A5063415837- Synthesis and biological activity
- Enzyme function and inhibition
- Synthesis and Characterization of Heterocyclic Compounds
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and Catalytic Reactions
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Chemical Reactions and Mechanisms
- Metal complexes synthesis and properties
- Synthesis of Tetrazole Derivatives
- Bioactive Compounds and Antitumor Agents
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Diverse Scientific Research Studies
- Crystallization and Solubility Studies
- Cancer-related molecular mechanisms research
- Photodynamic Therapy Research Studies
- Estrogen and related hormone effects
- Natural Antidiabetic Agents Studies
- X-ray Diffraction in Crystallography
- Nanoparticles: synthesis and applications
- Porphyrin and Phthalocyanine Chemistry
- Cholinesterase and Neurodegenerative Diseases
- Nanoplatforms for cancer theranostics
- Medicinal Plants and Neuroprotection
Sivas Cumhuriyet Üniversitesi
2016-2025
Eskişehir City Hospital
2024
Pamukkale University
2015-2019
Invasive fungal infections (IFIs) are increasing as major infectious diseases around the world, and limited efficacy of existing medications has resulted in substantial morbidity death patients due to lack effective antifungal agents serious drug resistance. In this study, a series benzimidazole-1,2,4-triazole derivatives (6a-6l) were synthesized characterized by 1H NMR, 13C HR-MS spectral analysis. All target compounds screened for their vitro activity against four strains, namely, C....
Abstract This study involved the synthesis and investigation of anticancer antioxidant capabilities six newly developed ligands generated from 1,3,4‐thiadiazole diphenyl ether keto oxime which has never been synthesized before, together with their transition metal complexes. The obtained were characterized using elemental analysis, FTIR, 1 H NMR, 13 C mass spectroscopy. Polymeric complexes by reacting all MCl 2 .nH O (M: Mn 2+ /Co )/Ni /Cu )) salts. polymeric complexes′ structures determined...
Benzimidazole-1,3,4-oxadiazole derivatives (5a-z) were synthesized and characterized with different spectroscopic techniques such as 1 H NMR, 13 C HRMS. The analogs examined against α-glucosidase α-amylase enzymes to determine their antidiabetic potential. Compounds 5g 5q showed the most activity 35.04 ± 1.28 47.60 2.16 µg/mL when compared reference drug acarbose (IC50 = 54.63 1.95 µg/mL). 5g, 5o, 5s, 5x screened enzyme found show excellent potential, IC50 values ranging from 22.39 1.40...
In this study, a series of new benzimidazole-thiadiazole hybrids were synthesized, and the synthesized compounds screened for their antimicrobial activities against eight species pathogenic bacteria three fungal species. Azithromycin, voriconazole, fluconazole used as reference drugs in mtt assay. Among them, 5f 5h showed potent antifungal activity C. albicans with MIC 3.90 μg/mL. Further, results assay 5a, 5b, 5f, proved to be E. faecalis (ATCC 2942) on basis an acceptable value The...
Abstract Hybrid structures containing multiple pharmacophore units with known activity have attracted attention due to their promising outcomes. In this study, several new hybrid benzimidazole and thiadiazole were synthesized. The newly synthesized compounds structurally analyzed using 1H-NMR, 13C-NMR, HRMS, elemental analysis. antimicrobial, in vitro anti-cancer, antioxidant activities of all investigated. antimicrobial the determined against Gram-positive (S. aureus ATCC 29213, E. faecalis...
The aim of this research is the synthesis benzimidazole-1,3,4-oxadiazole derivatives that could be potential anticancer leads inhibiting VEGFR2. compounds were evaluated for their cytotoxicity against cancer cell lines PANC-1, MCF-7, and A549 using MTT assay. Two different normal (hTERT-HPNE CCD-19Lu) used to calculate selectivity indices compounds. Compound 4r showed highest activities, with IC50 = 5.5, 0.3, 0.5 μM A549, MCF-7 lines, respectively. Also, 4s further inhibitory activity VGFRA...
Abstract A new series of hydrazone derivatives ( 1a-1l ) were prepared from a condensation reaction between different hydrazide and 3-formylbenzoic acid. Through the use several spectral techniques, such as 1 H-NMR, 13 C-NMR, elemental analysis, structures compounds clarified. The crystal structure compound 1d was obtained by single-crystal X-ray crystallography. They found to have inhibitory effects on anticancer potentials human carbonic anhydrase isoforms I II. Compound be strongest...
Abstract In this study, we propose identifying potential novel compounds targeting carbonic anhydrase (CA) IX and anticancer activity. To study the impact of these synthesized on CA activity, have developed benzimidazole‐hydrazone derivatives ( 3a–3j ). The target compounds' 1 H NMR (nuclear magnetic resonance), 13 C NMR, high resolution mass spectrometry spectra were used to confirm their chemical structures. L929 (healthy mouse fibroblast cell line) as control healthy line MCF‐7 (breast...
Imidazole derivatives display extensive applications in pharmaceutical chemistry and have been investigated as bioactive compounds for medicinal chemistry. In this study, besides the starting materials (
Abstract We report herein, the design and synthesis of benzimidazole‐oxadiazole derivatives as new inhibitors for vascular endothelial growth factor receptor‐2 (VEGFR‐2). The designed members were assessed their in vitro anticancer activity against three cancer cell lines two normal lines; A549, MCF‐7, PANC‐1, hTERT‐HPNE CCD‐19Lu. Compounds 4c 4d found to be most effective compounds lines. then tested VEGFR‐2 inhibitory activity, safety profiles, selectivity indices using CCD‐19Lu It was...
Thiadiazole and hydrazone derivatives (5a-5i) were synthesized their chemical structures verified described by 1H NMR, 13C HRMS spectra. Three cancer cell lines (MCF-7, MDA, HT-29) one healthy line (L929) used to test the cytotoxicity activity of compounds as well inhibitory against carbonic anhydrase I, II IX isoenzymes. Compound 5d (29.74 µM) had a high effect on hCA I compound 5b (23.18 II. Furthermore, 5i was found be most potent CA IX. Compounds 5a-5i, showed highest anticancer MCF-7...
In this study, some new compounds, which are 2-aminothiadiazole derivatives linked by a phenyl bridge to the 2-position of benzimidazole ring, were designed and synthesized as antimicrobial agents. The structures compounds elucidated 1H 13C NMR spectroscopy, high-resolution mass spectrometry, elemental analysis. antifungal activities tested on Candida albicans, krusei, glabrata, parapsilosis. Compound 5f is more active against C. albicans glabrata than standard fluconazole varicanazole....
Inhibition ofaldose reductase (AR), α-glycosidase (α-GLY), and α-amylase (α-AMY) are some of the essential targets in diabetes mellitus (DM). Here, a series imidazo[1,2-
Abstract The nine new imidazole‐hydrazone derivatives of Schiff base were synthesized from the condensation reactions 1‐methyl‐1 H ‐imidazole‐2‐carbaldehyde with various substituted‐hydrazide derivatives. Structures final compounds ( 1 a – i ) characterized by using NMR, 13 C NMR spectroscopic techniques, elemental analysis, and crystal X‐ray diffraction. in vitro carbonic anhydrase I II potentials these evaluated. result suggests that compound , 4‐methoxy substituted analog an IC 50 0.949...
Abstract The accuracy of risk prediction for coronary artery disease can be improved with the use novel molecular or genetic biomarkers. In this study, we investigated difference five selected microRNAs (miR miRNA) in patients (CAD) and controls, assessed by angiography. study population consisted 85 subjects, aged between 18 75 years underwent invasive Subjects more than 30% stenosis at least one artery, a history prior percutaneous intervention by‐pass surgery were allocated to patient...
In this study, non-peripheral metallophthalocyanine derivatives (2–7) were synthesized. The effect of pH change on the electronic and emission spectra was investigated. compounds 2 6 breast cancer cell lines with photodynamic therapy examined.