A5061560498- Protein Interaction Studies and Fluorescence Analysis
- Drug Transport and Resistance Mechanisms
- Chronic Lymphocytic Leukemia Research
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
- Chronic Myeloid Leukemia Treatments
- Monoclonal and Polyclonal Antibodies Research
- Analytical Methods in Pharmaceuticals
- Cancer therapeutics and mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Alzheimer's disease research and treatments
- Analytical Chemistry and Chromatography
- Computational Drug Discovery Methods
- Colorectal Cancer Treatments and Studies
- Synthesis and biological activity
- Pharmacogenetics and Drug Metabolism
- Quinazolinone synthesis and applications
- Glycosylation and Glycoproteins Research
- Surfactants and Colloidal Systems
- Protein purification and stability
- Proteins in Food Systems
- Pneumonia and Respiratory Infections
- Cholinesterase and Neurodegenerative Diseases
- Advanced Breast Cancer Therapies
- Polysaccharides Composition and Applications
King Saud University
2016-2025
Al-Azhar University
2024
Cairo Higher Institute
2021
Riyadh Elm University
2018-2019
Aligarh Muslim University
2016
University of Nottingham
2009-2016
Purpose This study aimed to investigate the effects of ejaculatory abstinence on sperm parameters. Methods analysis was registered in PROSPERO (CRD42023472124). We performed a search PubMed using following text terms: ((“sperm parameters” OR “sperm analysis” [Mesh]) AND (“sperm DNA fragmentation” “DNA (“sexual abstinence” [Mesh] “abstinence”)) and an advanced Scopus terms fragmentation”) (“abstinence”). The parameters that were investigated volume, total motility, progressive concentration,...
Exogenous drugs that are used as antidote against chemotheray, inflammation or viral infection, gets absorbed and interacts reversibly to the major serum transport protein i.e. albumins, upon entering circulatory system. To have a structural guideline in rational drug designing synthesis of with greater efficacy, binding mechanism an antineoplastic anti-inflammatory Nordihydroguaiaretic acid (NDGA) human bovine albumins (HSA & BSA) were examined by spectroscopic computational methods. NDGA...
In this report, we have investigated the binding affinity of tofacitinib with human serum albumin (HSA) under simulated physiological conditions by using UV–visible spectroscopy, fluorescence quenching measurements, dynamic light scattering (DLS), differential scanning calorimetry (DSC) and molecular docking methods. The obtained results demonstrate that intensity HSA gets quenched occurs in static manner. Binding parameters calculated from modified Stern–Volmer equation shows drug binds to...
In continuation of our endeavor with respect to the development potent and effective isatin-based anticancer agents, we adopted molecular hybridization approach design synthesize four different sets isatin-quinazoline (6a-f 7a-e)/phthalazine (8a-f)/quinoxaline (9a-f) hybrids. The antiproliferative activity target hybrids was assessed towards HT-29 (colon), ZR-75 (breast) A-549 (lung) human cancer cell lines. Hybrids 8b-d emerged as most active congener in this study. Compound 8c induced...
Background: Talazoparib (BMN673) is a new poly(ADP-ribose) polymerase inhibitor that has been FDA approved for patients suffering from metastatic breast cancer with germline BRCA mutations. Method and Results: In the current study, an accurate efficient liquid chromatography-tandem mass spectrometry (LC–MS/MS) analytical methodology was developed TZB estimation in addition to its metabolic stability assessment. lapatinib (LAP) (which chosen as internal standard; IS) were separated using...
Gilteritinib (Xospata®) is a tyrosine kinase inhibitor (TKI) that works by inhibiting numerous receptor kinases, involving AXL and FMS-like 3 (FLT3). (GTB) was approved (28 November 2018) the USFDA for treatment of refractory or relapsed (R/R) acute myeloid leukemia (AML) with FLT3 mutation. In current study, fast, highly sensitive, specific ultra-performance liquid chromatography tandem mass spectrometry (UPLC–MS/MS) analytical methodology created GTB determination in human liver microsomes...
Palbociclib (Ibrance; Pfizer) was approved for the management of metastatic breast cancer characterized by hormone receptor‐positive/human epidermal growth factor receptor 2 negative status. The objective this study to create a fast, precise, environmentally friendly, and highly sensitive ultra‐high‐performance liquid chromatography‐tandem mass spectrometry approach quantifying palbociclib (PAB) in human liver microsomes with application assessing metabolic stability. validation features...
Traumatic brain injury (TBI) is described as a structural damage or physiological disturbance of function that occurs after trauma and causes disability death in people all ages. New treatment targets for TBI are being explored because current medicines frequently ineffectual poorly tolerated. There increasing evidence following TBI, there widespread changes autophagy-related proteins both experimental clinical settings. The study investigated if Boswellia Sacra Gum Resin (BSR) (500 mg/kg)...
Abstract Osimertinib (Tagrisso, AstraZeneca Pharmaceuticals) is the inaugural third-generation irreversible EGFR-TKI that specifically targets both EGFR T790M resistant mutation and EGFR-TKI-sensitizing mutations. On September 25, 2024, Food Drug Administration authorized osimertinib (OSM) for adult patients with locally advanced, unresectable (stage III) non-small cell lung cancer (NSCLC). The target of this work was to establish a fast, accurate, environmentally friendly, highly sensitive...
Background Several epidemiological studies and intervention trials have demonstrated that grapes blueberries, which are rich in flavanols, can lower the risk of cardiovascular disease. However, mechanisms action these compounds remain unclear due to their low bioavailability.
Background Adrenomedullin (AM) is a potent angiogenic, antioxidant and anti-inflammatory peptide protecting the developing lung from injury due to bronchopulmonary dysplasia (BPD) of preterm infant. At this stage, no data on potential effects chorioamnionitis (CA) occurrence glucocorticoids (GC) administration AM in lungs are still lacking.
Purpose Ejaculatory abstinence (EA) duration is recognized to impact semen parameters. This study aims evaluate the effects of varying EA durations on quality parameters, distinguishing between normospermic and sub-fertile men, provide insights into tailored recommendations for improved fertility outcomes. Methods We retrospectively analyzed 23,527 samples from men undergoing infertility evaluation 2013 2024. Semen including sperm concentration, motility, morphology, were assessed...
Abstract ASP3026 is a recently formulated and highly selective inhibitor designed to target the ALK kinase. efficiently inhibited kinase activity demonstrated superior selectivity at panel of Tyr-kinases compared crizotinib. The this investigation was establish accurate, fast, green, sensitive Ultra-high performance liquid chromatography- Tandem mass spectrometry (UHPLC-MS/MS) technique for assessing concentration in human liver microsomes (HLMs). In vitro incubation, metabolic stability...
Metabolic stability studies demonstrated moderate baricitinib extraction ratio. Minor adjustments to the pyrrole (88%) and pyrimidine (5%), during drug design, may increase novel derivatives' safety metabolic compared baricitinib.
Abstract The first targeted Rho-associated protein kinase 2 inhibitor was Belumosudil (Rezurock). After at least two systemic treatments failed for chronic graft-versus-host disease in adults and children aged 12 older, belumosudil (BLS) approved on July 16, 2021. This study established a validated Ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) system to estimate BLS HLMs assess metabolic stability. Agilent C18 column used separate encorafenib (internal...