A5020852044- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Bioactive Compounds and Antitumor Agents
- Computational Drug Discovery Methods
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Fungal Plant Pathogen Control
- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Bioactive natural compounds
- Morinda citrifolia extract uses
- Crystallization and Solubility Studies
- Phytochemicals and Medicinal Plants
- 14-3-3 protein interactions
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Sesquiterpenes and Asteraceae Studies
- Garlic and Onion Studies
- Seaweed-derived Bioactive Compounds
- Genomics, phytochemicals, and oxidative stress
- Molecular Sensors and Ion Detection
- Electrochemical sensors and biosensors
- Free Radicals and Antioxidants
- Biochemical and biochemical processes
- Polysaccharides and Plant Cell Walls
Universidad Central de Chile
2022-2024
Pontificia Universidad Católica de Valparaíso
2017-2022
Federico Santa María Technical University
2012-2017
University of Valparaíso
2014-2017
Metabolism and Renal Physiology
1988
In this study, a series of novel 1,3,4-oxadiazole-benzimidazole derivatives were designed and synthesized. Their cytotoxic activities against five cancer cell lines, including A549, MCF-7, C6, HepG2, HeLa, evaluated by the MTT assay. The compounds 5b,c showed satisfactory potencies with much higher anticancer activity in comparison to reference drug doxorubicin studied lines. vitro, enzymatic inhibition assays aromatase (ARO) enzymes performed. Molecular docking, molecular dynamics...
Monoamine oxidases (MAOs) are attractive targets in drug design. The inhibition of one the isoforms (A or B) is responsible for modulating levels different neurotransmitters central nervous system, as well production reactive oxygen species. Molecules that act selectively on MAO have been studied deeply, and coumarin has described a promising scaffold. In current manuscript we describe comparative study between 3-phenylcoumarin (endo coumarin-resveratrol-inspired hybrid)...
Ephedra chilensis K Presl, known locally as pingo-pingo, is a Chilean endemic plant used in traditional medicine an anti-inflammatory and other treatments. However, unlike for the species, there have been no reports on antioxidant cytotoxic effects of this plant. The present study aims to explore potential applications E. extract agent against vitro cancer cell lines relationship between activity.Total anthraquinone, flavonoid, phenolic contents, well activity (DPPH, FRAP, TRAP assays)...
Three anthraquinones, the well known emodin (3) and physcion (6) new anthraquinone glycoside emodin-8-β-D-idopyranoside (7) were isolated from leaves of Muehlenbeckia hastulata.The antioxidant activity these compounds was measured using DPPH assay; all three showed weaker than gallic acid.
Glycogen synthase kinase 3 (GSK-3) is involved in different diseases, such as manic-depressive illness, Alzheimer's disease and cancer. Studies have shown that insulin inhibits GSK-3 to keep glycogen active. Inhibiting may an indirect pro-insulin effect by favouring synthesis. Therefore, the development of inhibitors can be a useful alternative for treatment type II diabetes. Aminopyrimidine derivatives already proved interesting inhibitors. In current study, comparative molecular field...
Abstract Different natural and synthetic chalcones have exhibited selective inhibition on monoamine oxidase B (MAO−B) activity, demonstrating potential interest for the treatment of neurodegenerative diseases. Herein we report synthesis seven new prenylated (7a‐g) obtained from compound 5 (4‐hydroxy‐3‐(3‐methylbut‐2‐en‐1‐yl)phenylethanone), previously isolated S. graveolens . Five these compounds exhibit high selectivity against MAO−B, with IC 50 values in low micromolar range. In addition,...
Abstract Background Standard cancer treatments show a lack of selectivity that has led to the search for new strategies against cancer. The selective elimination cells modulating redox environment, known as “selective oxycution”, emerged viable alternative. This research focuses on characterizing unexplored Escallonia genus plant extracts and evaluating their potential effects cancer’s balance, cytotoxicity, activation death pathways. Methods 36 were obtained from 4 different species ( E....
This study aimed to determine the in vitro cytotoxicity and understand possible cytotoxic mechanisms via an silico of eleven chalcones synthesized from two acetophenones. Five were a prenylacetophenone isolated plant that grows Andean region Atacama Desert. The activity all was tested against breast cancer cell lines using MTT proliferation assay. results suggest prenyl group A-ring methoxy hydroxyl substituents B-ring appear be crucial for these compounds. 12 13 showed significant...
This study evaluates the content of polyphenols, flavonoids and anthraquinones from sequential extracts four algae species along Chilean coastline: Desmarestia ligulata , Dictyota kunthii Laurencia chilensis Chondracanthus chamissoi . The antioxidant capacity these was evaluated through three complementary assays: TRAP, FRAP, DPPH assays. Additionally, cytotoxic activity determined sulforhodamine B assays on two cancer cell lines, one colon (HT-29) breast (MCF-7), non-tumor control group...
Abstract BACKGROUND The antifeedant activity of 18 sesquiterpenoids the drimane family (polygodial, drimenol and derivatives) was investigated. RESULTS Polygodial, drimanic nordrimanic derivatives were found to exert effects against two insect species, Spodoptera frugiperda Epilachna paenulata , which are pests agronomic interest, indicating that they have potential as biopesticide agents. Among compounds tested, epoxynordrimane compound ( 11 ) isonordrimenone 4 showed highest [50% effective...
Acanthus mollis is used as ornamental and medicinal plant. The ethnopharmacology reports indicate that extracts have anti-inflammatory activity. Phytoconstituents profile was evaluated by estimating the content of anthraquinones, flavonoids phenols. In addition, antioxidant activity using four methods: Hydrogen atoms transfer (TRAP, ORAC DPPH assays), single electron (FRAP assay). Finally, antifungal determined M27-A2 test. results shown ethanol highest concentration phenols, anthraquinones...
This work reports on the synthesis of eight new 2'-hydroxy-chalcones with potential anti-phytopathogenic applications in agroindustry, among others, via Claisen-Schmidt condensation and ultrasound assisted reaction. Assays showed three chalcones allyl moieties strongly inhibited growth phytopathogenic oomycete Phytophthora infestans; moreover, compound 8a had a half maximal effective concentration (EC50) value (32.5 µg/mL) similar to that metalaxyl (28.6 µg/mL). A software-aided quantitative...
A non-structural SARS-CoV-2 protein, PLpro, is involved in post-translational modifications cells, allowing the evasion of antiviral immune response mechanisms. In this study, potential PLpro inhibitory drugs were designed using QSAR, molecular docking, and dynamics. combined QSAR equation with physicochemical Free-Wilson descriptors was formulated. The r2, q2, r2test values 0.833, 0.770, 0.721, respectively. From equation, it found that presence an aromatic ring a basic nitrogen atom...
Malaria is an infectious disease caused by Plasmodium spp. parasites, with widespread drug resistance to most antimalarial drugs. We report the development of two 3D-QSAR models based on comparative molecular field analysis (CoMFA), similarity index (CoMSIA), and a 2D-QSAR model, using database 349 compounds activity against P. falciparum 3D7 strain. The were validated internally externally, complying all metrics (q2 > 0.5, r2test 0.6, r2m etc.). final have shown following statistical...
To investigate the anti-Saprolegnia activities of chalconic compounds, nine dialkoxychalcones 2⁻10, along with their key building block 2',4'-dihydroxychalcone 1, were evaluated for potential oomycide against Saprolegnia australis strains. The synthesis afforded a series O-alkylated derivatives typical chalcone skeletons. Compounds 4⁻10 reported first time. Interestingly, analogue 8 new scaffold demonstrated remarkable in vitro growth-inhibitory strains, displaying greater anti-oomycete...
The β3 adrenergic receptor is raising as an important drug target for the treatment of pathologies such diabetes, obesity, depression, and cardiac diseases among others. Several attempts to obtain selective high affinity ligands have been made. Currently, Mirabegron only available on market that targets this approved overactive bladder. However, FDA (Food Drug Administration) in USA MHRA (Medicines Healthcare products Regulatory Agency) UK made reports potentially life-threatening side...
Abstract The aim of this study was to evaluate the influence phenolic, flavonoid, and anthraquinones from sequential extracts (n-hexane, dichloromethane, ethyl acetate, ethanol) Embothrium coccineum leaves on antioxidant capacity, cell viability, toxicity same, in order find possible sources for novel antioxidants food pharmaceutical formulations. Antioxidant potential analyzed by five different assays: 2,2-diphenyl-1- picrylhydrazyl radical scavenging activity assay (DPPH), hydrogen...
Nowadays, antimicrobial resistance is a serious concern associated with the reduced efficacy of traditional antibiotics and an increased health burden worldwide. In response to this challenge, scientific community developing new generation antibacterial molecules. Contributing effort, inspired by resveratrol structure, five resveratrol-dimers (9a−9e) one resveratrol-monomer (10a) were synthetized using 2,5-dibromo-1,4-diaminobenzene (8) as core compound for Schiff base bridge conformation....