A5074589101- Synthesis and biological activity
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Quinazolinone synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Natural Antidiabetic Agents Studies
- Bioactive Compounds and Antitumor Agents
- Cholinesterase and Neurodegenerative Diseases
- Enzyme function and inhibition
- Click Chemistry and Applications
- Cancer Mechanisms and Therapy
- Phenothiazines and Benzothiazines Synthesis and Activities
- Multicomponent Synthesis of Heterocycles
- Analytical Chemistry and Chromatography
- Synthesis and Catalytic Reactions
- Hepatitis C virus research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Protein Interaction Studies and Fluorescence Analysis
- Synthesis and Reactions of Organic Compounds
- Biochemical and Molecular Research
- Advanced Breast Cancer Therapies
- Metal complexes synthesis and properties
- Monoclonal and Polyclonal Antibodies Research
King Saud University
2013-2025
University of Tabuk
2025
King Fahd Military Medical Complex
2022-2024
Ministry of Health
2023-2024
National Guard Health Affairs
2024
King Saud bin Abdulaziz University for Health Sciences
2022-2023
Northern Border University
2023
King Faisal Specialist Hospital & Research Centre
2023
Riyadh Elm University
2019
University of Liverpool
2010
The current study has afforded twelve analogs (4a-l) of pyridine-derived bis-oxadiazole containing bis-schiff base and subsequently evaluated for their potential to inhibit thymidine phosphorylase(in vitro). All the synthesized were structurally elucidated using various spectroscopic tools including NMR HREIMS. scaffolds showed varied range inhibitory with IC50values ranging from 5.19 ± 1.10 36.18 4.60 μM in comparison 7-deazaxanthine (IC50 = 30.28 2.10 μM) as a standard drug. (except analog...
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a critical role in cancer angiogenesis. Inhibition of VEGFR-2 activity proved effective suppression tumour propagation. Accordingly, two series new 3-methylquinoxaline derivatives have been designed and synthesised as inhibitors. The were evaluated vitro for their cytotoxic activities against MCF-7and HepG2 cell lines. In addition, the inhibitory target compounds estimated to indicate potential mechanism cytotoxicity. To great...
A new series of 3-methylquinoxaline-based derivatives having the same essential pharmacophoric features as VEGFR-2 inhibitors have been synthesized and evaluated for their antiproliferative activities against two human cancer cell lines, MCF-7 HepG-2. Compounds 15b 17b demonstrated a significant effect with IC50 ranging from 2.3 to 5.8 μM. An enzymatic assay was carried out all tested candidates VEGFR-2. Compound most potent inhibitor (IC50 = 2.7 nM). Mechanistic investigation including...
The interaction between erlotinib (ERL) and bovine serum albumin (BSA) was studied in the presence of quercetin (QUR), a flavonoid with antioxidant properties. Ligands bind to transport protein BSA resulting competition different ligands displacing bound ligand, higher plasma concentrations. Therefore, various spectroscopic experiments were conducted addition silico studies evaluate behavior BSA-ERL system absence QUR. quenching curve binding constants values suggest QUR ERL BSA. constant...
Plants of the genus Centaurea have been widely used as natural therapeutics in different countries. This study investigated antioxidant-structure activity relationship eight flavonoids isolated from scoparia using DFT studies and vitro radical scavenging xanthine oxidase (XO) inhibition assays, to correlate theoretical values with experimental findings. Docking analysis was carried out explore binding modes phytochemicals XO bovine β-lactoglobulin (BLG). Interactions compounds BLG were...
The present work described the synthetic procedure adopted for synthesis of bis-indole-based triazine derivatives via a series reactions. All compounds were synthesized through stepwise reaction. After being confirmation thin-layer chromatography (TLC) these characterized various spectroscopic techniques including 1HNMR, 13CNMR and HREI-MS evaluated against beta-glucuronidase in presence standard drug D-saccharic acid 1,4 lactone (IC50 = 31.2 ± 1.0 µM). Most found with better to good...
Alzheimer's disease (AD) is a progressive neurological illness that distinguished clinically by cognitive and memory decline adversely affects the people of old age. The treatments for this gained much attention have prompted increased interest among researchers in field. As springboard to explore new anti-Alzheimer's chemical prototypes, present study was carried out synthesis benzoxazole-oxadiazole analogues as effective inhibitors. In research work, we focused our efforts synthesize...
Aim: Recently, thiadiazole-containing drugs have gained greater clinical relevance and are being explored for the development of new antidiabetic, antiurease antimicrobial agents that target drug resistance. Methods & results: The authors disclose synthesis N-(5-[4-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl)methanimine derivatives starting from 4-(trifluoromethyl)benzoic acid. All synthesized were evaluated their biological potential in order to investigate inhibitory activity against...
Carbohydrate analogs are an important, well-established class of clinically useful medicinal agents that exhibit potent antimicrobial activity. Thus, we explored the various therapeutic potential methyl α-D-mannopyranoside (MαDM) analogs, including their ability to synthesize and assess antibacterial, antifungal, anticancer properties; additionally, molecular docking, dynamics simulation, ADMET analysis were performed. The structure synthesized MαDM was ascertained by spectroscopic...
Herein, a new wave of bis([1, 2, 4]triazolo)[4,3-a:3',4'-c]quinoxaline derivatives have been successfully designed and synthesised. The synthesised were biologically investigated for their cytotoxic activities against HepG2 MCF-7. Also, the tested compounds further examined in vitro VEGFR-2 inhibitory activity. most promising derivative 23j was its apoptotic behaviour cell lines using flow cytometric western-plot analyses. Additional in-silico studies performed to predict how can bind...
There is an urgent need to design new anticancer agents that can prevent cancer cell proliferation even with minimal side effects. Accordingly, two series of 3-methylquinoxalin-2(1H)-one and 3-methylquinoxaline-2-thiol derivatives were designed act as VEGFR-2 inhibitors. The synthesised evaluated in vitro cytotoxic against human lines namely, HepG-2 MCF-7. Also, the assessed for their VEGFR-2inhibitory effect. most promising member 11e further investigated reach a valuable insight about its...
The synthesis of 5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b]quinazolin-9(4H)-one (THTQ), a potentially biologically active compound, was pursued, and its structure determined through sequence spectral analysis, including 1H-NMR, 13C-NMR, IR, HRMS. Four bacterial four fungal strains were evaluated for their susceptibility to the antibacterial antifungal properties THTQ compound using well diffusion method. impact on corrosion mild steel in 1 M HCl solution various methods such as weight loss,...
There is an increasing prevalence of diabetes mellitus throughout the world, and new compounds are necessary to combat this. The currently available antidiabetic therapies long-term complicated side effect-prone, this has led a demand for more affordable effective methods tackling diabetes. Research focused on finding alternative medicinal remedies with significant efficacy as well low adverse effects. In research work, we have our efforts synthesize series 1,2,4-triazole-based...
To discover anti-acetylcholinesterase agents for the treatment of Alzheimer's disease (AD), a series novel Schiff base-coumarin hybrids was rationally designed, synthesized successfully, and structurally characterized using Fourier transform infrared (FTIR), Nuclear magnetic resonance (NMR), High-Resolution Mass Spectrometry (HRMS) analyses. These were evaluated their potential inhibitory effect on acetylcholinesterase (AChE). All them exhibited excellent activity against AChE. The IC50...
The aim of this study is to purify industrial textile effluents by treating two types commonly encountered dyes: blue maxilon (BM), cationic nature, and black eriochrome (NE), anionic nature. We intend employ an innovative approach based on the adsorption these dyes onto a novel vegetal biomaterial derived from Aleppo pine fibers (FPAs). A kinetic thermodynamic was conducted. effect some physicochemical parameters both dye FPAs also evaluated. modeling results performed using Langmuir,...
A synthesized and promising biologically hypoglycemic compound 5,6-Dichloro-2-[2-(pyridin-2-yl)ethyl]isoindoline-1,3-dione ( 5e ) was studied for its binding to a model protein (bovine serum albumin; BSA) by spectroscopic molecular simulation approaches. Fluorescence studies revealed that quenched BSA's intrinsic fluorescence static quenching. The experiments were performed at three different temperatures the quenching constants evaluated. Stern-Volmer constant (K sv values decreased from...