A5008929870- Synthesis and biological activity
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Natural Antidiabetic Agents Studies
- Enzyme function and inhibition
- Oxidative Organic Chemistry Reactions
- Multicomponent Synthesis of Heterocycles
- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Synthesis of Organic Compounds
- Nanoparticles: synthesis and applications
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Reactions
- Biochemical and Molecular Research
- Ferrocene Chemistry and Applications
- Click Chemistry and Applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- Nanomaterials for catalytic reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Corrosion Behavior and Inhibition
- Cancer therapeutics and mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Synthesis of Indole Derivatives
- PI3K/AKT/mTOR signaling in cancer
- Sulfur-Based Synthesis Techniques
University of Tabuk
2016-2025
The 7-quinolinyl-bearing triazole analogs were synthesized (1d-19d) and further assessed in vitro for their inhibitory profile against α-amylase andα-glucosidase. entire showed a diverse range of activities having IC50 values between 0.80 ± 0.05 µM to 40.20 0.70 (α-amylase) 1.20 0.10 43.30 (α-glucosidase) under the positive control acarbose (IC50 = 10.30 0.20 µM) 9.80 as standard drug. Among scaffolds, seven scaffolds 12d, 10d, 8d, 9d, 11d, 5d, 14d excellent α-glucosidase potentials with...
Abstract For decades the direct targeting of KRAS as a driver non‐small cell lung cancer, colorectal and pancreatic cancers well inhibition RAF‐MEK‐ERK pathway has shown little success due to feedback networks that keep in control. Inhibiting SOS1, activator, therefore become promising escape route treating KRAS‐driven cancers. The search for SOS1 inhibitors since gained momentum although no drug been approved yet. Owing time‐consuming difficult processes characterize discovery approval...
Different research synthetic methods have been developed recently for the synthesis of bis-benzimidazole analogs to investigate various biological significances. In this present study, an attempt was made synthesize a new series in fast and efficient method. A variety spectroscopic techniques, including 13C NMR, 1H HREI-MS, were used establish existence every synthesized scaffold. Molecular docking profiles also carried out ascertain binding interactions compounds. All derivatives (1–18)...
The current study was conducted to obtain hybrid analogues of indole-based thiadiazole derivatives (1-16) in which a number reaction steps were involved. To examine their biological activity the presence reference drug Donepezil (0.21 ± 0.12 and 0.30 0.32 M, respectively), inhibitory potentials AChE BuChE determined for these compounds. Different substituted showing varied range profiles, when compared drug, analogue 8 shown have potent activity, with IC50 values AchE 0.15 0.050 M 0.20 0.10,...
In this study, hybrid analogs of benzimidazole containing a thiazole moiety (1-17) were afforded and then tested for their ability to inhibit α-amylase α-glucosidase when compared acarbose as standard drug. The recently available showed wide variety inhibitory potentials that ranged between 1.31 ± 0.05 38.60 0.70 µM (against α-amylase) 2.71 0.10 42.31 α-glucosidase) under the positive control (IC50 = 10.30 0.20 against 9.80 α-glucosidase). A structure-activity relationship (SAR) study was...
The clinical significance of benzimidazole-containing drugs has increased in the current study, making them more effective scaffolds. These moieties have attracted strong research interest due to their diverse biological features. To examine various significances, several synthetic methodologies recently been established for synthesis benzimidazole analogs. present study aimed efficiently and quickly synthesize a new series Numerous spectroscopic techniques, including 1H-NMR, 13C-NMR,...
A unique series of sulphonamide derivatives was attempted to be synthesized in this study using a new and effective method. All the compounds were verified several spectroscopic methods, including FTIR, 1H-NMR, 13C-NMR, HREI-MS, their binding interactions studied molecular docking. The enzymes urease α-glucosidase evaluated against each derivative (1-15). When compared respective standard drug such as acarbose thiourea, almost all shown have excellent activity. Among screened series, analogs...
Abstract A facile, mild, effective, and multicomponent protocol for the production of 4‑phosphorylated‐4H‑chromenes through an aldol condensation, Michael addition, cyclization was established. The C─C, C─P, C─O bonds were constructed during reaction to produce desired product from 2‐hydroxybenzyl alcohols. synthesized compounds characterized by standard techniques. important features this are operational simplicity, moderate conditions, use a low‐cost iron complex, high atom economy.
Twenty-four analogs based on triazinoindole bearing benzimidazole/benzoxazole moieties (
Abstract Mycobacterium tuberculosis β‐ketoacyl‐ACP synthase I (KasA) involves in mycolic acid biosynthesis for cell wall maintenance; hence, it is a critical target TB drug design. Thiolactomycin (TLM) and derivatives are the known standard KasA enzyme activity inhibitors. However, TLM analogues have poor against protein. Indazole sulphonamide chemotype (JSF‐3285/JFX) was recently reported as promising inhibitor. JSF‐3285 mechanism unclear; thus, provides means designing This study unfolds...
The thermochemical conversion of biomass into biochar (BC) provides a valuable platform towards green and sustainable synthesis functional carbon nanomaterials for advanced technological applications. Herein, we report biosynthesis Oryza sativa (rice husk) nanocomposites incorporated with bimetallic Cu MnO (Cu/MnO) nanoparticles as multifunctional materials (Cu/MnO@BC) high-performance anode in Li-ion batteries (LIBs) oxidative removal organic dyes from aqueous solutions. 3D network...
Abstract The present article considers a comparative analysis of two elastomers, polyurethane (PUС) and organosilicon (OSC), both modified with 1.0–9.0 wt.% multiwall carbon nanotubes (MWCNTs). MWCNTs‐1 MWCNTs‐2 were synthesized through CVD method using Co‐Mo/Al 2 O 3 ‐MgO Fe‐Co/ 2,1 Al . results obtained showed that the lowest bulk conductivity (5 × 10 −10 S cm −1 ) was typical for PUC elastomer 1 MWCNTs‐2. As OSC (modified 9 MWCNTs‐1), found to be 0.4 maximum temperature field uniformity...
A series of novel phenothiazine-containing imidazo[1,2-
Abstract A facile synthetic method of flavone and coumarin based isoxazoles, tri‐substituted isoxazoles is reported using aromatic aldehydes, hydroxylamine hydrochloride O ‐propargyl flavones/coumarin, internal acetylene via one‐pot condensation subsequent [3+2] cycloaddition in the presence phenyliodinediacetate (PIDA) under mild reaction conditions. This methodology also successfully applied for containing heterocyclic ring such as furan thiophene. One‐pot, high yields (90‐75%), shorter...
The interaction of the cationic surfactant cetyltrimethylammonium bromide (CTAB) with amino acids (Lysine and Serine) in water binary solvent combinations (Water-Ethyl Acetate) was studied conductometrically this work. Solution formation method used to study effect different parameters on interactions. Measured specific data were calculate temperature concentration added micellization surfactant. Thermodynamic for i.e., Gibb's energy (ΔGm), enthalpy (ΔHm), entropy (ΔSm) have also been...
Abstract A simple, and environmentally benign synthesis of 2,4,5‐trisubstituted 1,2,4,5‐tetrasubstituted imidazoles has been successfully accomplished via multi‐component cyclo‐condensation 1,2‐dicarbonyl, aldehyde, ammonium acetate aniline respectively, using dihydroquinoline based novel organocatalysts at refluxed temperature in ethanol. High yields (94 %), easy work‐up purification products without column chromatography are the key advantages method.
Some novel pyrazoline‐based organometallic compounds were synthesized as new leads in antimicrobial chemotherapy. The structures of elucidated by different spectroscopic techniques and elemental analyses. All investigated for vitro studies against fifteen ATTC bacterial fungal strains. microbial susceptibility these revealed that all the tested gave good minimum inhibitory concentration (MIC) values organisms are either similar or even better than reference drugs amoxicillin fluconazole,...