Giuseppe Lapergola

ORCID: 0000-0003-1989-617X
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Research Areas
  • Neonatal Respiratory Health Research
  • Autoimmune and Inflammatory Disorders Research
  • Neonatal and fetal brain pathology
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Cardiac Arrest and Resuscitation
  • Streptococcal Infections and Treatments
  • S100 Proteins and Annexins
  • Infant Development and Preterm Care
  • Neuroscience of respiration and sleep
  • Pediatric Pain Management Techniques
  • Cardiac, Anesthesia and Surgical Outcomes
  • Congenital Diaphragmatic Hernia Studies
  • Nail Diseases and Treatments
  • Acute Lymphoblastic Leukemia research
  • Rheumatoid Arthritis Research and Therapies
  • Parasitic Infections and Diagnostics
  • Cerebral Venous Sinus Thrombosis
  • Retinal and Optic Conditions
  • Parasitic Diseases Research and Treatment
  • Inflammasome and immune disorders
  • Parasites and Host Interactions
  • Anesthesia and Neurotoxicity Research
  • Ocular Diseases and Behçet’s Syndrome
  • Pregnancy and Medication Impact
  • Pediatric health and respiratory diseases

University of Chieti-Pescara
2016-2025

Medical University of Lodz
2019

IRCCS Materno Infantile Burlo Garofolo
2019

Hubei University of Technology
2019

Background Adrenomedullin (AM) is a potent angiogenic, antioxidant and anti-inflammatory peptide protecting the developing lung from injury due to bronchopulmonary dysplasia (BPD) of preterm infant. At this stage, no data on potential effects chorioamnionitis (CA) occurrence glucocorticoids (GC) administration AM in lungs are still lacking.

10.1080/14767058.2025.2456502 article EN cc-by The Journal of Maternal-Fetal & Neonatal Medicine 2025-01-23

Abstract Background To validate the role of Activin A in early diagnosis and prognosis preterm newborns at risk for intraventricular hemorrhage neurological sequelae by means cerebral ultrasound magnetic resonance imaging (MRI), currently considered standard care procedures. Methods We conducted an observational case–control study 46 newborns, 23 with (IVH group) controls matched gestational age. Standard clinical, laboratory, monitoring procedures urine measurement were performed four...

10.1186/s13052-025-01938-4 article EN cc-by ˜The œItalian Journal of Pediatrics/Italian journal of pediatrics 2025-03-20

Autoimmune sensorineural hearing loss, also known as autoimmune inner ear disease (AIED) is a rare clinical entity characterized by progressive and bilateral loss often accompanied vestibular symptoms. Diagnosis essential consistent number of patients show positive response to steroids alone or in association with other immunosuppressive drugs. AIED defined primary when the limited ear, whereas up third cases it associated systemic diseases such Behçet (BD). BD multisystem vasculitis...

10.1186/s13052-016-0291-2 article EN cc-by ˜The œItalian Journal of Pediatrics/Italian journal of pediatrics 2016-09-06

Delivery room (DR) management may play an important role in the development and prevention of lung injury. Therefore, a cohort low birth weight infants (LBW), we investigated effects two different recruitment maneuvers, such as positive pressure ventilation (PPV) sustained inflation (SI) on adrenomedullin (AM), well-established lung-specific vasoactive agent.This is prospective case-control randomized study 44 LBW spontaneously breathing with respiratory failure at requiring support. were to...

10.1055/s-0039-1692133 article EN American Journal of Perinatology 2019-06-25

Pediatric open-heart surgery with cardiopulmonary bypass (CPB) still remains a risky interventional procedure at high mortality/morbidity. To date, there are no clinical, laboratory, and/or monitoring parameters providing useful information on perioperative stress. We therefore investigated whether blood concentrations of glutathione (GSH), powerful endogenous antioxidant, changed in the period.We conducted an observational study 35 congenital heart disease (CHD) children whom standard...

10.3390/diagnostics9030118 article EN cc-by Diagnostics 2019-09-13

Serum calprotectin (MRP8/14) is currently being studied as a promising biomarker of disease activity and outcome in patients with juvenile idiopathic arthritis (JIA) but the data literature are conflicting. The aim our study was to investigate potential role serum flare/remission group nsJIA during follow-up period 18 months. In this prospective longitudinal study, two groups ns-JIA (55 active 56 remission according Wallace's criteria) control (50 children) were recruited at baseline from...

10.3390/ijms24021671 article EN International Journal of Molecular Sciences 2023-01-14

Abstract Objectives The early detection of preterm infants (PI) at risk for intraventricular hemorrhage (IVH) and neurological sequelae still constitutes an unsolved issue. We aimed validating the role S100B protein in diagnosis prognosis IVH PI by means cerebral ultrasound (CUS) magnetic resonance imaging (MRI) today considered standard care procedures. Methods conducted observational case-control study 216 whom 36 with 180 controls. Standard clinical, laboratory, radiological monitoring...

10.1515/cclm-2021-0278 article EN Clinical Chemistry and Laboratory Medicine (CCLM) 2021-05-19

Abstract Objectives Seizures (SZ) are one of the main complications occurring in infants undergoing therapeutic hypothermia (TH) due to perinatal asphyxia (PA) and hypoxic ischemic encephalopathy (HIE). Phenobarbital (PB) is first-line strategy, although data on its potential side-effects need elucidation. We investigated whether: i) PB administration PA-HIE TH-treated affects S100B urine levels, ii) could be a reliable early predictor SZ. Methods performed prospective case-control study 88...

10.1515/cclm-2023-1471 article EN Clinical Chemistry and Laboratory Medicine (CCLM) 2024-01-30
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