A5086954262- Forensic Toxicology and Drug Analysis
- Psychedelics and Drug Studies
- Cannabis and Cannabinoid Research
- Analytical chemistry methods development
- Neurotransmitter Receptor Influence on Behavior
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Hormonal and reproductive studies
- Pesticide Residue Analysis and Safety
- Alcohol Consumption and Health Effects
- Opioid Use Disorder Treatment
- Neuroscience and Neuropharmacology Research
- Electrochemical sensors and biosensors
- Biochemical Analysis and Sensing Techniques
- Teacher Education and Leadership Studies
- Collaborative Teaching and Inclusion
- Pharmacological Effects and Assays
- Microfluidic and Capillary Electrophoresis Applications
- Forensic Fingerprint Detection Methods
- Poisoning and overdose treatments
- Advanced Chemical Sensor Technologies
- Biosimilars and Bioanalytical Methods
- Sexual Differentiation and Disorders
Universidade Estadual de Campinas (UNICAMP)
2016-2025
Hospital de Clínicas da Unicamp
2020-2021
Pharmaceutical Biotechnology (Czechia)
2020
Pontifícia Universidade Católica de Campinas
2020
Federal Police of Brazil
2009-2016
National Institute on Drug Abuse
2014-2015
National Institutes of Health
1982-2015
Universidade de São Paulo
2001-2014
University of Alberta
1996-2008
Universidade Federal do Paraná
2008
The prevalence of marijuana use among pregnant women is high. However, the effects on gestation and fetal development are not well known. Epidemiological experimental studies present conflicting results because route administration, dose, time exposure, species used, how Cannabis toxicity tested (prepared extracts, specific components, or by pyrolysis). In this study, we experimentally investigated maternal inhalation sativa smoke representing as nearly possible real world conditions human...
Hallucinogenic drugs were used to treat alcoholic patients in the past, and recent developments study of hallucinogens led a renewal interest regarding application these treatment addiction. In this scenario, accumulating evidence suggests that hallucinogenic brew ayahuasca (Aya) may have therapeutic effects on substance abuse problems. We investigated Aya spontaneous locomotor activity ethanol(Eth)-induced hyperlocomotion subsequent sensitization by two-injection protocol. Additionally, we...
New psychoactive substances (NPS) are a major public health problem, primarily due to the increased number of acute poisoning cases. Detection these is challenge. The aim this research was develop and validate sensitive screening method for 104 drugs abuse, including synthetic cannabinoids, cathinones, fentanyl analogues, phenethylamines other abused compounds (i.e., THC, MDMA, LSD their metabolites) in oral fluid by liquid chromatography-tandem mass spectrometry (LC-MS-MS). Quantisal™...
Background Sodium-glucose cotransporter 2 (SGLT2) inhibitors attenuate incident cardiovascular outcomes, irrespective of baseline GFR, in conservatively managed CKD. As this condition inexorably progresses to demanding KRT, drug withdrawal is supported by the current lack evidence safety SGLT2 dialysis. Methods This study was a prospective, single-center, open-label trial (ClinicalTrials.gov identifier: NCT05343078) aimed at assessing pharmacokinetic properties and dapagliflozin patients...
Abstract New psychoactive substances (NPS) are often synthesized via small changes in the molecular structure, producing drugs whose effect and potency not yet fully known. Ketamine is one of oldest NPS, with therapeutic use human veterinary medicine authorized several countries, being metabolized mainly into norketamine 6-hydroxy-norketamine. Furthermore, two structural analogues ketamine have recently been identified, deschloroketamine 2-fluorodeschloroketamine, marketed as abuse. To...
Abstract Synthetic cathinones continue to proliferate in clandestine drug markets worldwide. N ‐ethylnorpentylone (also known as ‐ethylpentylone or ephylone) is a popular emergent cathinone, yet little information available about its toxicology and pharmacology. Here we characterize the analytical quantification, clinical presentation, pharmacological mechanism of action for ‐ethylnorpentylone. Liquid chromatography coupled tandem mass spectrometry (LC–MS/MS) was used quantify blood obtained...
Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It known that host microRNAs (miRNAs) can be modulated to favor viral infection or protect the host. Herein, we report preliminary results of study aiming at identifying differentially expressed plasmatic miRNAs in Brazilian patients with COVID-19.miRNAs were extracted from plasma eight COVID-19 (four mild and four severe/critical COVID-19) healthy controls....
New Psychoactive Substances (NPSs) are defined as a group of substances produced from molecular modifications traditional drugs. These molecules represent public health problem since information about their metabolites and toxicity is poorly understood. N-ethyl pentedrone (NEP) an NPS that was identified in the illicit market for first time mid-2010s, with four intoxication cases later described literature. This study aims to evaluate metabolic stability NEP well identify its using three...
While illicit opioids have not been historically significant in Brazil, these numbers increased the last few years. This change drug scenario is mainly associated with synthetic opioids, a class of new psychoactive substances (NPS). In this context, present article describes detailed information about recent cases seized especially nitazenes group. All analyses were carried out by Superintendence Technical-Scientific Police - Narcotics Control Center (STSP-NCC) São Paulo, between July 2022...
The ritualistic use of ayahuasca is becoming a global phenomenon. This beverage contains combination monoamine oxidase inhibitors (harmine, harmaline, and tetrahydroharmine) N,N-dimethyltryptamine, the main substance responsible for its visionary effect. recreational similar alkaloids N,N-dimethyltryptamine has increased in recent years, mainly because their hallucinogenic effects. In present study, concentrations psychoactive three powder samples seized by São Paulo State Police nine...
We report the discovery of marinoquinoline (3H-pyrrolo[2,3-c]quinoline) derivatives as new chemotypes with antiplasmodial activity. evaluated their inhibitory activities against P. falciparum and conducted a structure–activity relationship study, focusing on improving potency maintaining low cytotoxicity. Next, we devised quantitative (QSAR) models, which prospectively validated, to discover analogues enhanced potency. The most potent compound, 50 (IC503d7 = 39 nM; IC50K1 41 nM), is...
This work describes results of chemical profiling by gas chromatography with flame ionization detector (GC-FID) the main components (purity, oxidation level, and cutting agents) in 642 street cocaine samples seized five different Brazilian States between 2011 2014.The analysis revealed presence mean content 49.8%.Freebase showed average 66.0%, whereas hydrochloride not determined (n.d.) present 44.5% 11.8%, respectively.Cocaine base show moderately (16%) to oxidized (81%) levels, exhibit...
Ayahuasca is a hallucinogenic beverage produced from the decoction of Banisteriopsis caapi (Bc) and Psychotria viridis (Pv), β-carboline- N,N-dimethyltryptamine(DMT)-containing plants, respectively. Accumulating evidence suggests that ayahuasca may have therapeutic effects on ethanol abuse. It not known, however, whether its are dependent presence DMT or if non-DMT-containing components would effects. The aim present study was to investigate rewarding properties (30, 100 300 mg/kg, orally),...
The aim of this work was to develop a simple and fast method for the detection paraquat in oral fluid, plasma, urine by capillary electrophoresis with diode-array (CE-DAD), diagnose acute poisoning related herbicide. use fluid analytical toxicology has been established drugs abuse, but not diagnosis pesticides poisoning. Oral collected without stimulation using absorbent cotton swabs. Sample preparation included diluting, vortex mixing, centrifuging biological ethyl as internal standard....
Abstract In this work, two methods were developed to determine herbicides paraquat, glyphosate, and aminomethylphosphonic acid ( AMPA ) in marijuana samples by capillary electrophoresis. For paraquat analysis, sample was extracted with aqueous acetic solution analyzed zone electrophoresis direct UV detection. The running electrolyte 50 mmol/L phosphate buffer (p H 2.50). glyphosate , indirect / VIS detection used, as these substances do not present chromophoric groups. Samples 5 hydrochloric...
Abstract The content of ecstasy tablets has been changing over the years, and nowadays 3,4‐methylenedioxymethamphetamine ( MDMA ) is not always present in tablets. aim this study was to investigate chemical composition seized labeled as ecstasy. We analyzed samples from 150 different seizures made by Sao Paulo's State Police gas chromatography–mass spectrometry. 44.7% samples, another twenty active substances were identified these tablets, such caffeine, 2C‐B, piperazines, amphetamines,...