A5038721436- Computational Drug Discovery Methods
- Synthesis and biological activity
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Malaria Research and Control
- Essential Oils and Antimicrobial Activity
- Diverse Scientific Research Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Pharmacological Effects of Natural Compounds
- Ethnobotanical and Medicinal Plants Studies
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmacogenetics and Drug Metabolism
- Medicinal Plant Research
- Synthesis and Biological Evaluation
- Curcumin's Biomedical Applications
- Herbal Medicine Research Studies
- Bioactive Compounds and Antitumor Agents
- Nanoparticle-Based Drug Delivery
- Free Radicals and Antioxidants
- Phytochemicals and Medicinal Plants
- Tea Polyphenols and Effects
- Nanoparticles: synthesis and applications
- Drug-Induced Hepatotoxicity and Protection
- Click Chemistry and Applications
- Phytochemistry and Biological Activities
Vignan's Foundation for Science, Technology & Research
2023-2025
Shri Vile Parle Kelavani Mandal
2021-2023
University of Delhi
2023
Integral University
2023
Manipal Academy of Higher Education
2023
Jamia Hamdard
2023
University of Kufa
2023
Dibrugarh University
2012-2022
Sandip Foundation
2020-2021
Savitribai Phule Pune University
2021
Cyclooxygenase (COX) and Lipoxygenase (LOX) are essential enzymes for arachidonic acid (AA) to eicosanoids conversion. These AA-derived initiating immunological responses, causing inflammation, resolving inflammation. Dual COX/5-LOX inhibitors believed be promising novel anti-inflammatory agents. They inhibit the synthesis of prostaglandins (PGs) leukotrienes (LTs), but have no effect on lipoxin formation. This mechanism combined inhibition circumvents certain limitations selective COX-2...
Polyphenols, as secondary metabolites ubiquitous in plant sources, have emerged pivotal bioactive compounds with far-reaching implications for human health. Plant polyphenols exhibit direct or indirect associations biomolecules capable of modulating diverse physiological pathways. Due to their inherent abundance and structural diversity, garnered substantial attention from both the scientific clinical communities. The review begins by providing an in-depth analysis chemical intricacies...
Due to the unavailability specific drugs or vaccines (FDA approved) that can cure COVID-19, development of potent antiviral drug candidates/therapeutic molecules against COVID-19 is urgently required. This study was aimed at in silico screening and polyphenolic phytochemical compounds a rational way by virtual screening, molecular docking dynamics studies SARS-CoV-2 main protease (Mpro) papain-like (PLpro) enzymes. The objective identify plant-derived and/or flavonoid as possible agents with...
Flavonoids comprise a large group of structurally diverse polyphenolic compounds plant origin and are abundantly found in human diet such as fruits, vegetables, grains, tea, dairy products, red wine so on. Major classes flavonoids include flavonols, flavones, flavanones, flavanols, anthocyanidins, isoflavones, chalcones. Owing to their potential health benefits medicinal significance, now considered an indispensable component variety medicinal, pharmaceutical, nutraceutical, cosmetic...
In view of the potential traditional plant-based remedies (or phytomedicines) in management COVID-19, present investigation was aimed at finding novel anti-SARS-CoV-2 molecules by
Severe acute respiratory syndrome coronavirus disease (SARS-CoV-2) induced 2019 (COVID-19) pandemic is the present worldwide health emergency. The global scientific community faces a significant challenge in developing targeted therapies to combat SARS-CoV-2 infection. Computational approaches have been critical for identifying potential inhibitors face of limited resources and this time crisis. Main protease (Mpro) an intriguing drug target because it processes polyproteins required...
Abstract The Kirsten rat sarcoma (KRAS) oncoprotein has been on drug hunters list for decades now. Initially considered undruggable, recent advances have successfully broken the jinx through covalent inhibition that exploits mutated cys12 in switch II binding pocket (KRAS G12C ). Though this approach achieved some level of success, patients with mutations other than are still uncatered for. KRAS G12D is most frequent oncoprotein. It only until recently, MRTX1133 discovered as a potential...
The inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) and papain-like (PLpro) prevents viral multiplications; these enzymes have been recognized as one the most favorable targets for drug discovery against SARS-CoV-2. In present study, we screened 225 phytocompounds in 28 different Indian spices to identify compounds potential inhibitors SARS-CoV-2 Mpro PLpro. Molecular docking, molecular dynamics simulation, mechanics Poisson-Boltzmann surface...
Abstract A new series of novel dipeptide sulfonamide analogues were designed, synthesized, and screened for their in silico studies vivo antimalarial activities. The synthesized compounds (50 mg/Kg) showed significant activity against P. berghei (NK65) with % inhibition values (5.9 to 64.7 %) range when compared reference drug, artemisinin (66.7 a four day suppressive assay. predicted favorable binding affinity target protein residues high dock score falciparum falcipain 2 (FP‐2) 3 (FP‐3)...
Abstract For decades the direct targeting of KRAS as a driver non‐small cell lung cancer, colorectal and pancreatic cancers well inhibition RAF‐MEK‐ERK pathway has shown little success due to feedback networks that keep in control. Inhibiting SOS1, activator, therefore become promising escape route treating KRAS‐driven cancers. The search for SOS1 inhibitors since gained momentum although no drug been approved yet. Owing time‐consuming difficult processes characterize discovery approval...
To valorise the bioactive constituents abundant in leaves and other parts of medicinal plants with objective to minimize plant-based wastes, this study was undertaken. The main constituent Andrographis paniculata, an Asian plant, is andrographolide (AG, a diterpenoid), which has shown promising results treatment neurodegenerative illnesses. Continuous electrical activity brain hallmark abnormal neurological conditions such as epilepsy (EY). This can lead sequelae. In study, we used GSE28674...
In this article, a comprehensive review on bioactive flavonoids that are abundant in medicinal and functional food (dietary) plants has been made, with special reference to antimalarial flavonoid molecules. Flavonoids have found exist plants/plant medicines comprising numerous poly-phenolic compounds wide structural diversity having pharmacologi-cal potential diverse range of therapeutic areas. derived from certain dietary described herein investigated for their an-timalarial effectiveness...
In the present study, biopotential of capsaicin (an active principle capsicum) as a topical antiarthritic agent was studied in arthritic rats. Transfersomal vesicular system employed for administration experimental The characterization prepared capsaicin-loaded transfersomes reveals their nano size (94 nm) with negative surface charge (-14.5 mV) and sufficient structural flexibility, which resulted 60.34% entrapment efficacy, penetration across biomembrane (220 µm) 76.76% drug release from...
The current outbreak of novel Coronavirus Disease-2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major pandemic situation and catastrophe for humans. COVID-19 infectious disease particularly the system characterized fatal complications such as distress (SARS), pneumonia, cardiac arrhythmia, kidney failure/ multiple organ failure even death. Since its discovery, SARS-CoV-2 has spread across 213 countries or territories, causing more than 8.5...