A5070419138- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Insect Pest Control Strategies
- Synthesis and Biological Evaluation
- Enzyme function and inhibition
- Fungal Plant Pathogen Control
- Multicomponent Synthesis of Heterocycles
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cancer therapeutics and mechanisms
- Synthesis of heterocyclic compounds
- PARP inhibition in cancer therapy
- Electrochemical sensors and biosensors
- Quinazolinone synthesis and applications
- Mosquito-borne diseases and control
- Synthesis of Tetrazole Derivatives
- Insect and Pesticide Research
- Synthesis and Reactions of Organic Compounds
- Insect behavior and control techniques
- Histone Deacetylase Inhibitors Research
- Science Education and Perceptions
- Coordination Chemistry and Organometallics
- Synthesis and Catalytic Reactions
- Microbial Applications in Construction Materials
Biruni University
2024-2025
Marmara University
2013-2023
Atatürk University
2016
Ağrı İbrahim Çeçen University
2016
Synthesis of chalcones (1,3-diarylprop-2-en-1-ones) and 2-pyrazoline derivatives has been an active field research due to their established pharmacological effects. In this study, a series were prepared with methyl aryl ketones substituted aldehydes in the presence sodium hydroxide methanol through Claisen-Schmidt condensation. 3,5-Disubstituted-4,5-dihydro-1H-pyrazole-1-carbothioamides synthesized by refluxing selected thiosemicarbazide alkaline medium. Similarly...
A series of novel thiourea and urea derivatives containing 1,2,4-triazole moieties were synthesized evaluated for their antifungal larvicidal activity. Triazole 3a–e 4a–e by reacting thiocarbohydrazide with compounds 1a–e 2a–e, respectively, in a 130–140 °C oil bath. The proposed structures all the confirmed using elemental analysis, UV, IR, 1H-NMR mass spectroscopy. All activity against plant pathogens, biting deterrent mosquito Aedes aegypti L. vitro cytotoxicity anti-inflammatory some...
Despite the efforts to treat cancer with chemotherapeutic agents targeting different mechanisms, is still one of most important health problems today. The increase in incidence has led researchers discover new, effective, and selective molecules. For this purpose, novel thiosemicarbazide (3a–3i) 1,3,4-thiadiazole derivatives (4a–4i) were synthesized from clopidogrel bisulfate their cytotoxic activities investigated against glioblastoma (U87) cell line healthy fibroblast (L929) by MTT assay....
Abstract Background Taking into account the improvement in insecticidal activity by inclusion of fluorine hydrazone moiety, authors synthesized new 4‐fluorobenzoic acid hydrazides and 3‐acetyl‐2,5‐disubstituted‐2,3‐dihydro‐1,3,4‐oxadiazoles, substituting a phenyl group or heteroaryl ring carrying one two atoms F, Cl Br, investigated their biting deterrent larvicidal activities against Aedes aegypti for first time. Results The compound...
A series of 1-(2-hydroxyethyl)-3,5-dimethylpyrazolylazo derivatives, incorporating thiosemicarbazide 2a-c, 1,3,4-thiadiazole 3a-c, and 1,2,4-triazole-3-thione 4a-c were synthesized. The structure these novel synthesized compounds was confirmed by spectral analysis. All screened for their analgesic activity. Hot-plate tail-immersion tests used the determination Morphine, an through both spinal supraspinal pathways, as a standard test drug. administered at dose 100 mg/kg i.p. Among compounds,...
GRAPHICAL ABSTRACTSynthesis, anticancer activity and ADMET studies of N-(5-methyl-1,3,4-thiadiazol-2-yl)-4-[(3-substituted)ureido/thioureido] benzenesulfonamide derivativesAll authorsS. Karakuş, F. Tok, S. Türk, E. Salva, G. Tatar, T. Taskın-Tok & B. Kocyigit-Kaymakcıogluhttps://doi.org/10.1080/10426507.2018.1452924Published online:11 April 2018
1,3,4-Oxadiazole and imidazolidine rings are important heterocyclic compounds exhibiting a variety of biological activities. In this study, novel with oxadiazole were synthesized from 3-(methylsulfonyl)-2-oxoimidazolidine-1-carbonyl chloride screened for insecticidal The proposed structures the 17 confirmed using elemental analysis, infrared (IR), proton nuclear magnetic resonance (
Abstract In this present study, new chalcone derivatives were synthesized from 4-aminoacetophenone, which confirmed by spectroscopic methods. The toxic risks of chalcones to humans and the environment investigated a web-based platform called ADMETlab. With program, possible effects compounds on liver, respiratory system, eyes evaluated. For topical insecticidal activity, adult female Caribbean fruit fly, Anastrepha suspensa , was targeted. Results toxicity tests showed that are effective...
A series of novel thiourea derivatives carrying the 5-cylohexylamino-1,3,4-thiadiazole moiety was synthesized and their anticonvulsant activity evaluated. Structures compounds have been confirmed by IR, 1H-NMR, elemental analysis. All were administered at a dose 50 mg/kg. Some active different effects in pentylenetetrazole (PTZ) maximal electroshock (MES) tests, indicating therapeutical potential petit mal seizures, but not grand seizures. Compounds 10, 11, 13, 14 2-methylphenyl,...
Background: Hydrazones, one of the important classes organic molecules, are pharmaceutical agents comprising –CO-NH-N=CH- group in structure therefore and exhibiting significant biological activity. Methods: 5-Chloro-N’-[(substituted)methylidene] pyrazine-2-carbohydrazide (3a-g) their Pd(II) complexes (4a-h) were synthesized investigated vitro anticancer activity on A549, Caco2 cancer normal 3T3 fibroblast cell lines, using MTT assay. Results: Anticancer screening results revealed that some...
Novel thiosemicarbazone derivatives were synthesized via condensation reactions between the corresponding thiosemicarbazides and 4-(methylsulfonyl)acetophenone. The chemical structures of all compounds elucidated by infrared (IR), 1H-NMR 13C-NMR spectroscopy mass spectrometry. Antioxidant studies performed using CUPRAC, FRAP, DPPH methods. 2-{1-[4-(Methylsulfonyl)phenyl]ethylidene}-N-phenylhydrazinecarbothioamide (1) possessed good antioxidant activity with an SC50 value 15.70 µM which also...
Abstract: Pyrazoles are well-known five-membered heterocyclic compounds and found in a wide variety of synthetic natural compounds. Compounds carrying pyrazole scaffolds exhibit range biological activities such as anticancer, antimicrobial, anticonvulsant, antioxidant, analgesic anti-inflammatory effects. Pharmaceuticals with many different the structure currently on market (e.g., celecoxib, lonazolac, tepoxalin, rimonabant, pyrazofurin, epirizole). The ring contains N-N double bond, which...
Novel pyrazoline derivatives containing benzo[d]thiazol-2(3H)-one moiety were synthesized and screened for their inhibitory properties against urease, a clinically important metabolic enzyme. In vitro enzyme inhibition studies revealed that all pyrazolines (7.21-87.77 μM) more potent than the standard inhibitor acetohydroxamic acid (251.74 urease Most notably, compound 2m, which is active other compounds in molecular docking studies, showed significant potential efficient IC50 values...
In this study, thirteen phthalimide derivatives were designed and synthesized. All synthesized compounds evaluated to determine their potential for inhibitory activities against females of the Caribbean fruit fly, Anastrepha suspensa (Loew) (Diptera: Tephritidae). These efforts led discovery three 4a, 4c, 4d with potent insecticidal activity (LD50 range from 0.70 1.91 μg/fly). Among these compounds, 4a exhibited highest potency μg/fly. addition, in silico models indicated that compound is...