A5074136342- Synthesis and biological activity
- Cholinesterase and Neurodegenerative Diseases
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Enzyme function and inhibition
- Cancer therapeutics and mechanisms
- Chemical synthesis and alkaloids
- Electrochemical sensors and biosensors
- Phenothiazines and Benzothiazines Synthesis and Activities
- Inflammatory mediators and NSAID effects
- Antifungal resistance and susceptibility
- Estrogen and related hormone effects
- Bioactive Compounds and Antitumor Agents
- Synthesis of heterocyclic compounds
- Quinazolinone synthesis and applications
- Fungal Plant Pathogen Control
- Medicinal Plants and Neuroprotection
- Sulfur-Based Synthesis Techniques
- X-ray Diffraction in Crystallography
- Phytochemical compounds biological activities
- Synthesis of Organic Compounds
- Synthesis and Catalytic Reactions
- Metal complexes synthesis and properties
Anadolu University
2016-2025
Eskişehir City Hospital
2016-2025
Usak University
2016
Eskişehir Osmangazi University
2016
Sorafenib, a multiple kinase inhibitor, is widely used as first-line treatment for hepatocellular carcinoma. However, there need more effective alternatives when sorafenib proves insufficient. In this study, we aimed to design structure that surpasses sorafenib's efficacy, leading us synthesize sorafenib–ruthenium complexes the first time and investigate their properties. Our results indicate exhibit superior epidermal growth factor receptor (EGFR) inhibition compared alone. Interestingly,...
Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly, and causes death due to dementia. The main pathogenic feature connected with progression of this multifactorial weakening cholinergic system in brain. Cholinesterase (ChE) inhibitors are recognized as one choices treatment AD. inhibition acetylcholinesterase (AChE) butyrylcholinesterase (BChE) were approved therapeutic strategy reduce symptoms AD prevent its progression. capacity BChE not completely...
Discovery of novel anticandidal agents with clarified mechanisms action, could be a rationalist approach against diverse pathogenic fungal strains due to the rise resistance existing drugs. In support this hypothesis, in paper, series benzimidazole-oxadiazole compounds were synthesized and subjected antifungal activity evaluation. vitro assays indicated that some exhibited moderate potent activities tested Candida species when compared positive control amphotericin B ketoconazole. The most...
Lung cancer is one of the most common types with highest mortality rates. However, while epidermal growth factor receptor (EGFR) an important parameter for lung cancer, EGFR inhibitors also show great promise in treatment disease. Therefore, a series new inhibitor candidates containing thiadiazole and pyrazole rings have been developed. The activities synthesized compounds were elucidated by vitro MTT, (which chemically 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide),...
In this study, we designed, synthesized, and evaluated a series of 1,2,4-triazole benzimidazoles for their cytotoxic effects against the A549, C6, NIH3T3 cell lines. Additionally, these compounds were assessed inhibitory activity DNA topoisomerase I, aiming to develop novel anticancer agents. The synthesized final
In the present work, 14 new 1-substituted-2-phenylhydrazone derivatives were synthesized to evaluate their inhibitory activity against hMAO enzymes. The structures of newly hydrazones 2a–2n characterized by IR, 1H-NMR, 13C-NMR, HR-MS spectroscopic methods. compounds hMAO-A and hMAO-B enzymes was elucidated using an in-vitro Amplex Red® reagent assay based on fluorometric According studies, 2a 2b found be most active enzyme, with IC50 values 0.342 µM 0.028 µM, respectively. 2a–2b evaluated...
Due to anticandidal importance of azole compounds, a new series benzimidazole-triazole derivatives (5a–5s) were designed and synthesized as ergosterol inhibitors. The chemical structures the target compounds characterized by spectroscopic methods. final screened for antifungal activity against Candida glabrata (ATCC 90030), krusei 6258), parapsilosis 22019), albicans 24433). Compounds 5i 5s exhibited significant inhibitory strains with MIC 50 values ranging from 0.78 1.56 μ g/mL....
Owing to the growing need for antifungal agents, we synthesized a new series 2-((5-(4-(5-substituted-1H-benzimidazol-2-yl)phenyl)-4-substituted-4H-1,2,4-triazol-3-yl)thio)-1-(substitutedphenyl)ethan-1-one derivatives, which were tested against Candida species. The compounds characterized and elucidated by FT-IR, 1H-NMR, 13C-NMR HR-MS spectroscopies. screened in vitro anticandidal activity species broth microdiluation methods. In cytotoxic effects of final determined MTT assay....
Alzheimer's disease (AD), one of the main causes aged dementia, is a progressive and degenerative neurological disorder characterized by loss cognition memory. Although symptomatic treatment AD, particularly acetylcholinesterase inhibitors (AChEIs) based on 'cholinergic hypothesis', has been successful in clinic, at present there no cure for this disease. In study, we designed compounds carrying benzimidazole triazole rings same chemical skeleton so as to investigate their potential...
The use of dual acetylcholinesterase (AChE)-monoamine oxidase B (MAO-B) inhibitors is a new approach in the treatment Alzheimer disease (AD). In this work, 14 benzothiazoles (4a-4n) were designed and synthesized. biological activity studies, AChE, butyrylcholinesterase (BChE), MAO-A MAO-B inhibitory potentials all compounds evaluated using
Uncontrolled use of antifungal drugs affects the development resistance to existing drugs. Azole antifungals constitute a large part therapy. Therefore, there is need for new azole antifungals. Within scope this study, 17 triazole derivative compounds were synthesized. Structure determinations clarified by spectroscopic analysis methods (1H-NMR, 13C-NMR, HRMS). In addition, structure matching was completed using two-dimensional NMR techniques, HSQC, HMBC and NOESY. The effects evaluated on...
Cancer is a progressive disease that frequently encountered worldwide. The incidence of cancer increasing with the changing living conditions around world. side-effect profile existing drugs and resistance developing in long-term use increase need for novel drugs. In addition, patients are not resistant to bacterial fungal infections due suppression immune system during treatment. Rather than adding new antibacterial or antifungal drug current treatment plan, fact anticancer activity has...
With the goal of obtaining a novel bioactive compound with significant antifungal activity, series 1,3,4-thiadiazole derivatives (3a⁻3l) were synthesized and characterized. Due to thione-thiol tautomerism in intermediate 2, type substitution reaction final step was determined by two-dimensional (2D) NMR. In vitro activity compounds evaluated against eight Candida species. The active 3k 3l displayed very notable effects. probable mechanisms action investigated using an ergosterol...
Alzheimer's disease (AD) is the most common of degenerative brain diseases and described together with impairment cognitive function. Patients AD lose capability to code new memories, life conditions are extremely difficult. The development drugs in this area continues at a great pace. A novel series thiazole-piperazine hybrids, aimed against (AD), have been synthesized. structure identification synthesized compounds was elucidated by 1HNMR, 13C-NMR, LCMSMS spectroscopic methods. inhibitory...