictive potential of modafinil, a wake-promoting drug used to treat narcolepsy, proposed as pharmacotherapy for cocaine abuse, and indiscriminately by healthy individuals due its positive effects on arousal cognition. The rapid-onset type behavioral sensitization (i.e., that develops within few hours from priming administration) has been emerged valuable tool study binge-like patterns abuse neuroplastic changes occur quickly after administration...
Sleep deprivation is common place in modern society. Nowadays, people tend to self-impose less sleep order achieve professional or social goals. In the context, late-night parties are frequently associated with higher availability of recreational drugs abuse potential. Physiologically, all these induce an increase dopamine release mesolimbic dopaminergic system, which leads hyperlocomotion rodents. also seems play important role events related neurotransmission system by potentiating its...
The aim of this study was to investigate socioeconomic stressors predictive depressive symptoms and possible epigenetic changes in the glucocorticoid receptor – NR3C1-1F an encoding gene involved symptoms. A total 321 adult volunteers from southeastern Brazil were recruited evaluate symptoms, socio-demographic economic factors, including food nutritional security (FNS) or insecurity (FNiS) status, region methylation by pyrosequencing. Depressive symptom determinants investigated using a...
Studies on the abuse potential of modafinil, a psychostimulant-like drug used to treat narcolepsy, are still controversial. While some studies claim no for abuse, increasing evidence suggests that modafinil induces abuse-related effects, including rapid-onset behavioral sensitization (i.e., type develops within hours from priming administration). The paradigm is valuable tool study neuroplastic changes occur quickly after administration, and shares neuroadaptations with in humans. However,...
Food restriction (FR) seems to be the unique experimental manipulation that leads a remarkable increase in lifespan rodents. Evidences have suggested FR can enhance memory distinct animal models mainly during aging. However, only few studies systemically evaluated effects on formation both adult (3-month-old) and aged (18-24-month-old) mice. Thus, aim of present study was investigate acute (12h) or repeated (12h/day for 2days) protocols learning mice plus-maze discriminative avoidance task...
Introduction: The endocannabinoid system has been implicated in the neurobiology of opioid use disorder. While CB1 receptor antagonist rimonabant shown to block some behavioral effects opioids, studies suggest that treatment environment (i.e., receiving drug-associated environment, and/or novelty) can influence its effects. In present study, we investigated role on expression morphine-induced sensitization. Methods: Adult female Swiss mice were submitted a sensitization protocol, during...
Evidence suggests that aripiprazole, a partial dopamine D2 and serotonin 5-HT1A receptor agonist 5-HT2A antagonist, show significant efficacy in reducing alcohol use. We have previously demonstrated treatment with aripiprazole blocked the reinstatement of cocaine-induced behavioral sensitization context-dependent manner, suggesting environment may modulate therapeutic effects aripiprazole. The present study aimed to evaluate on ethanol-induced conditioned place preference female mice, role...
CB1 receptor antagonists have been shown to prevent acute and long-term behavioral effects of cocaine. Here we evaluate the effectiveness antagonist rimonabant modify sensitized responses Mice were treated with saline or cocaine injections in a 15-day intermittent sensitization treatment subsequently either vehicle, 1 10mg/kg drug-associated environment for 8 consecutive days. Animals then challenged open-field apparatus on subsequent days expression conditioned c-Fos protein was evaluated...
Screener, a board game supplemented with online resources, was introduced and distributed by the Brazilian Society of Pharmacology Experimental Therapeutics to postgraduate programs as an instructional tool for process drug discovery development (DDD). In this study, we provided comprehensive analysis five critical aspects evaluating quality educational games, namely: 1) description intervention; 2) underlying pedagogical theory; 3) identification local gaps; 4) impact on diverse...