A5030690433- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystallography and molecular interactions
- Synthesis and Biological Evaluation
- Electrochemical Analysis and Applications
- Crystal structures of chemical compounds
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Advanced biosensing and bioanalysis techniques
- Supramolecular Chemistry and Complexes
- Computational Drug Discovery Methods
- Electrochemical sensors and biosensors
- Synthesis and Reactions of Organic Compounds
- Molecular Sensors and Ion Detection
- Quinazolinone synthesis and applications
- Free Radicals and Antioxidants
- Nonlinear Optical Materials Research
- Molecular Junctions and Nanostructures
- Quantum Dots Synthesis And Properties
- Bioactive Compounds and Antitumor Agents
- DNA and Nucleic Acid Chemistry
- Inorganic and Organometallic Chemistry
- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis of Tetrazole Derivatives
Hitit Üniversitesi
2011-2025
Centre de Recherche en Économie et Management
2021
Gazi University
2021
Hacettepe University
2007-2015
Bilkent University
2015
University of Turin
2010
In this study, we designed, synthesized, and evaluated a series of 1,2,4-triazole benzimidazoles for their cytotoxic effects against the A549, C6, NIH3T3 cell lines. Additionally, these compounds were assessed inhibitory activity DNA topoisomerase I, aiming to develop novel anticancer agents. The synthesized final
In this study, a series of new benzimidazole-thiadiazole hybrids were synthesized, and the synthesized compounds screened for their antimicrobial activities against eight species pathogenic bacteria three fungal species. Azithromycin, voriconazole, fluconazole used as reference drugs in mtt assay. Among them, 5f 5h showed potent antifungal activity C. albicans with MIC 3.90 μg/mL. Further, results assay 5a, 5b, 5f, proved to be E. faecalis (ATCC 2942) on basis an acceptable value The...
The aim of this research is the synthesis benzimidazole-1,3,4-oxadiazole derivatives that could be potential anticancer leads inhibiting VEGFR2. compounds were evaluated for their cytotoxicity against cancer cell lines PANC-1, MCF-7, and A549 using MTT assay. Two different normal (hTERT-HPNE CCD-19Lu) used to calculate selectivity indices compounds. Compound 4r showed highest activities, with IC50 = 5.5, 0.3, 0.5 μM A549, MCF-7 lines, respectively. Also, 4s further inhibitory activity VGFRA...
Abstract Developing precise, quick, and affordable calf thymus double stranded deoxyribonucleic acid, ct‐dsDNA, detection methods understanding the structural alterations of ct‐dsDNA following exposure to antineoplastic drugs is extraordinarily prominent. In this context, destination search thrive an electrochemical biosensor quantify bexarotene (BEX) elucidate its DNA interaction mechanism. The mechanism between BEX was analyzed by differential pulse voltammetry, fluorescence spectroscopy,...
Green nanoparticle production is widespread, dependable, affordable, and ecologically beneficial.
In this study, some new compounds, which are 2-aminothiadiazole derivatives linked by a phenyl bridge to the 2-position of benzimidazole ring, were designed and synthesized as antimicrobial agents. The structures compounds elucidated 1H 13C NMR spectroscopy, high-resolution mass spectrometry, elemental analysis. antifungal activities tested on Candida albicans, krusei, glabrata, parapsilosis. Compound 5f is more active against C. albicans glabrata than standard fluconazole varicanazole....
Some novel substituted thiazolylhydrazine derivatives were designed, synthesized and their inhibitory effects on acetylcholinesterase (AChE) butyrylcholinesterase (BuChE) enzymes antioxidant activities investigated. The structures of the compounds determined using different spectroscopic techniques such as 1H-NMR, 13C-NMR, HRMS. According to enzyme inhibition results, showed selectivity against BuChE inhibition. Compounds 5e, 5g, 5i 5j displayed significant potencies. Among them, compound...
Abstract Epidermal growth factor receptor (EGFR), one of the important targets in development anticancer compound, is a member ErbB tyrosine kinase family and highly expressed solid tumors. Inhibition EGFR for cancer treatment to inhibit progression EGFR‐expressing tumor cells. Agents targeting are successful drugs involved various cancers, particularly colorectal, head, neck, lung, breast cancers. In this study, design some novel benzimidazole compounds that can interact with enzyme,...
Two hetarylazo indole dyes were analyzed by single crystal X‐ray diffraction. Dye 1 , C 18 H 14 N 4 O, crystallises in the monoclinic system, space group P2 /c, with two independent molecules asymmetric unit. 2 20 16 also /n, Z = 4. In both compounds, there are intramolecular C–H...N hydrogen bonds which influenced molecular conformation between azo and ring system its phenyl substituent. Each of dye interact through N–H...N bond, whereas no classical intermolecular bond was observed . The...
Clusters of (ZnO)n (n = 2-4) have been shown to play a central role in the detection glucose entity based on existence photo-induced electrons (PE), which facilitates interaction between clusters and guests. The electrochemistry experiment has confirmed by title clusters. optimization, energetic parameters, vibrational frequency calculations indicated that Cu-Znn-1On-glucose are more stable than (ZnO)n-glucose complexes. It demonstrated Cu doping enhanced chemical behavior formed high...
In this study, to detect thiram electrochemically, a simple nanosensor based on glassy carbon electrode (GCE) modified with green-synthesized Ag and Au nanoparticles was designed. AuNPs@AgNPs/GCE gave considerably greater signal for 5 ppm in pH 3.0 phosphate buffer solution using adsorptive stripping differential pulse voltammetry compared bare GCE. Under ideal conditions, the produced linear concentration calibration curve extending from 0.2 1.4 thiram, limits of detection quantification...
We present ab initio study using dispersion-corrected density functional theory calculations to investigate the hydrogen interaction with Ti-coated, one end closed, single-walled carbon nanotube (SWCNT). Our results demonstrate that a single Ti atom binds up five molecules on SWCNT cap top, whereas adsorption of four is energetically more favourable. The analyses from energy profile, highest occupied molecular orbital–lowest unoccupied orbital gap and Mulliken charge distribution show...