A5013755965- Agricultural and Food Sciences
- Malaria Research and Control
- Healthcare Regulation
- Computational Drug Discovery Methods
- Mosquito-borne diseases and control
- Academic Research in Diverse Fields
- Phytochemistry Medicinal Plant Applications
- Food, Nutrition, and Cultural Practices
- Business and Management Studies
- Science and Education Research
- Brazilian Legal Issues
- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Physical Education and Sports Studies
- Immune Response and Inflammation
- Synthesis and Characterization of Heterocyclic Compounds
- Trypanosoma species research and implications
- Physical Education and Gymnastics
- Banana Cultivation and Research
- Consumer Attitudes and Food Labeling
- Clinical Nutrition and Gastroenterology
- Phytochemistry and Bioactivity Studies
- Thermal Regulation in Medicine
- Indigenous Health and Education
- Rural Development and Agriculture
Universidade de São Paulo
1995-2025
Czech Academy of Sciences, Institute of Physics
2025
Universidade Iguaçu
2024
Universidade Federal Fluminense
2015-2024
Centro de Tecnologias Estratégicas do Nordeste
2024
Universidade Federal de São Carlos
2021-2023
National Council for Scientific and Technological Development
2022
Governo do Estado de São Paulo
2022
Financiadora de Estudos e Projetos
2022
Universidade Federal de Campina Grande
2018
This study was designed to determine if the febrile response, similar inflammatory can be modulated by endogenous glucocorticoids. A single intraperitoneal injection of lipopolysaccharide (LPS, 200 micrograms/kg) induced a significant increase in rectal temperature unrestrained rats maintained within thermoneutral zone. The response fully abolished following treatment with glucocorticoid, dexamethasone (DEX), but not affected mineralocorticoid, deoxycorticosterone acetate (DOCA)....
We have studied the mechanism by which interleukin-8 (IL-8) induces fever in rats. Intracerebroventricular injections of IL-8 (5.5-50 ng) evoked dose-dependent increases body temperature, reached a plateau 5 h after injection, i.e., later than intracerebroventricular interleukin-1 beta (IL-1 beta; 2 h). The pyrogenic activity was not due to contamination with lipopolysaccharide (LPS) because preincubation specific antibody or boiling for 30 min abolished its but that LPS; also, LPS induced...
We report the discovery of marinoquinoline (3H-pyrrolo[2,3-c]quinoline) derivatives as new chemotypes with antiplasmodial activity. evaluated their inhibitory activities against P. falciparum and conducted a structure–activity relationship study, focusing on improving potency maintaining low cytotoxicity. Next, we devised quantitative (QSAR) models, which prospectively validated, to discover analogues enhanced potency. The most potent compound, 50 (IC503d7 = 39 nM; IC50K1 41 nM), is...
The isolation and identification of a series new pseudoceratidine (1) derivatives from the sponge Tedania brasiliensis enabled evaluation their antiparasitic activity against Plasmodium falciparum, Leishmania (Leishmania) amazonensis, infantum, Trypanosoma cruzi, causative agents malaria, cutaneous leishmaniasis, visceral Chagas disease, respectively. 3-debromopseudoceratidine (4), 20-debromopseudoceratidine (5), 4-bromopseudoceratidine (6), 19-bromopseudoceratidine (7),...
O uxi é uma espécie botânica pertencente à família Humiriaceae, cujo nome científico Endopleura uchi. É planta nativa da Amazônia brasileira, dispersa pela Região Norte, nos estados do Acre, Amazonas, Amapá, Pará, Rondônia e Tocantins. popular de uso mais frequente uxi, palavra vocabulário tupinambá, sem significado aparente, mas também a conhecida pelas seguintes denominações comuns: axuá, cumatê, paruru, pururu, uchí, uxi-pucu, uxi-liso, uxiverdadeiro uxi-amarelo. Esta possui flores...
Malaria is a disease caused by pathogenic protozoa Plasmodium spp., with significant global impact on human health. Increasing resistance of P. falciparum strains to drugs treating malaria highlights the urgent need for discovery new antimalarial candidates. Batzelladines are marine guanidine alkaloids that exhibit potent antiparasitic activity. Herein, results parasitological profiling assessment batzelladines F and L reported. Both compounds exhibited antiplasmodial activity, moderate...
Ischemia-reperfusion procedures induced severe hepatic damages owing to different processes related hypoxia and reoxygenation (H/R) phases, including the consecutive oxygen free radical (OFR) release. Stress-activated protein kinases (SAPKs) could be activated by extracellular stimuli. The aim of this study was show whether H/R stress conditions stimulate these kinases, especially c-jun-N-terminal kinase (JNK(1)/SAPK(1)), reveal a potential role JNK(1)/SAPK(1) in control hepatocyte...
The natural compound ravenelin was isolated from the biomass extracts of Exserohilum rostratum fungus, and its antimicrobial, antiplasmodial, trypanocidal activities were evaluated. Ravenelin by column chromatography HPLC identified NMR MS. susceptibility Gram-positive Gram-negative bacteria strains to determined microbroth dilution assay. Cytotoxicity evaluated in hepatocarcinoma cells (HepG2) BALB/c peritoneal macrophages using MTT. SYBR Green I-based assay used asexual stages Plasmodium...
Artemisinin-based combination therapy (ACT) is used as the first-line treatment of uncomplicated malaria caused by Plasmodium falciparum parasite and chloroquine-resistant vivax parasites. Evidence resistance to ACT has been reported in Cambodia, without new effective anti-malarial agents, burden mortality will rise.The MolPrint 2D fingerprints Tanimoto similarity index were perform a structural search within Malaria Box collection select diverse molecular scaffolds that are different from...
We describe herein the design and synthesis of N-phenyl phthalimide derivatives with inhibitory activities against Plasmodium falciparum (sensitive resistant strains) in low micromolar range noticeable selectivity indices human cells. The best inhibitor, 4-amino-2-(4-methoxyphenyl)isoindoline-1,3-dione (10), showed a slow-acting mechanism similar to that atovaquone. Enzymatic assay indicated 10 inhibited P. cytochrome bc1 complex. Molecular docking studies suggested binding mode hit Qo site...
The Zika virus (ZIKV) is a neurotropic arbovirus considered global threat to public health. Although there have been several efforts in drug discovery projects for ZIKV recent years, are still no antiviral drugs approved date. Here, we describe the results of collaborative crowdsourced open science project, OpenZika from IBM's World Community Grid (WCG), which integrates different computational and experimental strategies advancing candidate ZIKV. Initially, molecular docking protocols were...
4(1H)-quinolone is an attractive template for antimalarial drug discovery campaigns. Given the current global increase in and insecticide resistance, of new drugs urgent goal fight against malaria. Here, synthesis antiplasmodial profiling a series derivatives are reported. Four compounds showed inhibitory activities submicromolar range panel sensitive resistant Plasmodium falciparum strains (IC50s = 0.07–0.48 μM) neither cytotoxic (SI > 210) nor hemolytic were observed. Representative...
Interleukin (IL)-8 induces fever in rats by a mechanism independent of the release cyclooxygenase products. The purpose this study was to investigate whether similar is responsible for pyrogenic effect IL-8 rabbits. Intravenous (0.31-5.0 ng/kg) or intracerebroventricular (15.6-250 pg) injections induced dose-dependent increase body temperature. correlations between doses recombinant human and index were 0.98 0.99 intravenous injections, respectively. activity not due contamination with...
Malaria is an infectious disease caused by protozoan parasites of the genus Plasmodium and transmitted Anopheles spp. mosquitos. Due to emerging resistance currently available drugs, great efforts must be invested in discovering new molecular targets drugs. N-myristoyltransferase (NMT) essential enzyme has been validated as a chemically tractable target for discovery drug candidates against malaria. In this work, 2D 3D quantitative structure-activity relationship (QSAR) studies were...
Malaria is an infectious illness, affecting vulnerable populations in Third World countries. Inspired by natural products, indole alkaloids have been used as a nucleus to design new antimalarial drugs. So, eighteen oxindole derivatives, aza analogues were obtained with moderate excellent yields. Also, the saturated derivatives of and via H2/Pd/C reduction good yields, leading racemic mixtures each compound. Next, inhibitory activity against P. falciparum 18 compounds tested, founding six...
An important application in Smart Grids is the Advanced Metering Infrastructure (AMI). Under AMI, utilities use smart meters and aggregators to collect consumer data that support better-informed automated decisions. AMIs are typically formed by wireless links, reducing investments infrastructure. Although beneficial, of raise issues reliability coverage, requires estimation success rate delivering packages. This paper discusses Extended Hata-SRD propagation model urban, suburban rural...
The aim of this study is to analyze the design and use Balanced Scorecard in a shared services center (SSC).A case was conducted SSC that uses (BSC) their performance management process.The framework proposed by Ferreira Otley used for data collection order visualize possible adaptations original BSC model SSC, according peculiarities units constituting it.The results indicate prevailing characteristics such as structure, strategy, indicators directed at optimizing processes through cost...
Summary Shear velocity and density logs are key data for reservoir characterization, yet their acquisition is not always guaranteed. Common industry practices to overcome the lack of present in interested wells based on empirical models have limitations related different geological facies. This work an application machine learning predict shear using gamma ray, resistivity porosities as inputs. The case study a dataset from carbonate reservoirs Buzios pre-salt, Santos Basin, Brazil. applied...
Projetos básicos (PB) de convênios com tempo aprovação elevado acarretam na diminuição da eficiência execução do objeto. Este trabalho apresenta um estudo caso, a discussão dos resultados aplicação metodologia gerenciamento processo projeto em obras públicas pequeno porte, que utilizou como referência o guia PMBOK®, procedimento adaptação 03 estágios e princípios pensamento enxuto, foco redução consequentemente no vigência total. A foi aplicada à etapa PB 06 acompanhados por Instituição...
Introdução: As fraturas de fêmur no Brasil são frequentes na população idosa. Isso está ligado diretamente ao processo envelhecimento populacional e afeta a qualidade vida do indivíduo, como perda autonomia, dependência funcional problemas ordem social econômica. A fisioterapia pós-operatório fratura é extrema importância necessária para esses pacientes reaprenderem coordenar seu equilíbrio estático, dinâmico postural, transferência peso durante deambulação, iniciando assim o ciclo da marcha...