A5060247565- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Phenothiazines and Benzothiazines Synthesis and Activities
- Click Chemistry and Applications
- Enzyme function and inhibition
- Multicomponent Synthesis of Heterocycles
- Antifungal resistance and susceptibility
- Fungal Plant Pathogen Control
- Synthesis of Tetrazole Derivatives
- Bioactive Compounds and Antitumor Agents
- Quinazolinone synthesis and applications
- Inflammatory mediators and NSAID effects
- Synthesis and Catalytic Reactions
- Cancer therapeutics and mechanisms
- Synthesis of heterocyclic compounds
- Synthesis and Reactions of Organic Compounds
- Estrogen and related hormone effects
- Chemical synthesis and alkaloids
- Chemical Reactions and Mechanisms
- Electrochemical sensors and biosensors
- Chemical synthesis and pharmacological studies
- Synthesis of Organic Compounds
Anadolu University
2016-2025
Eskişehir City Hospital
2016-2025
Usak University
2025
Bilecik University
2025
Bülent Ecevit University
2017
Atatürk University
2017
Al-Azhar University – Gaza
2016
Marmara University
2016
RMIT University
2014
Abstract Carbonic anhydrase (CA) enzymes are involved in many physiological events. These enzymes, which contain Zn 2+ their structure, can be easily inhibited by dithiocarbamate compounds. In addition, CA enzyme inhibitory activities known groups such as sulfonamide and methylsulfonyl. For this purpose, study, a series of 23 new dithiocarbamate‐methylsulfonyl derivatives were synthesized investigated. The inhibition potentials the obtained compounds against human I II investigated vitro...
Breast cancer is the most frequent female and second cause of cancer-related deaths among women around world. Two thirds breast patients have hormone-dependent tumors, which very likely be treated with hormonal therapy. Aromatase involved in biosynthesis estrogen thus a critical target for cancer. In this study, order to identify new aromatase enzyme inhibitors, series benzimidazole-1,3,4-oxadiazole derivatives were synthesized characterized by 1H NMR, 13C MS spectra analyses. vitro...
Invasive fungal infections (IFIs) are increasing as major infectious diseases around the world, and limited efficacy of existing medications has resulted in substantial morbidity death patients due to lack effective antifungal agents serious drug resistance. In this study, a series benzimidazole-1,2,4-triazole derivatives (6a-6l) were synthesized characterized by 1H NMR, 13C HR-MS spectral analysis. All target compounds screened for their vitro activity against four strains, namely, C....
This study focused on the design, synthesis, chemical characterization, and potential inhibitory of thiazole-methylsulfonyl derivatives against carbonic anhydrase enzymes. The synthesized compounds, with characteristics both thiazole ring methyl sulfonyl group, were through a two-step scheme, their structures confirmed NMR spectroscopy HRMS. Additionally, structure compound 2b was elucidated by an X-ray study. An enzyme inhibition assay performed to assess biological activity anhydrases,...
During the last five decades, a large number of BT (Benzothiazole) derivatives formed one eligible structures in medicinal chemistry as anticancer agents. Most studies reveal that various substitutions at specific positions on scaffold modulate antitumor property. The potential BTs encouraged us to synthesize new 2-((5-substitutedbenzothiazol-2-yl)thio)-N’-(2-(4-(substitutedphenyl)ethylidene)acetohydrazide and investigate their probable activity. 4-Substitued benzaldehyde (1a⁻1e) were...
In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2a–s were synthesized and evaluated for their antidepressant-like activity by tail suspension test (TST) modified forced swimming (MFST). The effects of the compounds on spontaneous locomotor also investigated using cage apparatus. Among these derivatives, 2b, 2d, 2f, 2o, 2r decreased both horizontal vertical number mice. On other hand, 2a, 2h, 2j, 2k, 2l, 2m, 2n, which did not induce any significant change in...
In an attempt to develop potent antitumor agents, new 1,3,4-thiadiazole derivatives were synthesized and evaluated for their cytotoxic effects on multiple human cancer cell lines, including the K562 chronic myelogenous leukemia line that expresses Bcr-Abl tyrosine kinase. N-(5-Nitrothiazol-2-yl)-2-((5-((4-(trifluoromethyl)phenyl)amino)-1,3,4-thiadiazol-2-yl)thio)acetamide (2) inhibited Abl protein kinase with IC50 value of 7.4 µM showed selective activity against positive line. Furthermore,...
Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with progression of this multifactorial weakening cholinergic system in brain. Cholinesterase (ChE) inhibitors are recognized as one choices treatment AD. inhibition acetylcholinesterase (AChE) butyrylcholinesterase (BChE) were approved therapeutic strategy reduce symptoms AD prevent its progression. capacity BChE not completely...