A5069114214- Analytical Methods in Pharmaceuticals
- Advanced Breast Cancer Therapies
- Pancreatic function and diabetes
- Analytical Chemistry and Chromatography
- Chronic Myeloid Leukemia Treatments
- Organic Electronics and Photovoltaics
- Spectroscopy and Chemometric Analyses
- PI3K/AKT/mTOR signaling in cancer
- Pesticide Residue Analysis and Safety
- Computational Drug Discovery Methods
- Synthesis and biological activity
- Metabolism, Diabetes, and Cancer
- Cancer therapeutics and mechanisms
- Conducting polymers and applications
- Quinazolinone synthesis and applications
- Chronic Lymphocytic Leukemia Research
- Antibiotics Pharmacokinetics and Efficacy
- Lung Cancer Treatments and Mutations
- Cholinesterase and Neurodegenerative Diseases
- Pharmacogenetics and Drug Metabolism
- Analytical Chemistry and Sensors
- HER2/EGFR in Cancer Research
- Perovskite Materials and Applications
- Synthesis and Biological Evaluation
- Neuroscience and Neuropharmacology Research
King Saud University
2016-2025
Cairo University
2014-2023
Riyadh Elm University
2016-2020
Field Crops Research Institute
2016
Universiti Sains Malaysia
2014
The process of developing new drugs is greatly hampered by their inadequate physicochemical, pharmacokinetic, and intrinsic characteristics. In this regard, the selected chloro indolinone, (Z)-6-chloro-3-(2-chlorobenzylidene)indolin-2-one (C1), nitro (Z)-6-chloro-3-(2-nitrobenzylidene)indolin-2-one (C2), were subjected to SwissADME density function theory (DFT) analysis. For compounds C1 C2, BOILED-Egg pharmacokinetic model predicted intestinal absorption, blood–brain barrier (BBB)...
ABSTRACT Polymeric hole transport materials (HTMs) have emerged because of their potential to produce dopant‐free, efficient, and stable perovskite solar cells (PSCs). Therefore, we engineered 10 novel donor (SMH1–SMH10) containing phenanthrocarbazole‐based polymeric structures for organic PSCs. These molecules underwent bridging‐core modifications using different spacers, such as furan (N1), pyrrole (N2), benzene (N3), pyrazine (N4), dioxane (N5), isoxazole (N6), isoindole (N7), indolizine...
Cadmium is an environmental contaminant associated with marked neurotoxicity and cognitive impairment. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, has demonstrated promising neuroprotection against cerebral ischemia diabetic dementia. However, there been no study of its effect on cadmium-induced deficits. In the present work, linagliptin’s prospective neuroprotective effects cadmium-evoked decline were examined in vivo rats. The molecular pathways related to oxidative stress,...
In the present work, a concise library of benzothiazole-derived pyrazoline-based thiazole (1-17) was designed and synthesized by employing multistep reaction strategy. The newly compounds were screened for their α-glucosidase urease inhibitory activities. scaffolds characterized using combination several spectroscopic techniques, including FT-IR, 1H-NMR, 13C-NMR, EI-MS. majority demonstrated notable potency against enzymes. These analogues disclosed varying degrees activities, with IC50...
Alzheimer’s disease (AD) is the most common form of neurodegenerative disorders worldwide. Its pathologic features include massive neuroinflammation with abnormal deposition β-amyloid peptide in cerebral tissues leading to degeneration brain neurons. Adverse effects associated traditional drugs used for treatment this pathological condition have directed research efforts towards searching alternative effective agents minimal adverse effects. The aim study was elucidate potential ameliorative...
Cognitive decline and Alzheimer-like neuropathology are common manifestations of cadmium toxicity. Thanks to its antioxidant/anti-apoptotic features, dapagliflozin has demonstrated promising neuroprotective actions. However, effect on cadmium-induced neurotoxicity is lacking. The present work aimed examine whether could protect rats from cadmium-evoked cognitive decline. In this study, the behavioral disturbances hippocampal biomolecular alterations were studied after receiving...
Vandetanib (Caprelsa tablets, VNT) is an orally inhibitor of vascular endothelial growth factor receptor 2. The current research reports the characterization and identification in vitro, vivo reactive intermediates VNT. In vitro metabolites VNT were performed by incubation with rat liver microsomes (RLMs). Extraction vandetanib its from mixtures done protein precipitation. metabolism was giving one oral dose (30.8 mg/kg) to Sprague Dawley rats metabolic cages using gavage. Urine gathered...
A hybrid library of compounds based on indazole-based thiadiazole containing thiazolidinone moieties (1-17) was synthesized. The synthesized were screened in vitro for their inhibition profile against targetedacetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities. All the derivatives demonstrated a varied range inhibitory activities having IC50 values ranging from 0.86 ± 0.33 μM to 26.73 0.84 0.89 0.12 27.08 0.19 (BuChE), respectively. results obtained compared with...
Nonfullerene acceptors (NFAs) have emerged as tremendous materials, efficiently advancing bulk-heterojunction organic solar cells (OSCs) technology. Unlike their fullerene counterparts, NFAs offer the unique advantage of finely tunable electronic energy levels and optical characteristics, which correspond to substantial enhancement in power conversion efficiency OSCs. Herein, we introduced a new series near-infrared (AY1–AY8) advance this technology further. Our research deeply investigates...
The potential applications of nonfullerene acceptors (NFAs) such as tunable band gaps, improved charge separation, wide-range absorption, enhanced power conversion efficiency, and operational stability make them highly favorable for organic photovoltaic applications. Herein, we designed eight novel structurally modified nonfused benzoselenadiazole (BSe)-based A2-D-A1-D-A2-type NFAs efficient solar cells (OSCs). These newly modeled BSe-based NFA series contain BSe the central core. We...
Efficient and stable hole-transport material (HTM) is essential for enhancing the efficiency stability of high-efficiency perovskite solar cells (PSCs). The commonly used HTMs such as spiro-OMeTAD need dopants to produce high efficiency, but those degrade film cause instability. Therefore, development dopant-free N,N'-bicarbazole-based HTM receiving huge attention preparing stable, cost-effective, efficient PSCs. Herein, we designed proposed seven distinct small-molecule-based (B1-B7), which...