A5036112825- Synthesis and biological activity
- Catalytic Cross-Coupling Reactions
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Synthesis of Organic Compounds
- Metal complexes synthesis and properties
- Microbial Applications in Construction Materials
- Marine Sponges and Natural Products
- Fluorine in Organic Chemistry
- Synthesis and Characterization of Heterocyclic Compounds
- Asymmetric Synthesis and Catalysis
- Synthesis and Biological Activity
- Catalytic C–H Functionalization Methods
- Natural Antidiabetic Agents Studies
- Organometallic Compounds Synthesis and Characterization
- Organic Chemistry Synthesis Methods
- Synthesis and Reactions of Organic Compounds
- Crystallization and Solubility Studies
- Enzyme function and inhibition
- Carbohydrate Chemistry and Synthesis
- X-ray Diffraction in Crystallography
- Crystal structures of chemical compounds
- Multicomponent Synthesis of Heterocycles
- Organometallic Complex Synthesis and Catalysis
- Click Chemistry and Applications
Hazara University
2013-2024
University of Rostock
2009-2014
Quaid-i-Azam University
2008-2012
Albert Einstein College of Medicine
2010
Chitosan, polyvinyl alcohol (PVA), and pyrrolidone (PVP) were used to formulate a controlled transdermal drug delivery system for tramadol.
Ureases are important in both agriculture and human health. Bacterial ureases directly involved many farm-field problems pathological conditions. Here, we report a structure-based virtual screening of an in-house compound bank about 6000 molecular entities by computational docking binding free energy calculations followed vitro screening. Applied protocol leads to the identification novel urease inhibitors, which can serve as starting points for structural optimization.
Twenty-four analogs based on triazinoindole bearing benzimidazole/benzoxazole moieties (
α-Glucosidase and urease inhibitors have emerged as crucial for developing therapeutic drugs targeting diabetes gastrointestinal disorders. This study reports on new series of ibuprofen mefenamic acid Schiff base derivatives incorporating isatin dual α-glucosidase enzymes. These synthesized (7a-r) were structurally characterized by 1H NMR, 13C NMR HRMS (EI). Biological evaluation (IC50) identified several i.e., 7a (urease = 17.37 ± 1.37 µM, 44.1 1.15 µM), 7j, 16.61 81.2 1.33 7o, 18.63 1.27...
A series of 28 novel naproxen derivatives (4a-f, 5a-f, 6a-d, 7a-f, and 8a-f) have been designed, synthesized, characterized. The synthesized were assessed as dual inhibitors for 15-lipoxygenase (LOX) α-glucosidase enzymes checked cytotoxicity ADME studies. inhibitory potential 15- LOX was through two different methods, the UV absorbance method Chemiluminescence method. biological activities result revealed that method, compound 4f (IC50 21.31 ± 0.32 µM) found potent among followed by...
The Me(3)SiOTf-mediated condensation of 1-ethoxy-2-fluoro-1,3-bis(trimethylsilyloxy) 1,3-dienes with 3-cyanochromones afforded 3-cyano-2-(4-ethoxy-3-fluoro-2,4-dioxobutyl)chroman-4-ones. Their reaction triethylamine fluorinated azaxanthones or biaryls. product distribution depends on the structure diene. formation biaryls can be explained by an unprecedented domino "retro-Michael/aldol/fragmentation" reaction.
Abstract 2‐Aryl‐2,3‐dihydro‐4 H ‐pyran‐4‐ones were prepared in one step by cyclocondensation of 1,3‐diketone dianions with aldehydes. The use HCl (10%) for the aqueous workup proved to be very important avoid elimination reactions 5‐aryl‐5‐hydroxy 1,3‐diones formed as intermediates. TiCl 4 ‐mediated cyclization a 2‐aryl‐2,3‐dihydro‐4 ‐pyran‐4‐one 1,3‐silyloxybuta‐1,3‐diene resulted cleavage pyranone moiety and formation highly functionalized benzene derivative.
Aryl-substituted pyridines and pyrimidines were prepared by [4+2] cycloadditions of alkynyl-substituted -pyrimidines with electron-rich dienes. The reactions proceed formation a bridged cycloadduct subsequent thermal extrusion ethylene. pyridine moiety plays crucial role for the success reaction.
This study reports the synthesis of a series ibuprofen derivatives, including thiosemicarbazides 4a-f, 1,3,4-oxadiazoles 5a-f, 1,3,4-thiadiazoles 6a-f, 1,2,4-triazoles 7a-f, and their S-alkylated derivatives 8a-d. All newly synthesized were analyzed using 1 H NMR, 13 C NMR spectroscopy, high-resolution mass spectra (electron ionization) spectrometry. These synthetic molecules examined for in vitro baking yeast α-glucosidase soybean 15-lipoxygenase (15-LOX) inhibition cell viability studies....
In this study, ternary blends based on chitosan, polyvinyl alcohol, and polyethylene glycol reinforced with organically modified montmorillonite (nanoclay) clay were synthesized. These evaluated as transdermal drug delivery patches using tramadol a model drug. The FTIR study showed interaction among important functional groups compatibility the mixing components. Among drug-loaded formulations, composite MA12 shows maximum thermal stability 27.9% weight residue at 540°C. prepared...
This study aim to synthesize new 1,3,4-oxadiazole derivatives incorporating mefenamic acid as promising α-glucosidase and urease inhibitors, potentially leading the treatment of postprandial hyperglycemia well H. pylori related disorders. In this regards, we have designed a series Mefenamic derivatives. The synthetic compounds were structurally elucidated through 1H NMR, 13C NMR HR-EIMS analysis. biological evaluation these against enzyme depicted some novel with potent inhibition said...
Cancer is one of the most fatal diseases globally, however, advancement in field nanoscience specifically novel nanomaterials with nano-targeting cancer cell lines has revolutionized diagnosis and therapy thus attracted attention researchers related fields. Carbon Dots (CDs)–C-based nanomaterials–have emerged as highly favorable candidates for simultaneous bioimaging during nano-theranostics due to their exclusive innate FL theranostic characteristics exhibited different preclinical results....
The Suzuki-Miyaura reaction of N-methyl-2,3-dibromoindole with two equivalents boronic acids gave symmetrical 2,3-diarylindoles. one equivalent arylboronic acid resulted in site-selective formation 2-aryl-3-bromoindoles. one-pot 2,3-dibromoindole different afforded unsymmetrical 2,3-diarylindoles containing aryl groups.