A5034836859- Neurotransmitter Receptor Influence on Behavior
- Psychedelics and Drug Studies
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Cannabis and Cannabinoid Research
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Tryptophan and brain disorders
- Phytochemistry and Biological Activities
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Chemical synthesis and alkaloids
- Pain Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Phytochemical and Pharmacological Studies
- Psychology Research and Bibliometrics
- Urban Green Space and Health
- Morinda citrifolia extract uses
- Drug-Induced Hepatotoxicity and Protection
- Probiotics and Fermented Foods
- Neuropeptides and Animal Physiology
- Insect and Pesticide Research
- Sesquiterpenes and Asteraceae Studies
- Diet and metabolism studies
Universidade Estadual de Santa Cruz
2014-2024
Universidade Federal de São Paulo
2011-2023
Universidade Braz Cubas
2009
Hallucinogenic drugs were used to treat alcoholic patients in the past, and recent developments study of hallucinogens led a renewal interest regarding application these treatment addiction. In this scenario, accumulating evidence suggests that hallucinogenic brew ayahuasca (Aya) may have therapeutic effects on substance abuse problems. We investigated Aya spontaneous locomotor activity ethanol(Eth)-induced hyperlocomotion subsequent sensitization by two-injection protocol. Additionally, we...
The aims of this study were to assess the impact ceremonial use ayahuasca-a psychedelic brew containing N,N-dimethyltryptamine (DMT) and β-carboline -and attendance at União do Vegetal (UDV) meetings on substance abuse; here we report findings related alcohol tobacco disorder. A total 1,947 members UDV 18+ years old evaluated in terms membership during previous 12 months. Participants recruited from 10 states all major regions Brazil. Alcohol was through questionnaires first developed by...
Psychobiotics correspond to a class of probiotics, mainly the genus Lactobacillus and Bifidobacterium, capable producing neuroactive substances, such as γ-aminobutyric acid (GABA) serotonin, which exert effects on brain-gut axis. Evidence suggests that psychobiotics can have beneficial effect mood, anxiety cognition. The present study evaluated chronic administration two new strains plantarum, L. plantarum 286 (Lp 286) 81 81) isolated from fermentation cocoa (Theobroma cacao L.) cupuaçu...
The endocannabinoid system has been implicated in the neurobiological mechanism underlying drug addiction, especially primary rewarding dopamine-dependent processes. Therefore, receptor antagonists, such as CB1 cannabinoid antagonist rimonabant, have proposed candidates for preventive addiction therapies.Investigate possible involvement of receptors development behavioral sensitization to ethanol, morphine and cocaine mice.We compared effects different doses rimonabant (0.3, 1, 3 10mg/kg) on...
Ayahuasca is a hallucinogenic beverage produced from the decoction of Banisteriopsis caapi (Bc) and Psychotria viridis (Pv), β-carboline- N,N-dimethyltryptamine(DMT)-containing plants, respectively. Accumulating evidence suggests that ayahuasca may have therapeutic effects on ethanol abuse. It not known, however, whether its are dependent presence DMT or if non-DMT-containing components would effects. The aim present study was to investigate rewarding properties (30, 100 300 mg/kg, orally),...
An increased function in the mesolimbic dopaminergic system has been extensively associated with rewarding effects of both natural stimuli and drugs abuse. Thus, dopamine receptor blockers, such as neuroleptic drugs, can be proposed candidates for potential therapeutic approaches to treat drug dependence. Notwithstanding, this neuroleptics critically depends on a selective action specific mechanisms related development addiction. We compared different doses haloperidol, ziprasidone...
Studies on the abuse potential of modafinil, a psychostimulant-like drug used to treat narcolepsy, are still controversial. While some studies claim no for abuse, increasing evidence suggests that modafinil induces abuse-related effects, including rapid-onset behavioral sensitization (i.e., type develops within hours from priming administration). The paradigm is valuable tool study neuroplastic changes occur quickly after administration, and shares neuroadaptations with in humans. However,...
The CB1 receptor antagonist rimonabant has been previously found to prevent behavioral effects of drugs abuse in a context-dependent manner, suggesting an important role endocannabinoid signaling drug-induced environmental conditioning. aim the present study was evaluate on ethanol-induced conditioned place preference (CPP) female mice.Animals were with saline or ethanol (1.8g/kg) during 8 sessions, and subsequently treated either (1 10mg/kg) CPP environment associated (unpaired) (paired)...
Solidago chilensis (syn. microglossa) is a plant from the Asteraceae family widely distributed in South America and used to treat inflammatory diseases. In 2009, it was listed as one of native medicinal herbal plants Brazilian public health system. addition its anti-inflammatory properties, recent clinical study has shown antinociceptive effects S. chilensis, introducing new potential medical use for this plant. The aim present investigate activity hydroalcoholic extract (HESc) rodent models...
Introduction: The endocannabinoid system has been implicated in the neurobiology of opioid use disorder. While CB1 receptor antagonist rimonabant shown to block some behavioral effects opioids, studies suggest that treatment environment (i.e., receiving drug-associated environment, and/or novelty) can influence its effects. In present study, we investigated role on expression morphine-induced sensitization. Methods: Adult female Swiss mice were submitted a sensitization protocol, during...
Evidence suggests that aripiprazole, a partial dopamine D2 and serotonin 5-HT1A receptor agonist 5-HT2A antagonist, show significant efficacy in reducing alcohol use. We have previously demonstrated treatment with aripiprazole blocked the reinstatement of cocaine-induced behavioral sensitization context-dependent manner, suggesting environment may modulate therapeutic effects aripiprazole. The present study aimed to evaluate on ethanol-induced conditioned place preference female mice, role...
CB1 receptor antagonists have been shown to prevent acute and long-term behavioral effects of cocaine. Here we evaluate the effectiveness antagonist rimonabant modify sensitized responses Mice were treated with saline or cocaine injections in a 15-day intermittent sensitization treatment subsequently either vehicle, 1 10mg/kg drug-associated environment for 8 consecutive days. Animals then challenged open-field apparatus on subsequent days expression conditioned c-Fos protein was evaluated...
Ibogaine is a psychedelic extracted from the plant Tabernanthe iboga Baill. (Apocynaceae) , natural Africa, and has been proposed as potential treatment for substance use disorders. In animal models, ibogaine reduces ethanol self-administration. However, no study to date investigated effects of on ethanol-induced conditioned place preference (CPP). The present aimed investigate repeated with reinstatement CPP in male mice. rewarding (1.8 g/kg, i. p.) or (10 30 mg/kg, p. o.) were using model....
Pain is a distressful experience that can have major impact on an individual’s quality of life. The need for new and better analgesics has been further intensified in light the current opioid epidemic. Substances obtained from amphibians shown to contain bioactive peptides exert analgesic effects. genus Phyllomedusa represents important source components. aim this study was investigate antinociceptive effects skin secretion rohdei rodent models pain. crude extract P. tested different pain...
Ayahuasca has been proposed as a treatment for substance use disorders. However, because of its hallucinogenic properties, studies investigating abuse potential are needed. The aim the present study was to investigate voluntary ayahuasca drinking in male mice using two-bottle choice procedure. Male were exposed two bottles, one water and (0.01, 0.03 or 0.1 mg/ml), 15 h/day, under 3 protocols (acquisition): (1) every other day access; (2) access days; (3) 5 days. Animals then submitted 14-day...
Introduction The aim of the present study was to investigate behavioral effects benzodiazepine midazolam in male mice, models anxiolysis, learning, and abuse-related effects. Methods In a first set experiments, Swiss mice were submitted training session discriminative avoidance (DA) task on elevated plus maze evaluate anxiety-like behavior learning after vehicle or (1, 2 5 mg/kg, i.g.) administration. same animals conditioned place preference (CPP) protocol with i.g.). second experiment,...