A5020521583- Adipose Tissue and Metabolism
- Molecular Biology Techniques and Applications
- Drug-Induced Hepatotoxicity and Protection
- Biopolymer Synthesis and Applications
- Natural Antidiabetic Agents Studies
- Cancer, Hypoxia, and Metabolism
- Pharmacogenetics and Drug Metabolism
- Sirtuins and Resveratrol in Medicine
- Genomics, phytochemicals, and oxidative stress
- Tea Polyphenols and Effects
- Cancer Research and Treatments
- Food Quality and Safety Studies
- Animal Genetics and Reproduction
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Immunotoxicology and immune responses
- Diversity and Career in Medicine
- Peroxisome Proliferator-Activated Receptors
- Carcinogens and Genotoxicity Assessment
- Heavy Metal Exposure and Toxicity
- Ginger and Zingiberaceae research
- Advances in Cucurbitaceae Research
- Medical Education and Admissions
- Cassava research and cyanide
- Bioactive Compounds and Antitumor Agents
University of Valparaíso
2024
Jackson State University
2002-2023
Center for Environmental Health
2012
Breast Cancer Research Foundation
2012
Andrew W. Mellon Foundation
2003
Harvard University
2003
Purpose Many U.S. medical schools have abandoned affirmative action, limiting the recruitment and reducing admission of underrepresented minority (URM) students even though research supports premise that public benefits from an increase in URM physicians are likely to serve minority, poor, Medicaid populations. Faculty commonly assume they benefit peer cultural exchange, published evidence for past two decades this notion. This examined students' perceptions educational merits a diverse...
The initiation and progression of breast cancer is a complex process that influenced by heterogeneous cell populations within the tumor microenvironment. Although adipocytes have been shown to promote development, adipocyte characteristics involved in this remain poorly understood. In study, we demonstrate enrichment beige/brown adipose markers, contributed from host as well cells, xenografts lines. addition uncoupling protein-1 (UCP1) exclusively expressed adipocytes, gene expression for...
Lead exposure represents a medical and public health emergency, especially in children consuming high amounts of lead-contaminated flake paints. It may also cause hematological effects to people all ages. Recent studies our laboratory have indicated that apoptosis be associated with the lead-induced oxidative stress DNA damage. However, mechanisms underlying its effect on lymphocytes are still largely unknown. Therefore, aim present study was investigate apoptotic lead nitrate [Pb(NO3)2]...
The role of ethanol or its metabolites on breast neoplasm has not been characterized. We hypothesized that may alter the growth rate human tumor epithelial cells by modulating putative growth-promoting signaling pathways such as p44/42 mitogen-activated protein kinases (MAPKs). MCF-7 cell line, considered a suitable model, was used in these studies to investigate effects [(3)H]thymidine incorporation, number, and MAPK activities presence absence extracellular signal-regulated kinase ERK-1,...
Abstract Background Standard cancer treatments show a lack of selectivity that has led to the search for new strategies against cancer. The selective elimination cells modulating redox environment, known as “selective oxycution”, emerged viable alternative. This research focuses on characterizing unexplored Escallonia genus plant extracts and evaluating their potential effects cancer’s balance, cytotoxicity, activation death pathways. Methods 36 were obtained from 4 different species ( E....
INTRODUCTION: Acute promyelocytic leukemia (APL) is a malignant disorder of the white blood cells. Arsenic trioxide (As(2)O(3)) has been used as therapeutic agent to treat APL and other tumors. Studies suggest that ascorbic acid (AA) supplementation may improve clinical outcome As(2)O(3) for patients. Our aim was use human (HL-60) APL-cells an in vitro test model evaluate effect physiologic doses AA on As(2)O(3)-induced toxicity apoptosis HL-60 METHODS: cells were treated either with...
Abstract: Innovative developments are necessary for treating and defeating cancer, an oftentimes deadly group of diseases characterized by the uncontrolled growth spread abnormal cells. Breast cancer (BC) is second leading cause cancer-related deaths women in USA, prostate (PC) American men. Although some efficacious BC drugs pharmaceutically marketed, they affect quality life patients because toxic that their usages have been accompanied side effects such as stroke, thrombosis, slow heart...
Ultraviolet (UV)-induced cataracts are becoming a major environmental health concern because of the possible decrease in stratospheric ozone layer. Experiments were designed to isolate gene(s) affected by UV irradiation rabbit cornea tissues using fluorescent differential display-reverse transcription-polymerase chain reaction (FDDRT-PCR). The epithelial cells grown standard medium for 2 or 4 hours post treatment. Cornea irradiated with UVB 20 minutes. RNA was extracted and amplified reverse...
Negative health impacts exist for individuals who identify as lesbian, gay, bisexual, transgender, or something other than heterosexual are critical. Nurses on the front lines of delivering holistic patient care to everyone, and their potential biases regarding this vulnerable population may negatively affect care. The study used scores from two tests designed measure implicit bias in towards sexual gender minorities (SGM). A retrospective design with secondary data Project Implicit was...
Abstract Breast cancer (BC), a major public health problem, is one of the leading causes cancer-related deaths among women. In particular, triple-negative breast (TNBC), most aggressive form BC poses significant therapeutic challenges. TNBCs are common in women with BRCA1 gene mutations, younger women, and pre-menopausal African American (AA) compared to White significantly contributing disparities. Consisting many heterogeneous, undifferentiated cell types including very high mammary stem...
<p>Images of xenografts, osmium stained sections, quantitation lipids and immunohistochemistry.</p>
<p>Human breast tumors used in this study were according to the stage/grade</p>
<p>Human breast tumor tissues were characterized based on ethnicity and age</p>
<p>Sections of xenografts were analyzed for co-expression collagen and adiponectin.</p>
<p>Upregulation of the markers beige/brown adipocytes were not dependent on site cancer cell injection.</p>
<p>Sequence of various mouse and human primers used in this study.</p>
<p>Human specific and mouse primers were validated using human pheochromocytoma-derived peri-adrenal fat brown adipose tissue respectively.</p>
<div>Abstract<p>The initiation and progression of breast cancer is a complex process that influenced by heterogeneous cell populations within the tumor microenvironment. Although adipocytes have been shown to promote development, adipocyte characteristics involved in this remain poorly understood. In study, we demonstrate enrichment beige/brown adipose markers, contributed from host as well cells, xenografts lines. addition uncoupling protein-1 (UCP1) exclusively expressed...
<div>Abstract<p>The initiation and progression of breast cancer is a complex process that influenced by heterogeneous cell populations within the tumor microenvironment. Although adipocytes have been shown to promote development, adipocyte characteristics involved in this remain poorly understood. In study, we demonstrate enrichment beige/brown adipose markers, contributed from host as well cells, xenografts lines. addition uncoupling protein-1 (UCP1) exclusively expressed...
<p>Human specific and mouse primers were validated using human pheochromocytoma-derived peri-adrenal fat brown adipose tissue respectively.</p>
<p>Upregulation of the markers beige/brown adipocytes were not dependent on site cancer cell injection.</p>
<p>Sections of xenografts were analyzed for co-expression collagen and adiponectin.</p>